Enteroviral infections: modern clinical, epidemiological features

Authors

  • E. V. Usacheva Zaporizhzhia State Medical University,
  • E. V. Ryabokon Zaporizhzhia State Medical University,
  • A. M. Kamyshny Zaporizhzhia State Medical University,
  • D. A. Zadiraka Zaporizhzhia State Medical University,
  • T. M. Pakholchuk Zaporizhzhia State Medical University,
  • О. М. Firulina Regional Infectious Clinical Hospital,

DOI:

https://doi.org/10.14739/2310-1210.2017.2.95681

Keywords:

enteroviral infection, epidemiology, adults, children

Abstract

It has been a clear increase in the number of enteroviral infection (EI) activation in recent years. EI are the widespread agents of infectious diseases in children and adults. Moreover this virus affects various organs and tissues and it results in different symptoms of EI in patients of different age groups. All these facts lead to the difficulties in diagnostics, treatment and prophylactics of the EI clinical forms.

Aim of the study was to improve diagnostics of the enteroviral infections (EVI) in children and adults based on the epidemiological features of the definitive clinical forms in season 2016.

Materials and Methods. The study was carried out as a part of the Grant Agreement between Zaporizhzhia State Medical University (ZSMU) and "Regional Training Centre of Research in the HealthCare System" (theRepublic ofKazakhstan). 185 patient’s medical documentation was analyzed in the inpatient department. Only symptomatic patients with clinical manifestation of enteroviral infection different forms were included into the study. Polymerase chain reaction (PCR) was used for enteroviruses detection.

Results and Discussion: Enterovirus was identified in biological liquids in 36.7 % (68 patients) of cases. Patients with meningitis (35) prevailed among them. Other 9 patients had: exanthema, gastroenteritis, herpangina. An increase in the incidence of morbidity has been noted in August - November with the prevalence of meningitis in August – September, herpangina – in November. Most frequently EVI was detected in children aged 7 – 12 years and in young children. Meningitis dominated in school-aged children, exanthema – in children up to 3 years old.

Conclusions. EVI is widespread cause of meningitis, vesicular or ulcerative lesions of the posterior oropharyngeal structures and exanthemas in young and early school-age children. Clear association between season and age features with type of the EVI clinical manifestation has been noted. 

References

Nair, H., Brooks, W. A., Katz, M., Roca, A., Berkley, J. A., Madhi, S. A., et al. (2011) Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis. Lancet, 378(9807), 1917–1930. doi: 10.1016/S0140-6736(11)61051-9.

Marova, A. A., Oksanich, A. S., Kaira, A. N., Meskina, E. R., Medvedeva, E. A., Ivanova, O. E., et al. (2012) Primenenie metoda multipleksnoj PCR-RV dlya differencial’noj diagnostiki kishechnykh virusnykh infekcij [Experience of application of multiplex QPCR for intestine viral infection differential diagnostics]. Zhurnal mikrobiologii, e´pidemiologii i immunobiologii, 6, 39–45. [in Russian].

Xu, W., Liu, C.-F., Yan, L., Li, J.-J., Wang, L.-J., Qi, Y., et al. (2012) Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system. Virol J., 9, 8. doi: 10.1186/1743-422X-9-8.

Seiff, A. (2012) Cambodia unravels cause of mystery illness. Lancet, 380(9838), 206. doi: 10.1016/S0140-6736(12)61200-8.

Böttcher, S., Neubauer, K., Baillot, A., Rieder, G., Adam, M., & Diedrich, S. (2015) Stool screening of Syrian refugees and asylum seekers in Germany, 2013/2014: Identification of Sabin like polioviruses. Int J Med Microbiol., 305(7), 601–6. doi: 10.1016/j.ijmm.2015.08.008.

Park, N., Schweers, N. J., & Gustin, K. E. (2015) Selective Removal Of FG-Repeat Domains From The Nuclear Pore Complex By Enterovirus 2Apro. J Virol., 89(21), 11069–79. doi: 10.1128/JVI.00956-15.

Gu, H., Liu, Z., Zhang, L., Chen, Y., Yang, S., Zhang, W., & Li, X. (2015) The etiological and clinical characteristics of hospitalized children with hand, foot and mouth disease in Beijing in 2013. Zhonghua Er Ke Za Zhi, 53(6), 459–63.

Song, Y., Cheng, X., Yang, X., Zhao, R., Wang, P., Han, Y., et al. (2015) Early growth response-1 facilitates enterovirus 71 replication by direct binding to the viral genome RNA. Int J Biochem Cell Biol., 62, 36–46. doi: 10.1016/j.biocel.2015.02.012.

Smura, T., Blomqvist, S., Vuorinen, T., Ivanova, O., Samoilovich, E., Al-Hello, H., et al. (2014) The Evolution of Vp1 Gene in Enterovirus C Species Sub-Group That Contains Types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99. PLoS One., 9(4), e94579. doi: 10.1371/journal.pone.0094579.

Khong, W. X., Yan, B., Yeo, H., Tan, E. L., Lee, J. J., Chow, V. T. et al. (2011) A non mouse-adapted Enterovirus 71 (EV71) strain exhibits neurotropism causing neurological manifestations in a novel mouse model of EV71 infection. J Virol. 86(4), 2121–2131. doi: 10.1128/JVI.06103-11.

Lukashev, A. N., Shumilina, E. Y., Belalov, I. S., Ivanova, O. E., Eremeeva, T. P., Reznik, V. I., et al. (2014) Recombination strategies and evolutionary dynamics of the Human enterovirus A global gene pool. J Gen Virol., 95(4), 868–873. doi: 10.1099/vir.0.060004-0.

Liao, C. C., Liou, A. T., Chang, Y. S., Wu, S. Y., Chang, C. S., Leee, C.-K., et al. (2014) Immunodeficient Mouse Models with Different Disease Profiles by in vivo Infection with the Same Clinical Isolate of Enterovirus 71. J Virol., 88(21), 12485–12499.

Lashkevich,V. A., Koroleva, G. F., Lukashev, A. N., Karmysheva, V. Ya., Mustafina, A. N., Khudyakova, L. V., & Shumilina, E. (2011) Enterovirus 71: HFMD-like disease, encephalomyelitis, acute pulmonary edema Epidemiology. Yu.Infect. Bol, 6, 38–47.

Downloads

How to Cite

1.
Usacheva EV, Ryabokon EV, Kamyshny AM, Zadiraka DA, Pakholchuk TM, Firulina ОМ. Enteroviral infections: modern clinical, epidemiological features. Zaporozhye Medical Journal [Internet]. 2017Mar.14 [cited 2024Dec.23];19(2). Available from: http://zmj.zsmu.edu.ua/article/view/95681

Issue

No. 2 (2017): Zaporozhye medical journal

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)