Zaporozhye Medical Journal

Studying the impact of probiotic agents on the pathogenetic and clinical features of generalized periodontitis

M. A. Luchynskyi — 2024-12-04

Generalized periodontitis remains one of the most prevalent dental diseases, complications of which significantly deteriorate patients’ quality of life. Currently, the use of probiotic agents is considered a promising direction to enhance the effectiveness of non-surgical treatment of this pathology. Studying the impact of different probiotics on the pathogenetic and clinical features of generalized periodontitis will allow proposing optimized protocols for comprehensive treatment, reducing patient rehabilitation periods and improving the overall dental health of the population.

The aim of this study is to examine the influence of various probiotic agents on the pathogenetic and clinical characteristics, treatment effectiveness of generalized periodontitis in adult patients by analyzing professional scientific literature.

The literature review provides a brief overview of various probiotic groups and discusses pathogenetic mechanisms of their interaction with the microbiota of oral biofilms. The immunomodulatory mechanisms of probiotics on local and systemic immune responses in patients with generalized periodontitis, inhibition of enzymes responsible for bone tissue resorption, are presented. The analysis results of scientific sources regarding the dynamics of changes in clinical symptoms, microbiological, immunological, and biochemical parameters of saliva and blood serum in individuals with generalized periodontitis receiving comprehensive rehabilitation using probiotic agents compared to patients treated with traditional protocols are provided. The study highlights statistical differences in clinical and laboratory indicators of periodontitis progression at different treatment intervals.

Conclusions. The use of probiotic agents for treating patients with generalized periodontitis significantly influences the clinical course of the disease by altering the species composition of dental biofilms and modulating local immune and inflammatory reactions. However, the known results of experimental and clinical studies often have conflicting findings regarding the efficacy of specific probiotic strains and the duration of inflammatory process stabilization over extended periods after treatment, which means a further study is required.

Modern possibilities of minimally invasive biliary drainage techniques for patients with malignant jaundice

E. V. Didenko — 2024-12-04

Malignant biliary obstruction is a complex condition requiring a multimodal approach for both diagnosis and treatment. Most patients diagnosed with this disease are not candidates for radical surgery, as they come to us at advanced stages of the disease. Therefore, they need quality palliative care.

Aim. Based on the data from scientific articles and literature, to highlight the possibilities of minimally invasive biliary drainage techniques in patients with malignant jaundice.

The article analyzes the available sources of scientific literature and articles from the electronic resources PubMed, Google Scholar, UpToDate from 2019 to 2024. Minimally invasive methods of biliary drainage have demonstrated significant advantages over open surgeries, including a reduced risk of surgical complications, shorter rehabilitation period, and the ability to perform the procedure under local anesthesia. However, despite technological progress and accumulated clinical experience, a number of unresolved issues remain, in particular, related to choosing the optimal drainage method for a particular patient, and assessing the effectiveness and safety of a specific technique.

Conclusions. The most controversial issue is the choice between endoscopic and percutaneous drainage methods. Some studies have shown that endoscopic drainage might be more effective in patients with tumors located in the distal bile ducts, while percutaneous drainage might be more appropriate in case of proximal obstructions. Therefore, the situation calls for additional studies to evaluate long-term results of different drainage techniques and the effectiveness of plastic, covered and uncovered metal stents in different clinical situations.

What is known about Peutz–Jeghers syndrome (a literature review)

M. H. Melnychenko — 2024-12-04

Peutz–Jeghers syndrome (PJS) is an autosomal dominant disease, which in most cases is caused by mutation of the tumor suppressor gene STK11 and is characterized by the development of hamartomatous polyps in the digestive tract and the presence of hyperpigmented spots on the skin and mucous membranes. Late diagnosis of PJS leads to acute intestinal obstruction or bleeding.

The aim of the study is to summarize the data and current views on the early diagnosis and treatment of PJS in children and processing information on monitoring of PJS complications.

To achieve this goal, we have analyzed the sources of professional literature indexed in scientometric databases for the period 2014–2024. The analysis of the professional literature has shown that the triad is characteristic for PJS diagnosis: pigmented spots on the skin and oral mucosa, digestive tract polyposis, and heredity. The timing of symptom onset is an important aspect that requires further study of the clinical course and prognosis of the disease.

Conclusions. Phenotypic suspicion involves the formation of risk groups using extraintestinal signs – pigmentation of the mucous membranes and lips – an early visual symptom that makes it possible to recognize PJS, prescribing timely examination and treatment long before the onset of complications. Dynamic observation and prevention of complications in risk groups – both in the presence of a family history and in newly diagnosed children with polyps and specific pigmentation should be provided. The main method of PJS diagnosis is endoscopic, and the main treatment is surgical.

Vulvovaginal atrophy: modern approaches to diagnostics and management

V. H. Siusiuka — 2024-12-04

The aim of the review is to analyze the latest data on the current state of diagnosis and management of a common benign vulvar and vaginal disease in postmenopausal women – atrophic vulvovaginitis.

The paper presents an analysis of national and foreign scientific publications on the diagnosis and management of vulvovaginal atrophy and also focuses on the modern nomenclature and terminology of this pathology. Vulvovaginal atrophy is a common and progressive condition affecting on average more than 50 % of postmenopausal women, and its development and severity depend mainly on the duration of hypoestrogenism. Such a hormonal imbalance with a gradually increasing estrogen deficiency leads to atrophic changes in the tissues of the female genital organs and thinning of the vaginal epithelium. Degenerative alterations are accompanied by inflammatory phenomena and disturbances in the vaginal microflora. Atrophic lesions in the genitourinary system induce urinary incontinence aggravation, dysuria, increased micturition frequency, and recurrent urinary tract infections.

Vulvovaginal atrophy is diagnosed based on appropriate clinical assessments as well as with the involvement of validated questionnaires. Differential diagnosis of the vulvovaginal atrophy should include all pathological conditions imitating the clinical symptoms and signs.

Experts of the International Society for the Study of Women’s Sexual Health and the North American Society of Menopause have proposed a new nomenclature, namely, the terms “vulvovaginal atrophy” and “atrophic vaginitis” have been supplanted by “genitourinary menopausal syndrome”.

First-line therapy for mild symptoms is non-hormonal vulvar and vaginal lubricants, vaginal moisturizers used on a regular basis. Hormonal therapy (both transdermal and oral) remains the most effective choice for the treatment of clinical manifestations, but contraindications to its use should be considered. In women with contraindications to systemic hormonal therapy, it is possible to prescribe estrogens in the form of vaginal suppositories or vaginal cream. 5-Aminolevulinic acid photodynamic therapy can be one of the promising methods in the treatment of this women’s clinical group.

Given the serious consequences of vulvovaginal atrophy for the patients’ health and quality of life, timely diagnosis of the disease in accordance with its specificity and possible complications is of primary importance for the successful treatment and management of this pathology.

Conclusions. Vulvovaginal atrophy has been shown to be a common disease, especially among women in the postmenopausal period, based on the analysis of national and foreign scientific publications. The pathogenesis of vulvovaginal atrophy is associated with hypoestrogeny which results in structural and functional abnormalities of the genital organs such as mucus thinning, loss of elasticity, changes in microbiota and increased pH. Given the new nomenclature and terminology, it is appropriate to use the term “genitourinary menopausal syndrome” (GMS or GUMS) in lieu of “vulvovaginal atrophy”.

The use of a vascularized fibular flap in the treatment and surgical rehabilitation of military trauma patients

P. O. Badiul — 2024-12-04

Aim. The purpose of the work is to demonstrate the possibilities of using a vascularized fibular flap to replace bone defects in the treatment of acute military trauma and its consequences at the rehabilitation stage.

Materials and methods. An anatomical feature description of the vascularized fibular flap with a cutaneous component. Clinical cases of the vascularized fibular flap use to reconstruct bone and soft tissue defects after military injuries. In the presented cases, vascularized fibula osteocutaneous flaps were used.

Results. Two clinical cases of reconstruction using the fibula flap are presented. The first case presents a patient with a total mandibular defect resulting from a gunshot wound. The second case presents a patient with consequences of a mine-shrapnel injury of the left forearm and an ulnar defect of about 12 cm in length and the resultant inability to perform rotational movements. Vascularized fibula osteocutaneous flaps were used for reconstruction in both cases being transferred to the recipient site, and microvascular anastomoses were performed for flap reperfusion.

Conclusions. Adding a free fibula flap to the reconstructive surgeon’s arsenal enables one-stage reconstructions of large wounds with bone defects after injuries or oncological resections without significant musculoskeletal functional loss to donor limbs.

100 years – life goes on (a clinical case)

V. I. Kryvenko — 2024-12-04

The aim of this work is to draw attention to the peculiarities of long-lived patient functioning and to assess the state of health in a 100-year-old patient, her cognitive functions and life factors contributing to active longevity.

Materials and methods. We have described and analyzed a case of the 100-year-old female patient’s health, the influence of factors for active aging prolongation (nutrition, physical activity, labor, psychological state, hobbies) on a specific example, conducted a review of the scientific literature regarding the reasons for longevity and people’s lifestyles.

Results. According to projections for demographic prospects, by 2050, the number of elderly people in the world will increase to 16 %, and every sixth person will be older than 65 years. Thus, in the EU countries, the expected life expectancy for men is 74–77 years, women ‒ 80–82 years. Based on forecasts, the number of people aged 80 and over will triple: from 143 million in 2019 to 426 million in 2050. Therefore, the relevance of maintaining active longevity is beyond doubt. Examples of long-lived people on the planet have been analyzed and given. The presented clinical case is the 100-year-old woman who underwent a full clinical examination. Her physical and mental state as well as cognitive functions have been evaluated. The life and occupational trajectories, her hobby (singing), social activity, eating habits have been analyzed. Biological age has also been assessed. The biological age of our patient has been determined by metabolic laboratory parameters: complete blood count, creatinine, bilirubin, lipid levels, blood glucose, urea, AST, ALT, albumin, electrolytes.

Conclusions. According to the conducted study, the biological age of the patient is 93 years, that is 7 years younger than the chronologic age. Our patient is not overweight, has daily walks lasting up to 1-2 hours, lives alone, but enjoys communicating with friendly people, has been adhering to a balanced diet over the past 40 years. The following are of great importance to the patient: a normal mental state, work after retirement, especially creative work, a positive attitude to life, communication with positive people, music and singing. Thus, a person can live up to 100 years without significant health problems.

Study on the prevalence of traditional smoking and the use of modern electronic nicotine delivery systems in different age groups of patients with ischemic heart disease

O. O. Zhurba — 2024-12-04

The aim to define the frequency of traditional smoking and electronic cigarette use among coronary heart disease (CHD) patients of different age groups.

Materials and methods. The study included patients with CHD who underwent off-pump coronary artery bypass surgery (n = 3674). The mean age of the study participants was 60.6 ± 0.8 years. The material for analysis was anamnestic data regarding traditional smoking or the use of electronic nicotine delivery devices and a smoking history. The study design was based on the patient’s age group according to the WHO age classification.

Results. The article raises an actual problem of defining the impact of electronic cigarettes and traditional smoking on health risk for CHD patients and the frequency of smoking types taking into account the patients’ age. Nicotine addiction has been revealed in 67.3 % of patients among the study participants that was significantly higher than the proportion of never-smokers, p = 0.0001, χ²= 56.29. It has been found that 93.0 % of patients preferred traditional cigarette smoking to electronic cigarettes, p = 0.0001, χ²= 2101.45, and the frequency of traditional smoking was significantly lower among young patients (21.3 %) as compared to older age groups of patients: middle-aged – 38.5 % (р = 0.0001, χ²= 62.40), elderly – 44.0 % (р = 0.0001, χ²= 116.53) and old-aged – 42.1 % (р = 0.0001, χ²= 95.67). Smoking cessation frequency has been shown to be significantly higher in the older groups: middle-aged (p = 0.0001, χ²= 17.42), elderly (p = 0.0001, χ²= 15.59) and old-aged (p = 0.003, χ²= 9.05) compared to that among CHD patients of a younger age. The determined frequency of using only electronic cigarettes as a smoking experience or transition from tradition smoking has been demonstrated to be significantly higher exclusively among young people compared to other age groups: middle-aged patients (p = 0.0001, χ²= 170.24), elderly (p = 0.0001, χ²= 288.63) and old-aged (p = 0.0001, χ²= 290.01).

Conclusions. Tobacco smoking as one of the leading risk factors has been established to be an extremely common phenomenon in the sample of CHD patients with the frequency of 67.3 %, that was significantly higher than the number of never-smokers, p = 0.0001, χ²= 56.29. The rates demonstrating the prevalence of traditional and electronic cigarette smoking based on the age of patients with coronary heart disease have been determined. The incidence of smoking status types (quit smoking, switch to electronic cigarettes, dual users) according to the age aspect has been revealed.

The endothelial NO synthase content in the blood serum of patients with coronavirus disease (COVID-19) with pneumonia in association with hemostatic parameters depending on the clinical course and its prognostic significance

O. V. Riabokon — 2024-12-04

Aim: to investigate the content of eNOS in the blood serum of patients with coronavirus disease (COVID-19) with pneumonia in association with hemostatic parameters and to determine its prognostic value in assessing the risk of oxygen dependence and death.

Material and methods. There were 123 patients with COVID-19 with pneumonia under observation. All patients were examined and treated in accordance with the Order of the Ministry of Health of Ukraine No. 722 dated 28.03.2020. The eNOS content in the patients’ serum was determined by enzyme-linked immunosorbent assay.

Results. It was found that the content of eNOS in the blood serum of patients with COVID-19 with pneumonia at the time of hospitalization was 9.0 [7.0; 12.0] days lower (p < 0.001) than in healthy subjects. The development of oxygen dependence in patients with COVID-19 with pneumonia was accompanied by worsening of endothelial dysfunction and procoagulant changes, which was confirmed by a decrease in the content of eNOS in the blood serum (p < 0.001), an increase in the level of fibrinogen (p < 0.05) and D-dimer (p < 0.05). The threshold level of eNOS in the blood serum ≤327.09 pg/ml (AUC = 0.861, p < 0.001) was predictive of the onset of oxygen dependence. In patients with COVID-19 with pneumonia who subsequently died, at the time of hospitalization, eNOS levels were lower (p < 0.001) than in patients who recovered, which was combined with a higher level of D-dimer (p < 0.05) and its more frequent increase (p = 0.04) compared with patients who recovered. The eNOS content in the blood serum of patients with COVID-19 with pneumonia was correlated (p < 0.05) not only with the lethal outcome of the disease, but also with the formation of thrombotic complications, which occurred more often in patients with COVID-19 with pneumonia in the event of an adverse outcome (p = 0.0001). The threshold level of eNOS in the blood serum ≤201.75 pg/ml (AUC = 0.892, p < 0.001) was indicative of a high probability of death.

Conclusion. The eNOS content in the blood serum of patients with COVID-19 pneumonia at the time of hospitalization is lower (p < 0.001) than in healthy individuals, and the degree of its decrease depends on the severity of the disease, the development of oxygen dependence and the subsequent outcome of this disease. Limiting levels of eNOS in the blood serum of patients with COVID-19 pneumonia, which are important for predicting the risk of developing oxygen dependence and fatal outcome of the disease, have been established.

Dynamics of soft tissue thickness in the area of one-stage dental implantation with the use of a soft tissue cuff reinforced with bone graft material

Ye. Yu. Niezhentsev — 2024-12-04

Aim. The study aims to compare the dynamics of the increase in the thickness of soft tissues in the area of one-stage dental implantation after the use of a xenogenic collagen matrix and a soft tissue cuff reinforced with bone graft material (BGM).

Materials and methods. The study enrolled 51 patients who received one-stage dental implantation. Depending on the dental implantation technique, the patients were divided into two groups. The main group comprised 25 patients who after teeth extraction had their implants placed into a prepared socket preliminary filled with Sensobone xenograft, after which BGM was formed with the subsequent fixation of a temporary crown. The comparison group included 26 patients who after teeth extraction had their implants placed into a prepared socket preliminary filled with Sensobone xenograft, after which the soft tissue area was filled with Senobone xenograft, with the subsequent fixation of the temporary crown. The attached mucous membrane (AMM) thickness around the implant was measured before implantation and again after 3 months and one year (the distance from the top of the alveolar ridge center to the middle of the muco-gingival junction in the vestibular direction was measured with a periodontal probe). The results of the study were processed on a PC using the statistical package of the licensed software Statistica 13.0 (Copyright 1984–2018 TIBCO Software Inc. All rights reserved. License No. JPZ804I382130ARCN10-J).

Results. The thickness of the AMM around the one-stage dental implantation area before implantation and in the dynamics did not depend on the jaw in both groups. Before implantation, the lowest values of the AMM thickness in patients of both groups were registered in the area of the canine and the first molar. The AMM thickness did not depend on the age and sex of the patients, as well as on the type of teeth and jaws. The use of BGM in one-stage dental implantation provided a significant increase in the AMM thickness by 1.38 mm in 3 months after implantation, and by 1.45 mm in a year (the intergroup difference was 0.29 mm in 3 months and 0.32 mm in a year), and a significant increase in the AMM thickness on both jaws, by 1.36 mm on the upper jaw and 1.41 mm on the lower jaw in 3 months and by 1.44 mm on the upper jaw and by 1.5 mm on the lower jaw in a year (the intergroup difference was 0.32 mm on the upper jaw and 0.33 mm on the lower jaw in a year) as well as a significant increase in the AMM thickness in all teeth after a year of follow-up. There were no dental implant failures in both groups, and the survival rate of implants was 100 % one year after the placement.

Conclusions. The effectiveness of one-stage dental implantation is facilitated by the adequate AMM thickness provided by BGM.

Analysis of long-term outcomes after surgical treatment of patients with complicated forms of colon cancer

M. A. Kubrak — 2024-12-04

The aim of the study. To evaluate long-term outcomes in patients who underwent surgery due to complications of colon cancer in a general surgical hospital.

Materials and methods. The study group included 71 (100 %) patients with complicated forms of colon cancer. Radical surgical interventions were performed in 48 (67.6 %) patients, palliative cytoreductive operations – in 18 (25.4 %) hospitalized patients, symptomatic – in 5 (7.0 %) patients.

Results. In the postoperative period, only 37 (58.7 %) patients sought help from an oncologist at the third level of medical care. The remaining 26 (41.3 %) patients refused to consult an oncologist and specific treatments for whatever reason.

Conclusions. Of the 37 (58.7 %) operated patients who sought oncological care, a chemotherapy course was initiated for 19 (51.4 %), dynamic follow-up without specific treatments was recommended for 7 (18.9 %) patients and symptomatic treatments according to the standards of palliative medical care – for 9 (24.3 %). During the follow-up period, among 43 (68.3 %) patients with non-metastatic cancer, 6 (14.0 %) of the operated patients had local recurrences, 8 (18.6 %) – regional, and 12 (27.9 %) – distant ones. In 17 (39.5 %) patients, no findings on recurrent colon cancer were revealed. Cumulative 1-year and 3-year survival rates in this category of patients were 56.3 ± 5.9 % and 38.0 ± 5.8 %, respectively.

The effect of anxiety levels in women with hypertensive disorders on the pregnancy course and outcome

A. Ye. Husieva — 2024-12-04

Aim. To analyze the influence of anxiety levels in women with hypertensive disorders on the pregnancy course and outcome in order to identify the relationship between the psycho-emotional state of pregnant women and the probability of developing complications or adverse consequences.

Materials and methods. 120 pregnant women were examined and divided into three groups: group 1 – pregnant women with chronic arterial hypertension (CAH), n = 40; group 2 – pregnant women who developed gestational hypertension, n = 40; group 3 – pregnant women without hypertensive disorders, n = 40. The women underwent specialized psychometric testing to assess anxiety/stress levels. The analysis was carried out using the Spielberger–Hanin Scale, the Psychological Stress Scale (PSM-25) and the Impact of Traumatic Event Rating Scale (IES-R). Statistical processing of the results and graphic design were performed using a Microsoft Excel 2016 spreadsheet and the comprehensive data analysis program Statistica 10 for Windows.

Results. An elevated level of state and trait anxiety according to the Spielberger–Hanin scale prevailed in pregnant women with CAH, which was an additional stress factor and required continuous monitoring even before the pregnancy onset. Evaluating the IES-R scale results, high levels of the intrusion subscale in all studied groups could be caused directly by pregnancy as a stressful factor. According to the avoidance subscale, we have seen similar results, so, pregnancy contributed to overstraining psychological defense mechanisms. However, the predominance in the group of women with gestational hypertension have suggested that high blood pressure after 20 weeks of pregnancy was one of the contributory factors in the activation of mechanisms for avoiding anxiety. The results of the hyperarousal subscale have demonstrated that the presence of hypertensive disorders (before or during pregnancy) caused the autonomic nervous system activation with the body hyperreactivity. The absence of a high level of stress according to the PSM-25 in all studied groups has demonstrated that women did not experience mental discomfort, which required the use of a wide range of methods to reduce it. Cesarean section was the prevailing delivery mode, the highest percentage was among women with CAH. This group also had the highest number of premature births and the maximum proportion of complications in newborns, indicating the influence of CAH as a negative factor in pregnancy outcomes.

Conclusions. The results of this study have demonstrated that an increased level of anxiety in pregnant women could negatively affect their health, as well as the fetal development. In addition, concomitant hypertensive disorders in pregnancy could significantly complicate the pregnancy course, increasing the risk for premature birth and complications in newborns. Therefore, in today’s realities, it is extremely necessary to assess the psycho-emotional state of women in advance, involve specialist physicians, develop and implement a set of psycho-prophylactic measures to increase the neuropsychological stability of pregnant women and reduce the number of negative perinatal outcomes.

Emotional burnout among medical stuff of a neurosurgery center: analysis of prevalence, structure and risk factors

A. V. Rehush — 2024-12-04

Aim. To determine the prevalence and risk factors of emotional burnout among medical workers of a neurosurgery center.

Materials and methods. In 2022–2024, a prospective study of the medical staff involved in emergency care for patients with acute ischemic stroke, in particular mechanical thrombectomy, was conducted at the Center for X-ray Endovascular Neurosurgery of Kyiv City Clinical Hospital No. 1. The mean age of the sample was 32.2 ± 5.8 years. The sex structure was: 40 (80.0 %) men and 10 (20.0 %) women. The clinical-psychopathological, psychodiagnostic and statistical methods were used. The psychodiagnostic method was implemented by using the Maslach Burnout Inventory (MBI, C. Maslach et al., 1997).

Results. It has been determined that such a criterion as the sex of neurosurgery center medical staff did not affect the severity of any component of emotional burnout (p > 0.05). Statistically significant differences in the prevalence of high rates of emotional burnout components have been found between groups of medical staff with different specializations. Namely, it has been revealed that working in the center as a neurosurgeon was significantly associated with high rates of such components as “Emotional exhaustion” (p = 0.04) and “Depersonalization” (p = 0.006). A direct correlation has also been established between the total work experience, length of service at the neurosurgery center and the number of working hours per month with the intensity of emotional burnout manifestations in the selected contingent of individuals.

Conclusions. The prevalence of emotional burnout among medical staff of the neurosurgery center has been established for various components of this phenomenon: “Emotional exhaustion” – 52.0 %, “Depersonalization” – 40.0 %, “Reduction of personal achievements” – 50.0 %, indicating a high level of stress and negatively affecting the mental health of the selected contingent. The risk for developing emotional burnout among the medical staff rises with increasing workload, length of service and work experience at the center. An absolute risk factor for emotional burnout is a neurosurgical practice. The development of psychotherapeutic measures aimed at overcoming the manifestations of emotional burnout in medical workers and increasing their resilience to stressful working conditions of the neurosurgery center is promising.

Monitoring the properties of 1,2,4-triazole derivatives for the development of original antimicrobial drugs

L. I. Kucherenko — 2024-12-04

Aim. A comprehensive study on the antimicrobial properties of new 1,2,4-triazole derivatives using the tools of in silico and in vitro studies.

Materials and methods. Computer search techniques were used to find a compound with a strong antibacterial activity; in silico molecular docking (receptors for class A (PDB id: 1n9b) and class A SHV-1 (PDB id: 2zd8) beta-lactamase) and in vitro studies on 16 types of microorganisms. Then, the in silico analyzed compounds were tested in vitro for antimicrobial activity. After preparing solutions of different concentrations, the culture growth was measured on a zonal scale for detecting sizes of microbial growth inhibition zones after 24 hours (Antibiotic Zone Scale-C, model RW297, India) and a TpsDig2 software (2016, F. James Rohlf). Statistical analysis of the study results was carried out using the Statistica 13 software (StatSoft Inc., USA).

Results. From the results of molecular docking, a strong binding affinity to class A enzymes has been found in compounds 2, 7, so they could be effective in the treatment of infection caused by K. pneumoniae. The ascending order of the predicted binding affinity through the calculated score for TEM and SHV enzymes was as follows: compound 4 < compound 3 < compound 1 < compound 7 < compound 2. According to our results, the studied chemical compounds 1–4, 7 inhibited the growth of many microbial species of the Enterobacteriaceae, Morganellaceae, Pseudomonadaceae, Enterococcaceae, Staphylococcaceae and Bacillaceae families.

Conclusions. For the first time, studies on the complex inhibitory effect of chemical compounds 1–4, 7 were conducted using 16 bacterial strains. Evident antibacterial effects of the studied compounds have been established: compound 1 against 13, compound 2 – 9, compound 3 – 10, compound 4 – 7, compound 7 – 10 out of 16 tested polyresistant bacterial strains.