Assessment of cardiac hemodynamics indicators in patients with arterial hypertension and non-alcoholic fatty liver disease depending on angiotensin II type 1 receptor A1166C gene polymorphism

Authors

  • O. Ya. Babak Kharkiv National Medical University, Ukraine,
  • M. M. Zaitseva Kharkiv National Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2018.3.130462

Keywords:

hemodynamics, hypertension, non-alcoholic fatty liver disease, genetic polymorphism, angiotensin II

Abstract

Aim of study is to estimate the indicators of cardiac hemodynamics in patients with arterial hypertension and non-alcoholic fatty liver disease depending on angiotensin II type 1 receptor (A1166C) gene polymorphism.

Materials and methods. 55 patients with arterial hypertension and non-alcoholic fatty liver disease were comprehensively examined. The study of angiotensin II type 1 receptor (A1166C) gene polymorphism was carried out by means of the polymerase chain reaction method. Accuracy of genotype frequency distribution was assessed in accordance with the Hardy-Weinberg Equilibrium (pi2 + 2 pipj + pj2 = 1).

Results. In the subgroup of patients with arterial hypertension and non-alcoholic fatty liver disease with the angiotensin II type 1 receptor gene (A1166C) C/C genotype the values of end-diastolic volume exceeded by 13.45 % and 28.31 %; the end-systolic volume –by 22.41 % and 39.09 %; the end-diastolic diameter – by 10.67 % and 38.95 %; the end systolic diameter – by 15.63 % and 29.11 %; the left ventricular mass – by 11.18 % and 19.38 %, whereas the ejection fraction was lower compared to patients with the A/C and A/A genotypes, respectively (p<0.05). According to our study results, no differences in left ventricular diastolic dysfunction were found depending on angiotensin II type 1 receptor (A1166C) gene polymorphism in the examined patients.

Conclusions. The C allele of angiotensin II type 1 receptor (A1166C) gene polymorphism in patients with arterial hypertension and non-alcoholic fatty liver disease is associated with the heart morphofunctional changes, namely, hypertrophy progression, left ventricular cavity size and volume enlargement and decrease in myocardial contractility.

 

 

 

References

  1. Kozlov, O. P. (2012). Stan vnutrishniosertsevoi hemodynamiky u khvorykh na nealkoholnu zhyrovu khvorobu pechinky [Condition of intracardiac hemodynamics in patients with non-alcoholic fatty liver disease]. Odeskyi medychnyi zhurnal, 4(132), 42–47. [in Ukrainian].
  2. Devi, N., Lakshmi, V., Padhy, K., Padhy, R., & Veerraju, P. (2013). Angiotensin converting enzyme gene polymorphism and hypertension in north coastal Andhra Pradesh, India. International J. of medical and health sciences, 2(1), 1–12.
  3. Wang, J. L., Li, X., Hao, P. P., Feng, X., Chen, Y. G., & Yun, Z. (2010). Angiotensin II type 1 receptor gene A1166C polymorphism and essential hypertension in Chinese: a meta-analysis. J. Renin Angiotensin Aldosterone Syst, 11, 127–135. doi: 10.1177 / 1470320310364181.
  4. Kato, N., Tatara, Y., Ohishi, M., Takeya, Y., Onishi, M., Maekawa, Y., & Rakugi, H. (2011). Angiotensin-converting enzyme single nucleotide polymorphism is a genetic risk factor for cardiovascular disease: a cohort study of hypertensive patients. Hypertension Research, 34(6), 728–734. doi: 10.1038/hr.2011.28.
  5. Ramu, P., Umamaheswaran, G., Shewade, D. G., Swaminathan, R. P., Dutta, T. K., Balachander, J., & Adithan, C. (2011). Candidate gene polymorphisms of renin angiotensin system and essential hypertension in a South Indian Tamilian population. International J. of Human Genetics, 11(1), 31–40. doi: 10.1080/09723757.2011.11886120.
  6. Alqahtani, S. A., Fouad, T. R., & Lee, S. S. (2008). Cirrhotic cardiomyopathy. Semin Liver Dis, 28, 59–69. doi: 10.1055 / s-2008-1040321.
  7. Franchuk, S. V. (2012). Sex features of the development left ventricular myocardial hypertrophy in patients with essential hypertension which suffered from vascular complication when inherit of different variants of angiotensin II type 1 receptor gene. Visnyk Vinnitskogo natsionalnogo medychnogo universitetu, 2(16), 446–452.
  8. Benetos, A., Giron, A., Joly, L., Temmar, M., Nzietchueng, R., Pannier, B., et al. (2013). Influence of the AGTR1 A1166C Genotype on the Progression of Arterial Stiffness: A 16-Year Longitudinal Study. Am. J. Hypertens, 26, 1421–1427. doi: 10.1093/ajh/hpt141.
  9. Mehri, S., Mahjoub, S., Hammami, S., Zaroui, A., Frih, A., Betbout, F., et al. (2012). Renin-angiotensin system polymorphisms in relation to hypertension status and obesity in a Tunisian population. Molecular Biology Reports, 39(4), 4059–4065. doi: 10.1007/s11033-011-1187-2.
  10. Sugawara, A., Takeuchi, K., Uruno, A., Ikeda, Y., Arima, S., Kudo, M., et al. (2001). Transcriptional Suppression of Type 1 Angiotensin II Receptor Gene Expression by Peroxisome Proliferator-Activated Receptor-in Vascular Smooth Muscle Cells. Endocrinology, 142(7), 3125–3134. doi: 10.1210/endo.142.7.8272.

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How to Cite

1.
Babak OY, Zaitseva MM. Assessment of cardiac hemodynamics indicators in patients with arterial hypertension and non-alcoholic fatty liver disease depending on angiotensin II type 1 receptor A1166C gene polymorphism. Zaporozhye Medical Journal [Internet]. 2018May30 [cited 2026May21];20(3). Available from: https://zmj.zsmu.edu.ua/article/view/130462

Issue

Vol. 20 No. 3 (2018)

Section

Original research

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