The effectiveness of Bioleikin in complex treatment of patients with acute diffuse peritonitis

Abstract

In this work the peculiarities of cytokine profile and immune balance in 48 patients with acute diffuse peritonitis, which were divided into two groups, were analized. In patients (n=26) of basic group, as opposed to control one(n=22), complex therapy in postoperative period was extended by the usage of preparation Bioleikin, which was administrated by intravenous infusion in the dose of 500000 IU in a solution of 0.9 % isotonic sodium chloride 400 ml in 48 hours, for four infusions, that resulted in better stabilization of immunogramm, was accompanied by basic group patients’ state improving and led to the decrease of postoperative complications by 20,7 % and lethality - by 8,5%.