Immune checkpoint inhibitors in therapy of non-small cell lung cancer (a review)

Authors

  • O. P. Kolesnik Zaporizhzhia State Medical University, Ukraine, Ukraine
  • V. V. Mykhailychenko Zaporizhzhia State Medical University, Ukraine, Ukraine

DOI:

https://doi.org/10.14739/2310-1210.2021.3.216471

Keywords:

non-small cell lung cancer, immune checkpoint inhibitors, treatment

Abstract

Aim. Based on scientific literature data, to evaluate the effectiveness of the use of immune checkpoint inhibitors (ICI) in the treatment of non-small cell lung cancer (NSCLC).

Materials and methods. To analyze the results of clinical trials of NSCLC treatment with immune checkpoint inhibitors.

Conclusions. Among the immune checkpoint inhibitors, PD-1/PD-L1 inhibitors, namely Nivolumab, Pembrolizumab and Atezolizumab, are most successful in the treatment of NSCLC. Their use significantly increases overall survival and progression-free survival with a lower profile of adverse events. They are prescribed as both second-line and first-line drugs in the NSCLC therapy. Such biomarkers as Teff gene expression level, tumor mutational load (TMB) level and interferon gamma (IFNG) mRNA expression level have also been identified. They allow to more accurately determine the group of patients who will show the best response to therapy with PD-1/ PD-L1 inhibitors.

Author Biographies

O. P. Kolesnik, Zaporizhzhia State Medical University, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Oncology and Oncosurgery

V. V. Mykhailychenko, Zaporizhzhia State Medical University, Ukraine

Student

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Published

2021-06-07

How to Cite

1.
Kolesnik OP, Mykhailychenko VV. Immune checkpoint inhibitors in therapy of non-small cell lung cancer (a review). Zaporozhye Medical Journal [Internet]. 2021Jun.7 [cited 2026May15];23(3):417-24. Available from: https://zmj.zsmu.edu.ua/article/view/216471

Issue

Vol. 23 No. 3 (2021)

Section

Review

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