Synthesis and actoprotective activity of salts of 2-(5-(4-metoxyphenіl (3,4,5-trimetoxyphenyl))-1,2,4-trіazole-3-ylthio)acetic acids
DOI:
https://doi.org/10.14739/2310-1210.2014.2.25459Keywords:
1, 2, 4-triazole, physical-chemical properties, actoprotective activityAbstract
New salts of 2-(5-(4-methoxyphenyl(3,4,5-trimethoxyphenyl))-1,2,4-triazole-3-ylthio)-acetic acids have been synthesized. The structure has been proven and the physical-chemical properties and actoprotective activity of the synthesized compounds have been studied. The relationship between the structure of the obtained salts and actoprotective activity has been detected. Compounds with expressed activity, have been found among the synthesized compounds and can be recommended for further study in order to introduce into medical practice as original medicines.
References
A.I. Gavrev, V.V. Marysheva, P.D. Shabanov. Aktoprotektornoe dejstvie antigipoksantov tiazoloindol'nogo ryada . Actoprotective action antihypoxants tiazoloindolnogo series .Eksperimental'naya i klinicheskaya farmakologiya . - 2010 . T.73, №2. S. 25-30.
Yu.G. Bobkov, V.I. Vinogradov, V.F. Katkov, S.S. Losev, A.V. Smirnov. Farmakologicheskaya korrekciya utomleniya . Pharmacological correction of fatigue . M. Medicina, 1984. 208 s.
P.P. Denisenko. Problema farmakologicheskoj zaschity organizma pri dejstvii `ekstremal'nyh faktorov. Problem pharmacological protection of the organism under the influence of extreme factors. Fizio¬logiya `ekstremal'nyh sostoyanij i individual'naya zaschita cheloveka. M., 1986. S. 330.
O.V. Stefanova. Doklіnіchnі doslіdzhennya lіkars'kih zasobіv. Preclinical studies of drugs. Metodichnі rekomendacії za red. chlen-kor. AMN Ukraїni O.V. Stefanova - K.: Avіcena, 2001. 528 s.
L.A. Kazicyna, N.B. Kupletskaya. Primenenie UF-, IK-, i YaMR-spektroskopii v organicheskoj himii. Application of UV, IR, and NMR Spectroscopy in Organic Chemistry. M. Vyssh. shk., 1971. 264 s.
A.G. Kaplaushenko, V. V. Parchenko, O. І. Panasenko [ta іn.]. Sintez і gostra toksichnіst' solej 2-(5-R-4-R1-1,2,4-trіazol-3-tіo)-2-(karboksimetiltіo)-karbonotіoіl)gіdrazinoacetatnih kislot. . Synthesis and acute toxicity of salts of 2 - (5-R-4-R1-1 ,2,4-triazoles-3-thio) -2 - (carboxymetyltio)-carbonotioil) hidrazynoatsetatnyh acids . Aktual'nі pitannya farmac. ta med. nauki ta praktiki : zb. nauk. st. - Zaporіzhzhya, 2008. - Vip. HHІ, t. 2 (klіnіchna medicina) : materіali Vseukr. nauk.-prakt. konf. z mіzhnar. uchastyu «Suchasnі aspekti medicini і farmacії - 2008». S. 87-92.
A. S . Goculya, Є. G. Knish , І. M. Shevchenko . Sintez ta bіologіchna aktivnіst' solej ta esterіv 2-(5-R-4-(2-metoksifenіl)-1,2,4-trіazol-3-іltіo)acetatnih kislot . Synthesis and biological activity of the salts and esters of 2 - (5-R-4-(2-methoxyphenyl) -1,2,4-triazoles-3-iltio) acetic acid. Lekarstva - cheloveku. Sovremennye problemy sozdaniya, issledovaniya i aprobacii lekarstvennyh sredstv : materialy nauch.-prakt. konf., 22 ber. 2007 r. X., 2007. S. 25-26.
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