Lymphoproliferative disorder – Castleman’s disease with early childhood-onset in a child (a clinical case)

Authors

  • O. M. Mukvich SI “Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0001-6405-4997
  • N. M. Vdovina SI “Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0003-3949-8857
  • H. I. Klymniuk National Cancer Institute, Kyiv, Ukraine, Ukraine https://orcid.org/0000-0002-8082-0505
  • L. I. Omelchenko SI “Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0003-2989-9278
  • T. A. Hridina SI “Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0002-9234-9896
  • N. B. Matsiuk SI “Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0002-1583-6543

DOI:

https://doi.org/10.14739/2310-1210.2022.6.257594

Keywords:

Castleman’s disease, lymphoproliferative syndrome, IL-6, interferon regulatory factor, genes (IRF8), children

Abstract

Castleman’s disease (angiofollicular lymphoma, giant lymph node hyperplasia, Castleman’s pseudotumor) is an understudied orphan lymphoproliferative disease with a long period of asymptomatic course and a high risk of malignancy, and variability of its clinical features can cause difficulties in diagnosis.

The aim of the study. To acquaint clinicians and increase the effectiveness of early diagnosis and treatment of Castleman’s disease (CD) in children to prevent malignancy and improve prognosis.

Results. The article presents a clinical case of CD in a 3.5-year-old boy with a long history of fever, stunted growth, sweating, arthralgia, anemia, high laboratory inflammatory factors, elevated IL-6. There was a complex diagnostic search except for infectious, immunodeficiency, autoimmune conditions. The diagnosis of hyaline-vascular type of CD was confirmed by immunohistochemical examination after lymph node excisional biopsy. Rapid positive dynamics was noted after radical removal of the lymph node conglomerate. At follow-up after 8 months, the patient met criteria for clinical and laboratory remission.

Conclusions. Castleman’s disease should be included in the search algorithm for lymphoproliferative diseases. Determining the role of genetic mutations in interferon regulatory factor (IRF8) is of scientific interest to clarify the etiology of this disease.

Author Biographies

O. M. Mukvich, SI “Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine”, Kyiv

MD, PhD, DSc, Professor, Head of the Department of Pediatric Rheumatology and Auto-inflammatory Diseases

N. M. Vdovina, SI “Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine”, Kyiv

MD, pediatrician, pediatric cardiorheumatologist

H. I. Klymniuk, National Cancer Institute, Kyiv, Ukraine

MD, PhD, pediatric oncologist, Head of the Research Department of Pediatric Oncology, Chief Specialist of the Ministry of Health of Ukraine in the specialty “Pediatric Oncology”

L. I. Omelchenko, SI “Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine”, Kyiv

MD, PhD, DSc, Professor, Senior Researcher of the Department of Pediatric Rheumatology and Auto-inflammatory Diseases, Honored Worker of Science and Technology of Ukrainе

T. A. Hridina, SI “Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine”, Kyiv

MD, PhD, ultrasound diagnostics specialist

N. B. Matsiuk, SI “Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine”, Kyiv

MD, pediatrician

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Published

2022-12-20

How to Cite

1.
Mukvich OM, Vdovina NM, Klymniuk HI, Omelchenko LI, Hridina TA, Matsiuk NB. Lymphoproliferative disorder – Castleman’s disease with early childhood-onset in a child (a clinical case). Zaporozhye Medical Journal [Internet]. 2022Dec.20 [cited 2026May21];24(6):754-9. Available from: https://zmj.zsmu.edu.ua/article/view/257594

Issue

Vol. 24 No. 6 (2022)

Section

Case Reports

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