The debut of Schamberg disease (a clinical case)
DOI:
https://doi.org/10.14739/2310-1210.2023.2.273497Keywords:
pigmentation disorders, Schamberg purpura, pigmented purpuric dermatoses, pigmentation, skin diseasesAbstract
A group of pigmented purpuric dermatoses includes a list of skin diseases characterized by multiple petechial hemorrhages, purpura, and increased skin pigmentation (yellow, brown, or red patchy).
Schamberg disease is the most common representative of this group with a benign, chronic and recurrent course of idiopathic origin. The lesions are often asymptomatic or associated with mild pruritus, usually occurring on the lower extremities. The diagnosis is not a dilemma, as it is made based on clinical examinations and identification of the classical rash morphology, but is also emphasizing the role of a wide range of specialists in the evaluation and treatment of this pathological condition.
The aim of the study. To analyze a clinical case of the debut of Schamberg disease.
Results. Considering the sporadic nature and rarity of the disease, the clinical case of Schamberg disease diagnosed in a 53-year-old man who visited a pediatrician concerning his child’s illness is presented. The probable cause of the disease debut was a complex trigger effect (a long-term use of diclofenac sodium, drinking alcohol on the eve).
Conclusions. The report is aimed at drawing attention to Schamberg disease (Schamberg purpura) as a diagnostic and therapeutic challenge not only for general practitioners, internal medicine specialists but also for dermatologists, phlebologists, hematologists in particular.
References
Zaldivar Fujigaki, J. L., & Anjum, F. Schamberg Disease. [Updated 2022 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK560532/
Roman, C. V. (1922). Diseases of the Skin and the Eruptive Fevers. Journal of the National Medical Association, 14(4), 285-286.
Tolaymat, L., & Hall, M. R. Pigmented Purpuric Dermatitis. (2022). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK519562/
Sharma, L., & Gupta, S. (2012). Clinicoepidemiological study of pigmented purpuric dermatoses. Indian dermatology online journal, 3(1), 17-20. https://doi.org/10.4103/2229-5178.93486
Torrelo, A., Requena, C., Mediero, I. G., & Zambrano, A. (2003). Schamberg's purpura in children: a review of 13 cases. Journal of the American Academy of Dermatology, 48(1), 31-33. https://doi.org/10.1067/mjd.2003.25
King, T., Woo, P. N., & Barbieri, A. (2016). Unilateral Petechial and Pigmentary Macules in a 12-Year-Old Boy. Pediatric dermatology, 33(3), 351-352. https://doi.org/10.1111/pde.12817
Chayed, Z., Mose, K. F., & Bygum, A. (2020). [Pigmented purpuric dermatoses]. Ugeskrift for laeger, 182(21), V12190682.
Ratnam, K. V., Su, W. P., & Peters, M. S. (1991). Purpura simplex (inflammatory purpura without vasculitis): a clinicopathologic study of 174 cases. Journal of the American Academy of Dermatology, 25(4), 642-647. https://doi.org/10.1016/0190-9622(91)70246-x
Bonnet, U., Selle, C., Isbruch, K., & Isbruch, K. (2016). Recurrent purpura due to alcohol-related Schamberg's disease and its association with serum immunoglobulins: a longitudinal observation of a heavy drinker. Journal of medical case reports, 10(1), 301. https://doi.org/10.1186/s13256-016-1065-6
Schetz, D., & Kocić, I. (2015). A new adverse drug reaction--Schamberg's disease caused by amlodipine administration--a case report. British journal of clinical pharmacology, 80(6), 1477-1478. https://doi.org/10.1111/bcp.12742
Mancano, M. A. (2016). Gastrointestinal Nodules and Bleeding with Long-Term Lanthanum Use; DRESS and Hepatotoxicity Due to Rivaroxaban; Thrombocytopenia Induced by Pentoxifylline; Amlodipine-Induced Schamberg's Disease; Varenicline-Induced Acute Liver Injury. Hospital pharmacy, 51(4), 284-287. https://doi.org/10.1310/hpj5104-284
Koçak, A. Y., Akay, B. N., & Heper, A. O. (2013). Sildenafil-induced pigmented purpuric dermatosis. Cutaneous and ocular toxicology, 32(1), 91-92. https://doi.org/10.3109/15569527.2012.702838
Abeck, D., Gross, G. E., Kuwert, C., Steinkraus, V., Mensing, H., & Ring, J. (1992). Acetaminophen-induced progressive pigmentary purpura (Schamberg's disease). Journal of the American Academy of Dermatology, 27(1), 123-124. https://doi.org/10.1016/s0190-9622(08)80826-2
Kanwar, A. J., & Thami, G. P. (1999). Familial Schamberg's disease. Dermatology, 198(2), 175-176. https://doi.org/10.1159/000018101
Tristani-Firouzi, P., Meadows, K. P., & Vanderhooft, S. (2001). Pigmented purpuric eruptions of childhood: a series of cases and review of literature. Pediatric dermatology, 18(4), 299-304. https://doi.org/10.1046/j.1525-1470.2001.01932.x
Spigariolo, C. B., Giacalone, S., & Nazzaro, G. (2021). Pigmented Purpuric Dermatoses: A Complete Narrative Review. Journal of clinical medicine, 10(11), 2283. https://doi.org/10.3390/jcm10112283
Kim, D. H., Seo, S. H., Ahn, H. H., Kye, Y. C., & Choi, J. E. (2015). Characteristics and Clinical Manifestations of Pigmented Purpuric Dermatosis. Annals of dermatology, 27(4), 404-410. https://doi.org/10.5021/ad.2015.27.4.404
Ozkaya, D. B., Emiroglu, N., Su, O., Cengiz, F. P., Bahali, A. G., Yildiz, P., Demirkesen, C., & Onsun, N. (2016). Dermatoscopic findings of pigmented purpuric dermatosis. Anais brasileiros de dermatologia, 91(5), 584-587. https://doi.org/10.1590/abd1806-4841.20165124
Schober, S. M., Peitsch, W. K., Bonsmann, G., Metze, D., Thomas, K., Goerge, T., Luger, T. A., & Schneider, S. W. (2014). Early treatment with rutoside and ascorbic acid is highly effective for progressive pigmented purpuric dermatosis. Journal of the German Society of Dermatology : JDDG, 12(12), 1112-1119. https://doi.org/10.1111/ddg.12520
Martínez Pallás, I., Conejero Del Mazo, R., & Lezcano Biosca, V. (2020). Pigmented Purpuric Dermatosis: A Review of the Literature. Dermatosis purpúricas pigmentadas. Revisión de la literatura científica. Actas dermo-sifiliograficas, 111(3), 196-204. https://doi.org/10.1016/j.ad.2019.02.013
Plachouri, K. M., Florou, V., & Georgiou, S. (2019). Therapeutic strategies for pigmented purpuric dermatoses: a systematic literature review. The Journal of dermatological treatment, 30(2), 105-109. https://doi.org/10.1080/09546634.2018.1473553
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. 
