Reimplantation of the left renal vein in case of nutcracker syndrome: a 25-year experience of one center

Authors

DOI:

https://doi.org/10.14739/2310-1210.2024.3.299558

Keywords:

vascular compression syndrome, surgical procedures, long-term outcomes

Abstract

The aim was to assess the long-term outcomes of the left renal vein reimplantation in case of nutcracker syndrome.

Materials and methods. The study included 56 patients with critical stenosis of the left renal vein who underwent left renal vein reimplantation from May 1999 to August 2023. 10 patients were operated on between 1999 and 2013, that provided an opportunity to study long-term outcomes in the period from 7 to 21 years (a retrospective part). 46 patients underwent the surgery between 2018 and 2023 (a prospective part).

Results. According to the long-term outcome analysis of the left renal vein reimplantation conducted in the period from 3 months to 21 years, all the patients reported a gradual regression of clinical symptoms, namely, resolution of pain syndrome, hematuria, proteinuria, erectile dysfunction, dyspeptic phenomena. Ultrasonography detected a statistically significant increase in the left renal vein diameter from 1.90 ± 0.87 mm to 7.50 ± 0.76 mm (p = 0.0123) in the aorto-mesenteric segment after the surgery and a statistically significant decrease in the peak systolic velocity from 187.30 ± 2.95 cm/sec to 38.70 ± 0.76 cm/sec (p = 0.0178) in this area. A statistically significant decrease in the left gonadal vein diameter from 6.60 ± 1.30 to 4.20 ± 0.84 mm (p = 0.0118) after the surgery was noted and a decrease in the left kidney parenchymal thickness from 2.20 ± 0.46 to 1.60 ± 0.54 mm (p = 0.0123) was observed.

Conclusions. Reimplantation of the left renal vein has been proven to be an effective treatment for critical stenosis of the left renal vein.

Author Biographies

I.I. Kobza, Danylo Halytsky Lviv National Medical University, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Surgery No. 2

I. R. Nesterenko, Ivano-Frankivsk National Medical University, Ukraine

MD, PhD, Assistant of the Department of General and Vascular Surgery

References

  1. Nastasi DR, Fraser AR, Williams AB, Bhamidi V. A systematic review on nutcracker syndrome and proposed diagnostic algorithm. J Vasc Surg Venous Lymphat Disord. 2022;10(6):1410-6. doi: https://doi.org/10.1016/j.jvsv.2022.08.003
  2. Nesterenko ІR. Treatment of aorta mesenteric compression: current problems and prospects. Art of Medicine. 2021;(3):36-42. doi: https://doi.org/10.21802/artm.2021.3.19.36
  3. Duncan AA. How I treat nutcracker syndrome. J Vasc Surg Cases Innov Tech. 2023;9(4):101344. doi: https://doi.org/10.1016/j.jvscit.2023.101344
  4. Charondo LD, Hamouche F, Stoller M. The Journey and Barriers to Treatment of Patients With Renal Nutcracker Syndrome. Urology. 2022;169:250-5. doi: https://doi.org/10.1016/j.urology.2022.08.013
  5. St Hilaire C, Paisley M, Greene J, Casey KM. Left renal vein transposition for posterior Nutcracker syndrome. J Vasc Surg Cases Innov Tech. 2021;7(2):243-6. doi: https://doi.org/10.1016/j.jvscit.2021.02.016
  6. Fitzpatrick S, Dunlap E, Schweitzer E, Phelan M, Nagarsheth K. Surgical treatment of nutcracker syndrome results in improved pain and quality of life. J Vasc Nurs. 2023;41(4):235-9. doi: https://doi.org/10.1016/j.jvn.2023.10.001
  7. Sarikaya S, Altas O, Ozgur MM, Hancer H, Yilmaz F, Karagoz A, et al. Treatment of Nutcracker Syndrome with Left Renal Vein Transposition and Endovascular Stenting. Ann Vasc Surg. 2024;102:110-20. doi: https://doi.org/10.1016/j.avsg.2023.11.036
  8. Franco-Mesa C, Gloviczki P, Erben Y. Nutcracker syndrome. J Cardiovasc Surg (Torino). 2021;62(5):467-71. doi: https://doi.org/10.23736/S0021-9509.21.11923-8
  9. Rista E, Llambro M, Lazaj J, Aliu D, Saliaj K. Endovascular treatment of nutcracker syndrome. Kidney Int. 2022;102(4):942. doi: https://doi.org/10.1016/j.kint.2022.04.038
  10. Kolber MK, Cui Z, Chen CK, Habibollahi P, Kalva SP. Nutcracker syndrome: diagnosis and therapy. Cardiovasc Diagn Ther. 2021;11(5):1140-9. doi: https://doi.org/10.21037/cdt-20-160
  11. Fuentes-Perez A, Bush RL, Kalra M, Shortell C, Gloviczki P, Brigham TJ, et al. Systematic review of endovascular versus laparoscopic extravascular stenting for treatment of nutcracker syndrome. J Vasc Surg Venous Lymphat Disord. 2023;11(2):433-41. doi: https://doi.org/10.1016/j.jvsv.2022.10.001
  12. Cronan JC, Hawkins CM, Kennedy SS, Marshall KW, Rostad BS, Gill AE. Endovascular management of nutcracker syndrome in an adolescent patient population. Pediatr Radiol. 2021;51(8):1487-96. doi: https://doi.org/10.1007/s00247-021-04986-0
  13. Avgerinos ED, Saadeddin Z, Humar R, Salem K, Singh M, Hager E, et al. Outcomes of left renal vein stenting in patients with nutcracker syndrome. J Vasc Surg Venous Lymphat Disord. 2019;7(6):853-9. doi: https://doi.org/10.1016/j.jvsv.2019.06.016
  14. Maharaj D, Mohammed SR, Caesar K, Dindyal S. Nutcracker syndrome: a case-based review. Ann R Coll Surg Engl. 2023 Dec 1. doi: https://doi.org/10.1308/rcsann.2023.0090
  15. D'Oria M, Zlatanovic P, Anthony A, Dua A, Flores AM, Tanious A, et al. International Union of Angiology consensus document on vascular compression syndromes. Int Angiol. 2023;42(4): 282-309. doi: https://doi.org/10.23736/S0392-9590.23.05100-3

Downloads

Published

2024-05-31

How to Cite

1.
Kobza I, Nesterenko IR. Reimplantation of the left renal vein in case of nutcracker syndrome: a 25-year experience of one center. Zaporozhye Medical Journal [Internet]. 2024May31 [cited 2026May21];26(3):200-3. Available from: https://zmj.zsmu.edu.ua/article/view/299558

Issue

Section

Original research