The role of carbohydrate malabsorption syndrome in the pathogenesis of rotavirus diarrhea (a literature review)

Authors

DOI:

https://doi.org/10.14739/2310-1210.2024.4.302524

Keywords:

rotavirus infection, pathogenesis, diarrhea, carbohydrate malabsorption syndrome, lactase deficiency, children

Abstract

The aim – to summarize literature data on the pathogenetic mechanisms of the diarrheal syndrome development in children with rotavirus infection and to determine the role of carbohydrate malabsorption syndrome in it through a complex analysis of literature reviews and empirical studies.

Rotavirus infection (RVI) remains the main cause of severe dehydrating gastroenteritis in children under five years of age. One of the most important pathogenetic links of rotavirus gastroenteritis is the development of osmotic diarrhea induced by carbohydrate malabsorption syndrome. Its development is associated with disaccharidase insufficiency and impaired absorption of monosaccharides in the small intestine.

Carbohydrate malabsorption syndrome is found in 67.0–98.3 % of children with RVI. Its laboratory manifestations (an increase in levels of fecal carbohydrates and lactose) are observed starting from the first days of the disease, and the maximum indicators are recorded in the period from the fifth to the seventh day.

Conclusions. Carbohydrate malabsorption syndrome is observed in the absolute majority of children with RVI, and its maximum severity is noted from the fifth to the seventh day of the disease, being realized mainly due to lactase deficiency. The severity of carbohydrate malabsorption syndrome can be influenced by concomitant pathological conditions, that lead to a decrease in the activity of disaccharidases in the small intestine, and the metabolic activity of the intestinal microbiota.

Author Biographies

O. V. Usachova, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Pediatric Infectious Diseases

N. V. Vorobiova, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

MD, PhD, Assistant of the Department of Pediatric Infectious Diseases

E. A. Silina, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

MD, PhD, Assistant of the Department of Pediatric Infectious Diseases

T. B. Matvieieva, CNE “Zaporizhzhia Regional Clinical Hospital of Infectious Diseases” of Zaporizhzhia Regional Council, Ukraine

MD, Head of the Department No. 4

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2024-07-17

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1.
Usachova OV, Vorobiova NV, Silina EA, Matvieieva TB. The role of carbohydrate malabsorption syndrome in the pathogenesis of rotavirus diarrhea (a literature review). Zaporozhye Medical Journal [Internet]. 2024Jul.17 [cited 2026May13];26(4):325-30. Available from: https://zmj.zsmu.edu.ua/article/view/302524

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Vol. 26 No. 4 (2024)

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Review

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