Currently, the issue of increased dentin sensitivity after operations for hard dental tissue preparation during the therapeutic treatment of the carious process, as well as during orthopedic treatment of various types with non-removable dentures, has retained its relevance. Pain management is the prevention of postoperative complication development and ensures high-quality treatment results.

Aim. The purpose of the literature review in this paper was to draw specialists’ attention to the use of low-solvent adhesive systems of various types to manage postoperative sensitivity of hard dental tissues.

Materials and methods. More than 30 literature sources focused on studying action mechanisms of known generations of dental adhesive systems and their effects on changes in postoperative sensitivity of dental hard tissues as a result of a high-quality protective film formation on the dentin surface have been analyzed.

Results. The use of various adhesive systems to reduce postoperative sensitivity of soft tissues with the formation of a high-quality protective film on the dentin surface that seals the dentinal tubules is of great importance for obtaining qualitative treatment results and increasing its effectiveness. However, various reactive substances (solvents, acetone), which are components of most adhesives, have a strong impact on their quality and significantly reduce the indications for their use.

Conclusions. Thus, studying the action mechanisms of adhesives on dental tissues, searching for the formulation of new adhesive systems with a lower solvent content would expand the indications for their use as therapeutic and prophylactic drugs to reduce pain sensitivity of hard dental tissues after preparation.