The aim of the study to assess the resistance of infectious complication pathogens to antibacterial drugs in patients after major liver resection (MLR) with or without biliary obstruction.

Material and methods. A total of 105 patients were assigned to 2 groups: group 1 consisted of 53 patients (7 – with hepatocellular carcinoma (HCC), 28 – with cholangiocarcinoma (CC), 18 – with metastases of colorectal cancer) with biliary obstruction; group 2 – 52 patients (25, 10 and 17, respectively) without biliary obstruction.

Results. A microbiological examination of urine, blood, sputum, bile, pharyngeal and wound samples was performed after MLR.

Conclusions. Patients with HCC and CC with biliary obstruction after MLR had infectious complications in 100.0 % of cases, patients without biliary obstruction – in 25.7%; Gram-positive microorganisms were statistically significantly more often isolated from them: Enterococcus faecalis in 17.1 % (р1,2 = 0.01); gram-negative microorganisms: Escherichia coli in 5.7 % (р1,2 = 0.05), hemolytic Escherichia coli in 5.7 % (р1,2 = 0.05), Pseudomonas aeruginosa in 5.7 % (р1,2 = 0.05); fungi in 8.6 % (р1,2 = 0.04); significantly more often, Enterococcus faecalis was isolated from blood in 5.7 % (р1,2 = 0.05), Enterococcus faecium – from urine in 8.6 % (р1,2 = 0.05), Candida albicans – from wounds in 5.7 % (р1,2 = 0.05) and sputum in 8.6 % (р1,2 = 0.02).