Оцінювання регенераторної здатності залишкової частки печінки у живих родинних донорів після донорської правобічної гемігепатектомії

I. O. Kotenko; O. I. Dronov

doi:10.14739/2310-1210.2025.5.340579

Authors

I. O. Kotenko Medical Center, Universal Clinic “Oberig”, Kyiv, Ukraine https://orcid.org/0000-0002-9917-1314
O. I. Dronov Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0001-9639-6721

DOI:

https://doi.org/10.14739/2310-1210.2025.5.340579

Keywords:

donors, liver, right hepatectomy, CT volumetry, liver regeneration

Abstract

Donor right hepatectomy is the standard method of graft procurement in living-related donors. Donor safety depends on adequate regeneration of the remnant liver. Studying the patterns of parenchymal regeneration and functional liver reserve in this category of patients has important clinical significance.

Aim. To evaluate the regenerative capacity of the remnant liver in living-related donors after right hepatectomy.

Materials and methods. A prospective study was conducted including 50 living liver donors who underwent right hepatectomy. Liver volumes were assessed using CT volumetry preoperatively and on postoperative days 14 and 90. The study was conducted in accordance with the principles of the Declaration of Helsinki. The protocol was approved by the institutional bioethics committee, and informed consent was obtained from all participants

Results. The mean remnant liver volume was 448.7 ± 93.9 ml preoperatively, 833.0 ± 176.1 ml on day 14, and 943.2 ± 160.3 ml on day 90. A statistically significant increase was observed on both day 14 and day 90 (p < 0.001). The increase relative to baseline was +85.6 % at day 14 and +110.2 % at day 90.

Conclusions. The liver of living donors demonstrates a high regenerative potential after right hepatectomy, with restoration of adequate parenchymal volume within the first three months postoperatively.

Author Biographies

I. O. Kotenko, Medical Center, Universal Clinic “Oberig”, Kyiv

MD, Surgeon, Transplantologist, Department of Liver, Pancreas and Transplantation Surgery

O. I. Dronov, Bogomolets National Medical University, Kyiv

MD, PhD, DSc, Professor, Head of the Department of General Surgery No. 1

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