Serum cystatin C as a marker of glomerular kidney damage in patients with chronic glomerulonephritis with saved renal function
DOI:
https://doi.org/10.14739/2310-1210.2015.3.44455Keywords:
Glomerulonephritis, Glomerular, Cystatin CAbstract
Improving of glomerular damage diagnostics in chronic glomerulonephritis (CGN) is an actual theme.
Aim. To analyze indicators of glomerular kidney damage in CGN patients.
Methods and results. We examined 81 patients with CGN and saved renal function to analyze indicators of glomerular kidney damage according to vivo morphological kidney study in CGN patients with and without arterial hypertension (AH) and relationship between serum cystatin C (CysC) and histological parameters.
Conclusion. Patients with hypertension had more expressed indicators of glomerular damage than patients without hypertension. We demonstrated that serum cysC is a marker of glomerular kidney damage in patients with CGN.
References
Kolesnyk, M. O., Saidakova, N. O., Kozliuk, N. I., Vladziievska, H. S., & Kulyzkii, M. V. (2011). Medyko-profilaktychna dopomoha khvorym nefrolohichnoho profiliu v Ukraini [Medical and preventive care to patients of renal profile in Ukraine]. Ukrainskii zhurnal nefrolohii і dializu, 4 (32), 3–11. [in Ukrainian].
Fasset, R. G., Venuthurupalli, К. S., Glenda, C. G., Coombes, J. S., Cooper, M. A., & Hoy, W. E. (2011). Biomarkers in chronic kidney disease: a review. Kidney Int., 80, 806–821. doi: 10.1038/ki.2011.198.
Proletov, Ya. Yu., Saganova, E. S., Galkina, O. V., Zubina, I. M., Bogdanova, E. O., Sipovskii, V. G., & Smirnov, A. V. (2013). Rol' nekotoryh biomarkerov v ocenke kharaktera khronicheskogo povrezhdenija pochek u pacientov s pervichnymi glomerulopatiyami [The role of several biomarkers in estimation of kidney injury in patients with primary glomerulopathies]. Nefrologiya, 17(1), 60–69. [in Russian].
Hojs, R., Bevc, S., Ekart, R., Gorenjak, M., & Puklavec, L. (2008). Serum cystatin C-based equation compared to serum creatinine-based equations for estimation of glomerular filtration rate in patients with chronic kidney disease. Clin. Nephrol., 70(1), 7–10.
Coppo, R., & Cattran, D. (2010). The new oxford clinic-pathological classification of IgA nephropathy. Sec. Biol. Med. Sci., XXXI (1), 241–248.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.