The spectrum of pathogens and their resistance in patients with malignant liver and biliary tract tumors with biliary obstruction after extensive liver resections

Authors

DOI:

https://doi.org/10.14739/2310-1210.2024.5.310543

Keywords:

liver, liver tumors, liver resections, infectious, complications, antibiotic resistance microbial

Abstract

The aim of the study to assess the resistance of infectious complication pathogens to antibacterial drugs in patients after major liver resection (MLR) with or without biliary obstruction.

Material and methods. A total of 105 patients were assigned to 2 groups: group 1 consisted of 53 patients (7 – with hepatocellular carcinoma (HCC), 28 – with cholangiocarcinoma (CC), 18 – with metastases of colorectal cancer) with biliary obstruction; group 2 – 52 patients (25, 10 and 17, respectively) without biliary obstruction.

Results. A microbiological examination of urine, blood, sputum, bile, pharyngeal and wound samples was performed after MLR.

Conclusions. Patients with HCC and CC with biliary obstruction after MLR had infectious complications in 100.0 % of cases, patients without biliary obstruction – in 25.7%; Gram-positive microorganisms were statistically significantly more often isolated from them: Enterococcus faecalis in 17.1 % (р1,2 = 0.01); gram-negative microorganisms: Escherichia coli in 5.7 % (р1,2 = 0.05), hemolytic Escherichia coli in 5.7 % (р1,2 = 0.05), Pseudomonas aeruginosa in 5.7 % (р1,2 = 0.05); fungi in 8.6 % (р1,2 = 0.04); significantly more often, Enterococcus faecalis was isolated from blood in 5.7 % (р1,2 = 0.05), Enterococcus faecium – from urine in 8.6 % (р1,2 = 0.05), Candida albicans – from wounds in 5.7 % (р1,2 = 0.05) and sputum in 8.6 % (р1,2 = 0.02).

Author Biographies

V. P. Romaniuk, Medical Center “Universal Clinic “Oberig”, Kyiv, Ukraine

MD, Postgraduate student of the Department of Internal Diseases, Faculty of Dentistry, Bogomolets National Medical University; General Practitioner, Gastroenterologist, Head of the Infection Control Department

O. H. Kotenko, Medical Center “Universal Clinic “Oberig”, Kyiv, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Liver, Pancreas and Transplantation Surgery

G. A. Solovyova, Bogomolets National Medical University, Kyiv, Ukraine

MD, PhD, DSc, Professor, Acting Head of the Department of Internal Diseases, Faculty of Dentistry

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Published

2024-10-04

How to Cite

1.
Romaniuk VP, Kotenko OH, Solovyova GA. The spectrum of pathogens and their resistance in patients with malignant liver and biliary tract tumors with biliary obstruction after extensive liver resections. Zaporozhye Medical Journal [Internet]. 2024Oct.4 [cited 2026May16];26(5):397-402. Available from: https://zmj.zsmu.edu.ua/article/view/310543

Issue

Vol. 26 No. 5 (2024)

Section

Original research

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