Effect of blood pressure normalization (reaching the target level) on epinephrine-induced platelet aggregation changes in patients with hypertension
DOI:
https://doi.org/10.14739/2310-1210.2017.3.100588Keywords:
hypertension, platelet aggregation, adrenalineAbstract
There is a little data about the impact of blood pressure normalization on platelet aggregation properties and the impact of antihypertensive drugs on platelet hemostasis.
Aim. To study adrenaline-induced platelet aggregation changes in patients with hypertension achieving target blood pressure under the influence of antihypertensive therapy.
Material and Methods. The study involved 149 patients with stage II, second degree EH, who were divided into 2 groups based on target levels of blood pressure. The first group included 48 patients with essential hypertension who achieved target levels of blood pressure, the second group - 101 patients with EH, who have not reached the target blood pressure. Groups of patients were comparable in age. All patients were performed by DMAP and LTA.
Results. Groups EH patients who achieved and did not achieve the target blood pressure were comparable by the types of aggregations. The percentage of "two-phase" aggregation was 19% of the first group patients and 22% of the second group patients (p = 0.675), "drain" 16% and 13% (p = 0.622) respectively, "oppressed" 48% and 56% (p = 0,362) respectively, "missing" 17% and 9% (p = 0.156), respectively. Patients with essential hypertension who have not reached the target level of blood pressure had the "two-phase" curve adrenaline-induced platelet aggregation 36.4% (p = 0.001) greater than the maximum degree of aggregation within 5 minutes of recording, 14.8% (p = 0.009) greater than the maximum degree of aggregation within 10 minutes of recording, 28.3% (p = 0.023) greater degree of aggregation on the third minute, 34.3% (p = 0.002) greater degree of aggregation on the fifth minute, 28 0% (p = 0.009) greater area under the curve of aggregation on the fifth minute, and 21.4% (p = 0.005) on the ten minute than similar rates in patients with EH, who have achieved the target blood pressure.
Conclusions. Achieving target blood pressure in patients with hypertension is accompanied by multidirectional changes of platelets aggregation properties. Normalization of blood pressure in patients with hypertension in 36% of cases is associated with reduced epinephrine-induced platelet aggregation.
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