Interrelation of melatonin with quality of life and personality properties of patients with endometrial pathology in the late reproductive and premenopausal period

Authors

  • S. M. Korniyenko SE Institute pediatrics, obstetrics and gynecology NAMS Ukraine, Kyiv,

DOI:

https://doi.org/10.14739/2310-1210.2017.4.105103

Keywords:

endometritis, melatonin, SF-36 questionnaire, FPI questionnaire

Abstract

The aim of the work is to investigate the relationship of melatonin with the quality of life and the profile of the personality of women of late reproductive and premenopausal age with the pathology of the endometrium.

Materials and methods. 45 women aged 36-55 years with endometrial diseases were examined. All patients underwent hysteroscopy.

The personality profile was assessed using the FPI test. To study the quality of life, the SF-36 questionnaire was used. The data was processed using the Spearman rank correlation.

Results. As a result of the correlation analysis of data on melatonin concentration and SF-36 scales, our study found that the value of melatonin did not affect the quality of life associated with health. However, if we evaluate trends, then the highest of the reduced correlation coefficients is of some interest. It's about role physical functioning.

The correlation coefficients of the melatonin index and the scales of the FPI questionnaire looked as follows: all significant correlation coefficients had a negative sign, that is, the personality properties corresponding to these coefficients were associated with a low concentration of melatonin. The ordering of the FPI scales by decreasing the significance of the correlation coefficients helped to identify the personal profile of hypomelatoninemia in the examined women. First of all, he was characterized by high levels of depressiveness and emotional lability.

Conclusions. In the psychopathological structure of the personality of women of late reproductive and pre-menopausal age with endometrial pathology burdened with hypomelatoninemia, depressive and emotional lability is predominate. Reducing the secretion of melatonin is also associated with increased spontaneous aggressiveness, neuroticism and irritability.

References

Asarnow, L. D., Soehner, A. M., Harvey, A. G. (2013). Circadian rhythms and psychiatric illness. Curr Opin Psychiatry, 26(6), 566–571. doi: 10.1097/YCO.0b013e328365a2fa.

Choi, D. (2013). Potency of melatonin in living beings. Dev Reprod, 17(3), 149–177. doi: 10.12717/DR.2013.17.3.149.

Comai, S., & Gobbi, G. (2014). CCNP Award Paper: Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology. J Psychiatry Neurosci, 39(1), 6–21. doi: 10.1503/jpn.130009.

Courtet, P., & Olié, E. (2012). Circadian dimension and severity of depression. Eur Neuropsychopharmacol., 22(3), 476–481. doi: 10.1016/j.euroneuro.2012.07.009.

Harb, F., Hidalgo, M.P., & Martau, B. (2015). Lack of exposure to natural light in the workspace is associated with physiological, sleep and depressive symptoms. Chronobiol Int., 32(3), 368–375. doi: 10.3109/07420528.2014.982757.

Haridas, S., Kumar, M., & Manda, K. (2013). Melatonin ameliorates chronic mild stress induced behavioral dysfunctions in mice. Physiol Behav, 119, 201–207. doi: 10.1016/j.physbeh.2013.06.015.

Guesdon, V., Malpaux, B., Delagrange, P., Spedding, M., Cornilleau, F., Chesneau, D., Haller, J., & Chaillou, E. (2013). Rapid effects of melatonin on hormonal and behavioral stressful responses in ewes. Psychoneuroendocrinology, 38(8), 1426–1434. doi: 10.1016/j.psyneuen.2012.12.011.

Ito, Y., Iida, T., Yamamura, Y., Teramura, M., Nakagami, Y., Kawai, K., et al. (2013). Relationships between Salivary Melatonin Levels, Quality of Sleep, and Stress in Young Japanese Females. Int J Tryptophan Res, 6(1), 75–85. doi: 10.4137/IJTR.S11760.

Srinivasan, V., DeBerardis, D., Shillcutt, S.D., & Brzezinski, A. (2012). Role of melatonin in mood disorders and the antidepressant effects of agomelatine. Expert OpinInvestig Drugs, 21(10), 1503–1522. doi: 10.1517/13543784.2012.711314.

Sharkey, K. M., Pearlstein, T. B., & Carskadon, M. A. (2013). Circadian phase shifts and mood across the perinatal period in women with a history of major depressive disorder: a preliminary communication. J Affect Disord, 150(3), 1103–1108. doi: 10.1016/j.jad.2013.04.046.

Downloads

How to Cite

1.
Korniyenko SM. Interrelation of melatonin with quality of life and personality properties of patients with endometrial pathology in the late reproductive and premenopausal period. Zaporozhye medical journal [Internet]. 2017Jul.3 [cited 2024Apr.24];(4). Available from: http://zmj.zsmu.edu.ua/article/view/105103

Issue

No. 4 (2017)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)