Study of specific pharmacological activity of standardized composition of bee product substances for treatment of urogenital system
DOI:
https://doi.org/10.14739/2310-1210.2017.5.110237Keywords:
genitourinary system, honey, propolis, bee pollen, apitherapyAbstract
Introduction. The work presents review of the data literature, which indicate the prospects of creation new highly efficient drugs for the treatment of chronic prostatitis and prostate gland adenoma based bioactive standardized substances of bee products, including powdered honey (PH), propolis phenolic hydrophobic drug (PPHD) and bee pollen (BP).
Materials and methods. Results of discussion of preclinical pharmacological studies of standardized substances of bee products composition – PH, PPHD and BP for the treatment of specified pathology is given in the experimental part.
Results. It was found that the most pronounced anti-inflammatory effect on the level 40 % the mixture of APIs (PH, PPHD and BP) detects at a dose of 100 mg/kg in relation to the reference drug – trianom capsules in doses of 100 and 130 mg/kg.
Conclusions. Usage of bee products is grounded in creation of the new drug on their basis in the form of standardized substances of bee products composition –PH, PPHD and BP for chronic prostatitis and prostate gland adenoma. It was found that the most pronounced anti-inflammatory effect on 40 % the mixture of APIs (PH, PPHD and BP) detects at a dose of 100 mg/kg. It was established that the composition of standard substances of bee products – PH, PPHD and BP at a dose of 100 mg/kg shows a more pronounced specific pharmacological effect in comparison to the reference product – trianom capsules at doses of 100 and 130 mg/kg, which positively affect the course of the pilot prostatitis in male rats caused by dichloroethyl.
References
Arslanov, M. M., Kamalov, I. I., & Fattakhov, V. V. (2011) Fizioterapevticheskie metody lecheniya khronicheskogo prostatita [Physiotherapy treatment of chronic prostatitis]. Prakticheskaya medicina, 1(49), 22–24. [in Russian].
Sharykina, N. I. (Ed) (2013) Derzhavnyi reiestr likarskykh zasobiv Ukrainy. Kyiv. Retrieved from http://www.drlz.kiev.ua. [in Ukrainian].
Solihov, D. N. (2009) Vobenzim v lechenii khronicheskogo bakterial'nogo prostatita [Vobenzim and treatment of chronic prostatitis]. Doklady akademii nauk Respubliki Tadzhikistan, 52(5), 400–402. [in Russian].
Bratchikov, O. I., Shestakov, S. G., Shumakova, E. A., & Makhov, S. V. (2008) The increase of clinico-immunological efficiency in complex therapy of patients with chronic prostatitis. Urology, 2, 44–49.
Al’-Shukri, S. Kh., Petlenko, S. V., Borovets, S. Yu., Rybalov, M. A., Soroka, I. V., & Stukan’, N. I. (2016) Effect of Prostatilene® AC and Prostatilene® on the ejaculate level of antisperm antibodies in the treatment of patients with chronic abacterial prostatitis and concomitant reproductive dysfunctions. Andrology and genital surgery, 1(17), 40–43. doi: http://dx.doi.org/10.17650/2070-9781-2016-17-1-40-43.
Tikhonov, A. I., Tikhonova, S. A., Yarnykh, T. G., Shpychak, O. S., et al. (2010) Med natural'nyj v medicine i farmacii (proiskhozhdenie, svojstva, primenenie, lekarstvennye preparaty) [Honey natural in medicine and pharmacy (origin, properties, applications, medicinal products)]. Kharkiv: Original. [in Russian].
Tichonov, A. I., Jarnych, T. G., Czernych, W. P. et al. (2005) Teoria i praktyka wytwarzania leczniczych preparatow propolisowych. Khrakov: Marka.
Tichonow, A. I., Sodzawiczny, K., Tichonowa, S. A., Jarnych, T. G., Bondarczuk, L. I., & Kotenko, A. M. (2008) Pylek kwiatowy obnoze pszczele w farmacji i medycynie. Teoria, technologia, zastosowanie lecznicze. Krakow: Apipol-Pharma.
Shpychak, O. S. (2016) Teoretychne ta eksperymentalne obhruntuvannia skladu і rozrobka tehnolohіi lіkarskykh apіpreparatіv dlia zastosuvannia u sportyvnіi medytsynі. (Avtoref. dis… dokt. farm. nauk) [Theoretical and experimental study of composition and development of medical technology apipreparativ for use in sports medicine Dr. fharm. sci. diss.]. Kharkiv. [in Ukrainian].
Shpychak, О. S., Tykhonov, O. I., Zupanets, I. A., & Shebeko, S. K. (2015) The experimental study of the anti-inflammatory properties of combined aerosols with the propolis phenolic hydrophobic drug. The Pharma Innovation, 3(11), 2629.
Shpychak, О.S., Tykhonov, O.I., Zupanets, I.A., Shebeko, S.K. (2015) The study of the analgesic properties of combined aerosols with the propolis phenolic hydrophobic drug in the experiment. The Pharma Innovation, 4(3), 78-81.
Spychak, O. S., Tykhonov, O. I., Kotov, A. H., et al. (2014) Med [Honey]. Derzhavna farmakopeia Ukrainy, (Vol. 2), (P. 436–439). Kharkiv: Derzhavne pidpryiemstvo «Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv» [in Ukrainian].
Tykhonov, O. I., Yudin, O. I., Yarnykh, T. H., Shpychak, O. S., et al. (2015) TUU 10.8–39834691–001:2015 Med poroshkopodibnyi [Powdered honey]. Kyiv. [in Ukrainian].
Yudin, O. I. (2010) Innovacionnye tekhnologii i konstruktivnye osobennosti oborudovaniya dlya polucheniya pischevykh poroshkov [Innovative technologies and design features of equipment for obtaining food powders]. Kharkiv. [in Russian].
Stefanov, O. V. (Ed) (2001) Doklinichni doslidzhennia likarskykh zasobiv [Preclinical studies of drugs]. Kyiv: Avіtsenna. [in Ukrainian].
Yakovleva, L. V. (1992) Poisk i izuchenie novykh NPVP – proizvodnykh dikarbonovykh kislot (Dis… dokt. farm. nauk) [Search and study of new NSAID – derivatives of dicarboxylic acids. Dr. farm. sci. diss.] Kharkiv. [in Russian].
Kovalenko, V. N. (Ed) (2017) Kompendium 2015 – lekarstvennye preparaty [Compendium 2016 – medicines]. Kyiv: MORION. [in Russian].
Karateev, A. E., Uspensky, Yu. P., Pakhomova, I. G., & Nasonov, E. L. (2012) Kratkij kurs istorii NPVP [A concise course of the history of NSAIDs]. Nauchno-prakticheskaya revmatologiya, 3(52), 101–106. [in Russian].
Zaharevskij, A. S. (1962) Vliyanie nekotorykh proizvodnykh indola na nervnuyu sistemu (Dis…kand. med. nauk) [Influence of some indole derivatives on the nervous system. Dr. med. sci. diss. Minsk. [in Russian].
Shpychak, О. S., & Tikhonov, O. I. (2014) Eksperymentalne doslidzhennia spetsyfichnoi farmakolohichnoi dii kombinovanoho heliu «Artproment» [The experimental study of the specifi c pharmacological action of «Artproment®» combined gel]. Zaporozhye medical journal, 4(85), 103–106. [in Ukrainian].
Lar'yanovskaya, Yu. B., Dranova, I. N., Kishinec, N. V., Dzyuba, I. P., & Butenko, I. G. (1999) Holodovaya travma predstatel'noj zhelezy krysy kak e´ksperimental'naya model' prostatita [Cold injury of the prostate gland of the rat as an experimental model of prostatitis]. Proceedings of the V National Congress of Pharmacists of Ukraine. Kharkiv: Prapor. [in Russian].
Bomko, T. V., Maslova, N. F., Kozlova, N. G., Dolgaya, I. N., & Pyatikop, A. B. (2002) Famakologicheskoe izuchenie suppozitoriev s maslom semyan tykvy na modeli e´ksperimental'nogo prostatita [Pharmacological study of suppositories with pumpkin seed oil on the model of experimental prostatitis]. Visnyk farmatsii, 2(30), 90–92. [in Russian].
Gus`kov, A. R. (2008) Istoki khronicheskogo prostatita [The origins of chronic prostatitis]. Moscow: Medica. [in Russian].
Bent, H. H. (2002) The biochemistry and medical significance of the flavonoids. Pharmacology and Therapeutics, 96(2–3), 167–202. doi: 10.1016/S0163-7258(02)00298-X.
Serov, V. V., & Paukov, V. S. (1995) Vospalenie. Rukovodstvo dlya vrachej [Inflammation. Guidlines for doctors]. Moscow: Medicina. [in Russian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
