Current concepts of maxillitis pathogenesis and morphogenesis

Authors

  • I. M. Andreichyn I. Horbachevsky Ternopil State Medical University, Ukraine,
  • V. A. Mikhniov Bogomolets National Medical University, Kyiv, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2018.02.125358

Keywords:

maxillary sinusitis, pathology, confounding factors

Abstract

The aetiology of prenatal sinusitis as well as maxillitis is caused by bacteria, micromyces and viruses, often in combination. Acute infection spreads predominantly from meatus to paranasal sinuses resulting in rhinosinusitis development. Natural sinus fistula obstruction due to mucous membrane oedema, endotoxicosis, disorders of tissue immunity and mucociliary clearance, leukocytic infiltration, stimulation of oxygen active forms formation in leukocytes etc. are significant for the disease pathogenesis. As a result, inflammatory and dystrophic changes develop in all layers of sinus walls. The pathological process is affected by a number of confounding factors.

The aim of the research is to study the recent research publications for better comprehension of the main factors of maxillitis aetiology and pathogenesis taking into account our research data.

Conclusions. Maxillitis is caused by pathogenic and potentially pathogenic bacteria, fungi and viruses, which are usually spread to sinuses from meatus. Endotoxicosis, the decrease in tissue immunity and mucociliary clearance, inflammatory and dystrophic changes in mucosae and bone layer of sinus walls are very important for the pathogenesis. The significance of neurotrophic disorders is proven. The confounding factors take account of immunodeficiency, cryoglobulinemia, sinus fistula obstruction, adenoidal vegetation, anatomical anomalies of nose, hepatic insufficiency.

References

Byrjalsen, A., Ovesen, T., & Kjaergaard, T. (2014). Staphylococcus aureus is a major pathogen in severe acute bacterial rhinosinusitis. Rhinology, 52(1), 48–52. doi: 10.4193/Rhin.

Dong, D., Thomas, N., Thierry, B., Vreugde, S., Prestidge, C. A., & Wormald, P.-J. (2015). Distribution and Inhibition of Liposomes on Staphylococcus aureus and Pseudomonas aeruginosa Biofilm. PLoS One., 10(6), е. 0131806. doi: 10.1371/journal.pone.0131806.

Eviatar, E., Sandbank, J., Kleid, S., & Gavriel, H. (2014). The role of osteitis of the lamina papyracea in the formation of subperiosteal orbital abscess in young children. International Journal of Pediatric Otorhinolaryngology, 78(12), 2267–2337. doi: 10.1016/j.ijporl.2014.10.031.

Andreychyn, Yu. M., Klymnyuk, S. I., & Pokryshko, O. V. (2014). Mikroflora verkhnoshchelepnykh pazukh i yii adhezyvna aktyvnist pry hostromu hniinomu synusyti [Microflora of the maxillary sinus and its adhesive activity in acute purulent sinusitis]. Infektsiini khvoroby, 3, 69–73. [in Ukrainian].

Jain, R., Singhal, S. K., Singla, N., Punia, R. S., & Chander, J. (2015). Mycological Profile and Antifungal Susceptibility of Fungal Isolates from Clinically Suspected Cases of Fungal Rhinosinusitis in a Tertiary Care Hospital in North India. Mycopathologia, 180(1–2), 51–60. doi: 10.1007/s11046-015-9873-6.

Popovich, V. I., & Koshcel, I. V. (2013). Porivnialna efektyvnist roslynnoho fitonirynhovoho preparatu z kompleksnoiu diieiu ta syntetychnoho protyzapalnoho zasobu v likuvanni ditei z nehniinymy formamy hostroho rynosynuitu [Comparative effectiveness of herbal phytoneering drug with a complex action and synthetic anti-inflammatory drugs in treating children with acute purulent rhinosinusitis]. Rynolohiia, 3, 25–31. [in Ukrainian].

Maliarenko, T. V. (2009). Dosvid zastosuvannia preparatu «Fromilid-uno» pry bakterialnykh rynosynuitakh [The experience of using the drug «Fromilid-Uno» duringbacterial rhino sinusitis]. Zhurnal vushnykh, nosovykh i horlovykh khvorob, 3, 74–77. [in Ukrainian].

Podovzhnii, O. H., Sonnik, N. B., & Loburets, A. V. (2013). Rynohenni ta odontohenni verkhnoshchelepni synusyty: osoblyvosti diahnostyky [Rhinogenic and odontogenic maxillary sinusitis: features ofdiagnosis]. Zhurnal vushnykh, nosovykh i horlovykh khvorob, 5, 177–178. [in Ukrainian].

Talalaеnko, I. A., & Boenko, S. K. (2010). Izmeneniya ostiomeatal'nogo kompleksa u pacientov s khronicheskimi vospalitel'nymi zabolevaniyami perednej gruppy okolonosovykh pazukh [Alterations of osteometal complex in patients with chronic inflammatory disease of frontal paranasal sinuses]. Zhurnal vushnykh, nosovykh i horlovykh khvorob, 6, 30–35. [in Russian].

Zavalii, M. A., & Bezshapochny, S. B. (2010). Analiz klinicheskikh simptomov i fiziko-khimicheskikh pokazatelej funkcii mukocilyarnoj transportnoj sistemy u bol'nykh ostrym gnojnym sinusitom [Analysis of clinical symptoms and physicochemical parameters of mucociliary transport system function in patients with acute purulent sinusitis]. Rynolohіia, 4, 3–14. [in Russian].

Demenkov, V. R., Pristavko, T. M., & Vatanskaya, I. Yu. (2012). Mestnoe i obshchee lechenie bol'nykh s ostrymi gnojnymi sinusitami [Local and general treatment of patients with acute purulentsinusitis]. Zhurnal vushnykh, nosovykh i horlovykh khvorob, 5, 48–49. [in Russian].

Kosakovskij, A. L., & Bezshapochnyj, S. B. (2010). Pro zastosuvannia preparativ «Umkalor» ta «Tsynabsyn» pry likuvanni khvorykh na hostryi rynosynusyt [About application of preparations «Umckalor» and «Cinnabsin» at the treatment of the patients with acute rhinosinusitis]. Zhurnal vushnykh, nosovykh i horlovykh khvorob, 6, 36–41. [in Ukrainian].

Anfuso, A., Ramadan, H., Terrell, A., Demirdag, Y., Walton, C., Skoner, D. P., & Piedimonte, G. (2015). Sinus and adenoid inflammation in children with chronic rhinosinusitis and asthma. Annals of Allergy, Asthma and Immunology, 114(2), 103–110. doi: 10.1016/j.anai.2014.10.024.

Evcimik, M. F., Dogru, M., Cirik, A. A., & Nepesov, M. I. (2015). Adenoid hypertrophy in children with allergic disease and influential factors. International Journal of Pediatric Otorhinolaryngology, 79(5), 694–697. doi: 10.1016/j.ijporl.2015.02.017.

Dutta, R., Dubal, P. M., & Eloy, J. A. (2015). The connection between seasonal allergies, food allergies, and rhinosinusitis: what is the evidence? Current Opinion in Otolaryngology & Head and Neck Surgery, 23(1), 2–7. doi: 10.1097/MOO.0000000000000123.

Doellman, M., Chen, P. G., McMains, K. C., Sarber, K. M., & Weitzel, E. K. (2015). Sinus penetration of saline solution irrigation and atomizer in a cadaveric polyp and allergic fungal sinusitis model. Allergy Rhinology. (Providence), 6(1), 8–11. doi: 10.2500/ar.2015.6.0115.

Madani, S. A., & Hashemi, S. A. (2014). Characterisation of up-regulated immunoglobulins in patients with chronic rhinosinusitis. The Journal of the Pakistan Medical Association, 64(4), 382–387.

Yoon, Y. H., Jin, K., Kwon, K. R., Kim, S. H., Rha, K. S., & Kim, Y. M. (2014). The role of B cell Activating Factor (BAFF) expression on pathogenesis of nasal polyp in chronic rhinosinusitis with nasal polyposis. Rhinology, 52(4), 390–396. doi: 10.4193/Rhin13.154.

Andreichyn, Yu. M. (2014). Aktyvni formy kysniu pry poiednanni verkhnoshchelepnoho synusytu i toksychnoho hepatytu v eksperymenti [Oxygen active forms combined with maxillary sinusitis and toxic hepatitis in experiment]. Hepatolohiia, 1, 61–66. [in Ukrainian].

Van Zele, T., Holtappels, G., Gevaert, P., & Bachert, C. (2014). Differences in initial immunoprofiles between recurrent and nonrecurrent chronic rhinosinusitis with nasal polyps. The American Journal of Rhinology & Allergy, 28(3), 192–200. doi: 10.2500/ajra.2014.28.4033.

Otto, B. A., & Wenzel, S. E. (2008). The role of cytokines in chronic rhinosinusitis with nasal polyps. Current Opinion in Otolaryngology & Head and Neck Surgery, 16(3), 270–4. doi: 10.1097/MOO.0b013e3282fb2885.

Volkov, I. K. (2007). Antioksidantnaya terapiya pri khronicheskikh zabolevaniyakh legkikh u detej [Antioxidant therapy at chronic diseases of the lungs in children]. Pediatriya (prilozhenie k zhurnalu «Consilium Medicum»), 9(1), 43–44. [in Russian].

Bezshapochnyi, S. B., Hasiuk, Yu. A., & Balynskyi, V. O. (2013). Morfolohichni zminy u stromi nazalnykh polipiv [Morphological changes in the stroma of nasal polyps]. Zhurnal vushnykhykh, nosovykh i horlovykh khvorob, 3, 17–18. [in Ukrainian].

Andreychyn, Yu. M. (2011). Klinichna otsinka hiperekspresii faktora Villebranda pry verkhnoshchelepnomu synusyti [Clinical evaluation of von willebrand factor at maxillary sinusitis]. Infektsiini khvoroby, 2, 54–56. [in Ukrainian]. doi: http://dx.doi.org/10.11603/1681-2727.2011.2.578.

Andreychyn, Yu. M. (2014). Trombomodulin yak marker endotelialnoi funktsii khvorykh na verkhnoshchelepnyi synusyt [Thrombomodulin as marker of endothelial function in patients whis maxillary sinusitis]. Zdobutky klinichnoi i eksperymentalnoi medytsyny, 2, 209–211. [in Ukrainian].

Coffey, C. S., Mulligan, R. M., & Schlosser, R. J. (2009). Mucosal expression of nerve growth factor and brain-derived neurotrophic factor in chronic rhinosinusitis. The American Journal of Rhinology & Allergy, 23(6), 571–575. doi: 10.2500/ajra.2009.23.3412.

Mikhnev, V. A., Kolomijceva, V. P., & Fedotov, A. F. (1972). Nejrotroficheskie izmeneniya slizistoj obolochki pridatochnykh pazukh nosa krolikov pri e'ksperimental'nom narushenii simpaticheskoj innervacii [Neurotrophic changes in the mucous membrane of the rabbitsʼ nose paranasalsinuses with experimental disturbances of sympathetic innervation]. Zhurnal vushnykhykh, nosovykh i horlovykh khvorob, 2, 76–80. [in Russian].

Mikhnev, V. A., Andreichyn, Yu. M., & Datsko, T. V. (2014). Morfolohichni zminy slyzovoi obolonky verkhnoshchelepnykh synusiv morskykh svynok pry eksperymentalnomu porushenni yii sympatychnoi innervatsii [Morphological changes in the mucous membrane of the maxillary sinuses of guinean pigs in experimental disruption of sympathetic innervation]. Zhurnal Natsionalnoi akademii medychnykh nauk Ukrainy, 1, 109–114. [in Ukrainian].

Andreychyn, Yu. M. (2014). Modeliuvannia slyzovoi obolonky verkhnoshchelepnykh synusiv na tli toksychnoho hepatytu v eksperymenti [Experimental modeling of the mucosa maxillary sinusitis against on toxic hepatitis b]. Infektsiini khvoroby, 4, 61–63. [in Ukrainian].

Downloads

How to Cite

1.
Andreichyn IM, Mikhniov VA. Current concepts of maxillitis pathogenesis and morphogenesis. Zaporozhye medical journal [Internet]. 2018Mar.7 [cited 2024Apr.19];(2). Available from: http://zmj.zsmu.edu.ua/article/view/125358

Issue

No. 2 (2018)

Section

Review

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)