Functional state of the pituitary-adrenal system in women with rheumatism

Authors

  • S. Ye. Kosilova Higher state educational institution of Ukraine "Bukovina State Medical University", Chernivtsi,

DOI:

https://doi.org/10.14739/2310-1210.2018.4.135810

Keywords:

pregnancy, adrenocorticotropic hormone, cortisol

Abstract

Objective: to study peculiarities of the pituitary-adrenal system reactivity during pregnancy and delivery in women suffering from rheumatism depending on the rheumatoid process activity and heart failure (HF) degree.

Materials and methods: the level of adrenocorticotropic hormone (ACTH) and cortisol before delivery and in the dynamics of delivery among women suffering from rheumatism and healthy ones.

Results. The functional state of the pituitary-adrenal system in pregnant women and women in childbirth suffering from rheumatism was found to be disturbed. Delivery in patients with inactive phase of rheumatic process with CHF stage I occurs with more tension of the pituitary gland and adrenal cortex functional activity which is evidenced by higher content of ACTH and cortisol in the peripheral blood. Stressful situations during delivery in patients with active phase of rheumatic process result in marked tension of the pituitary-adrenal system of the maternal organism. Associated severe insufficiency of blood circulation leads to the exhaustion of the reserved adrenal cortex capabilities which is manifested by a decreased cortisol level in the blood of women in childbirth.

Conclusions. Pathologic decrease in ACTH and cortisol levels in the blood of women in childbirth suffering from rheumatism is indicative of disturbed processes of adaptation to stressful childbirth-related effect and chronic hypoxia.

 

 

 

References

Vatutin N.T. (2012). Diagnostika i lechenie ostroj i hronicheskoj serdechnoj nedostatochnosti: novoe v rekomendaciyah European Society of Cardiologi (2012). [Diagnosis and treatment of acute and chronic heart failure: new in the recommendations of the European Society of Cardiologi (2012)]. Praktychna anhiolohiia, 7–8(56–57). Retrieved from https://angiology.com.ua/ru-issue-article-501#Diagnostika-i-lechenie-ostroy-i-hronicheskoy-serdechnoy-nedostatochnosti-novoe-v-rekomendaciyah-European-Society-of-Cardiology- [in Russian].

Olshevska, O. V. (2017). Funktsionalni mozhlyvosti hipofizarno-nadnyrnykovoi systemy u rodil z poiednanoiu pre eklampsiieiu [Functional possibilities of the pituitary-adrenocortical system in parturients with concomitant preeclampsia]. Ukrainskyi zhurnal khіrurhіi, 2(33), 45–49. [in Ukrainian]. doi: 10.22141/1997-2938.2.33.2017.107650.

Kosilova, S. Ye. (2017). Sostoyanie processov perekisnogo okisleniya lipidov i antioksidantnoj zashchity krovi u rozhenic s revmatizmom [The condition of the processes of lipid peroxidation and antioxidant defense of the blood in parturient women with rheumatism]. Zaporozhskij medicinskij zhurnal, 1(100), 63–66. [in Russian]. doi: 10.14739/2310-1210.2017.1.91712.

Meerson, F. Z. (1993). Adaptacionnaya medicina: zashchitnye perekrestnye e'ffekty adaptacii [Adaptation medicine: protective cross-effects of adaptation]. Moscow : Medicina. [in Russian].

Khudaverdyan, A. D. (2015). Soderzhanie kortizola v krovi zhenshchin v razlichnye periody razvitiya beremennosti i dejstviya khronicheskogo stressa [Cortisol levels in blood of pregnant women in different stages of pregnancy and chronic stress influence]. Medicinskaya nauka Armenii, 55(2), 123–127.

Glover, V. T. (2015) Prenatal stress and its effects on the fetus and child: possible underlying biological mechanisms. Adv. Neurobiol., 10, 269–83. doi: 10.1007/978-1-4939-1372-5_13.

O'Donnell, K. J., Bugge Jensen, A., Freeman, L., Khalife, N., O'Connor, T. G., & Glover, V. (2012) Maternal prenatal anxiety and downregulation of placental 11β – HSD2. Psychoneuroendocrinology, 37(6), 818–26. doi: 10.1016/j.psyneuen.2011.09.014

Khudaverdyan, A. D. (2016). Osobennosti kolebanij urovnya AKTG v krovi beremennykh zhenshchin s vysokim urovnem trevozhnosti i u ikh novorozhdennykh [Specific feature of blood ACTH level fluctuations in pregnant women with high anxiety level and in their newborns]. Akusherstvo i ginekologiya, 2, 78–82. doi: 10.18565/aig.2016.2.78-82.

Glover, V., Bergman, K., Sarkar, R., O’Connor, T. G. (2009) Association between maternal and amniotic fluid cortisol is moderated by maternal anxiety. Psychoneuroendocrinology, 34(3), 430–5. doi: 10.1016/j.psyneuen.2008.10.005.

Riecher-Rossler, A., & Steiner M. (Eds.) (2005) Prenatal stress, mood and anxiety disordens: from bench to bedside. Basel, Paris, London, New York.

Seckl, J. R. (2008) Glucocorticoids, developmental “programming” and the risk of affective dysfunction. Prog. Brain Res., 167, 17–37. doi: 10.1016/S0079-6123(07)67002-2.

Downloads

How to Cite

1.
Kosilova SY. Functional state of the pituitary-adrenal system in women with rheumatism. Zaporozhye Medical Journal [Internet]. 2018Jul.13 [cited 2024Jul.23];(4). Available from: http://zmj.zsmu.edu.ua/article/view/135810

Issue

No. 4 (2018)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)