Features of left ventricular remodeling in hypertension patients with comorbid gout

Authors

  • I. O. Daniuk Zaporizhzhia State Medical University, Ukraine,
  • S. Ya. Dotsenko Zaporizhzhia State Medical University, Ukraine,
  • D. G. Rekalov Zaporizhzhia State Medical University, Ukraine,
  • I. V. Chorna Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2018.5.141684

Keywords:

gout, hypertension, left ventricle remodeling

Abstract

Gout is the most common cause of inflammatory arthritis in men elder than 30 years. The association of gout with hypertension is up to 80 % of cases. Study of cardiovascular system remodeling is very relevant.

Aim. To compare the left ventricle remodeling features in patients with hypertension combined with primary gout and patients with essential hypertension without disorders of purine metabolism.

Materials and methods. 50 men with hypertension manifested on the gout background, 30 men with essential hypertension without disorders of purine metabolism and 20 healthy men were examined. The main parameters of left ventricle were determined using echocardioscopy.

Results. The statistically significant increase in volumetric parameters of the left ventricle in patients with hypertension on the gout background in contrast to the comparison groups and significant decrease in ejection fraction as compared to healthy men were found. The significant increase in left ventricular mass, myocardial mass index and diastolic left ventricle dysfunction in patients with gout were revealed. Using the multivariate analysis of variance we determined an effect of hypertension degree, gout duration and abdominal obesity presence on the process of left ventricle remodeling. The increase in serum uric acid concentration correlated with an increase in left ventricular mass and myocardial mass index. The most of patients with hypertension and gout had the concentric left ventricular hypertrophy.

Conclusions. Arterial hypertension on the gout background is characterized by a significant increase in left ventricular mass and myocardial mass index and the prevalence of concentric hypertrophy pattern of left ventricular geometric remodeling in comparison to patients with essential hypertension. Significant increase in myocardial stiffness and its diastolic dysfunction occurred in patients with hypertension on the gout background. Concentration of serum uric acid correlates with the increase in left ventricular mass and myocardial mass index.

 

References

Roddy E., & Choi, H. K. (2014). Epidemiology of gout. Rheum Dis Clin North Am., 40(2), 155–175. doi: 10.1016/j.rdc.2014.01.001.

Ragab, G., Elshahaly, M., & Bardin, T. J. (2017). Gout: An old disease in new perspective: a review. Adv Res., 8(5), 495–511. doi: 10.1016/j.jare.2017.04.008.

Dalbeth, N., Merriman, T. R., & Stamp, L. K. (2016) Gout. Lancet, 388(10055), 2039–2052. doi: 10.1016/S0140-6736(16)00346-9.

Thottam, G. E., Krasnokutsky, S., & Pillinger, M. H. (2017). Gout and Metabolic Syndrome. Curr Rheumatol Rep., 19(10), 60. doi: 10.1007/s11926-017-0688-y.

Mortada, I. (2017) Hyperuricemia, Type 2 Diabetes Mellitus, and Hypertension: an Emerging Association. Curr Hypertens Rep., 19(9), 69. doi: 10.1007/s11906-017-0770-x.

Elfishawi, M. M., Zleik, N., Kvrgic, Z., Michet, C. J., Crowson, C. S., Matteson, E. L., & Bongartz T. (2018) The Rising Incidence of Gout and the Increasing Burden of Comorbidities: A Population-based Study over 20 Years. J Rheumatol., 45(4), 574–579. doi: 10.3899/jrheum.170806.

Choi, H. K., Soriano, L. C., Zhang, Y., & Rodrіguez, L. A (2012). Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case control study. BMJ, 344, d8190. doi: 0.1136/bmj.d8190.

Andres, M., Bernal, J. A., Sivera, F., Quilis, N., Carmona, L., Vela, P., & Pascual, E. (2017) Cardiovascular risk of patients with gout seen at rheumatology clinics following structured assessment. Ann Rheum Dis., 76(7), 1263–1268. doi: 10.1136/annrheumdis-2016-210357.

Zamudio-Cuevas, Y., Hernández-Díaz, C., Pineda, C., Reginato, A. M., Cerna-Cortés, J. F., Ventura-Ríos, L., & López-Reyes, A. (2015). Molecular basis of oxidative stress in gouty arthropathy. Clin Rheumatol., 34(10), 1667–72. doi: 10.1007/s10067-015-2933-y.

Borghi, C., Rosei, E. A., Bardin, T., Dawson, J., Dominiczak, A., Kielstein, J. T., et al. (2015). Serum uric acid and the risk of cardiovascular and renal disease. J Hypertens., 33(9), 1729–41. doi: 10.1097/HJH.0000000000000701.

Krishnan, E., Hariri, A., Dabbous, O., & Pandya, B. J. (2012). Hyperuricemia and the echocardiographic measures of myocardial dysfunction. Congest Heart Fail., 18(3), 138–143. doi: 10.1111/j.1751-7133.2011.00259.x.

Markelova, E. I., Korsakova, J. O., & Barskova, V. G. (2013). Gipertrofiya miokarda levogo zheludochka u bol'nykh podagroj [Left ventricular hypertrophy in patients with gout]. Sibirskij medicinskij zhurnal. 116(1), 52–58. [in Russian].

Pan, K. L., Lin, J. C., Lin, C. L., Chen, M. C., Chang, P. J., Hsiao, J. F., & Chang, S. T. (2014). The effects of gout on left atrial volume remodelling: a prospective echocardiographic study. Rheumatology (Oxford), 53(5), 867–74. doi: 10.1093/rheumatology/ket444.

Kushnarenko, N. N. (2012). Serdechno-sosudistye narusheniya u muzhchin s podagroj: klinicheskie osobennosti, mekhanizmy razvitiya, prognozirovanie (Avtoref. dis… dokt. med. nauk) [Cardiovascular disorders in men with gout: clinical features, mechanisms of development, prediction. Dr. med. sci. diss.]. Chita [in Russian].

Downloads

How to Cite

1.
Daniuk IO, Dotsenko SY, Rekalov DG, Chorna IV. Features of left ventricular remodeling in hypertension patients with comorbid gout. Zaporozhye Medical Journal [Internet]. 2018Sep.24 [cited 2024Nov.23];(5). Available from: http://zmj.zsmu.edu.ua/article/view/141684

Issue

No. 5 (2018)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)