Assessment of quality of life among women with polycystic ovary syndrome of different reproductive age


  • L. V. Pakharenko State Higher Educational Establishment “Ivano-Frankivsk National Medical University”, Ukraine,
  • V. D. Vorobii State Higher Educational Establishment “Ivano-Frankivsk National Medical University”, Ukraine,
  • N. Yа. Kurtash State Higher Educational Establishment “Ivano-Frankivsk National Medical University”, Ukraine,
  • O. M. Perkhulyn State Higher Educational Establishment “IvanoFrankivsk National Medical University”, Ukraine,



polycystic ovary syndrome, age groups, quality of life


Polycystic ovary syndrome (PCOS) is one of the most problematic neuroendocrine syndromes in gynecology. It affects 6–25 % of reproductive-age women.

Aim of research. To assess the quality of life in women with PCOS in early and active reproductive age.

Materials and methods. The basic group consisted of 90 women with PCOS and was divided into the I and II subgroups. 60 women aged 18–25 years formed the I subgroup, 30 patients aged 26–35 years – the II one. 30 women without this pathology were controls. Diagnosis of PCOS was based on theRotterdam criteria. Quality of life was assessed with the help of the 36-Item Short Form Health Survey.

Results. The parameters of quality of life physical component in women of the basic group were slightly less than in controls. Statistically significant difference was determined only in persons of the II subgroup on the “Physical Functioning” and “General Health” scores by 11.59 % (P = 0.039) and 15.98 % (P = 0.026) lower, respectively, compared to controls. More pronounces and significant decrease in quality of life was found in parameters of the psychological component, especially the “Vitality” and “Social functioning” scores were by 16.51 % (P = 0.021) and 23.12 % (P < 0.001) lower, respectively, compared to healthy women. The overall scores of quality of life were lower in persons of the II subgroup than in I.

Conclusions. Decrease in quality of life is typical for women with PCOS. No significant difference was detected in the physical component score of quality of life between persons with PCOS and controls in the early reproductive age. Though, “Physical Functioning” and “General Health” scores were statistically lower in patients of active reproductive age compared to healthy individuals. However, a decrease in the psychological component of quality of life is typical for women with PCOS, especially for persons of the active reproductive age compared to those of the early one.


Setji, T. L., & Brown, A. J. (2014). Polycystic ovary syndrome: update on diagnosis and treatment. Am J Med, 127 (10), 912–919. doi: 10.1016/j.amjmed.2014.04.017.

Escobar-Morreale, H. F. (2018). Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol, 14(5), 270–284. doi: 10.1038/nrendo.2018.24.

Kakoly, N. S., Khomami, M. B., Joham, A. E., Cooray, S. D., Misso, M. L., Norman, R. J., et al. (2018). Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression. Hum Reprod Update., 24(4), 455–467. doi: 10.1093/humupd/dmy007.

Böttch, B., Fessler, S., Friedl, F., Toth, B., Walter, M. H., Wildt, L., & Riedl, D. (2017). Health-related quality of life in patients with polycystic ovary syndrome: validation of the German PCOSQ-G. Arch Gynecol Obstet, 297(4), 1027–1035. doi: 10.1007/s00404-017-4623-2.

Borghi, L., Leone, D., Vegni, E., Galiano, V., Lepadatu, C., Sulpizio, P., & Garzia, E. (2018). Psychological distress, anger and quality of life in polycystic ovary syndrome: associations with biochemical, phenotypical andsocio-demographic factors. J Psychosom Obstet Gynaecol, 39(2), 128–137. doi: 10.1080/0167482X.2017.1311319.

Balikci, A., Erdem, M., Keskin, U., Bozkurt Zincir, S., Gülsün, M., Özçelik, F., et al. (2014). Depression, Anxiety, and Anger in Patients with Polycystic Ovary Syndrome. Noro Psikiyatr Ars, 51(4), 328–333. doi: 10.5152/npa.2014.6898.

Khomami, M. B., Tehrani, F. R., Hashemi, S., Farahmand, M., & Azizi, F. (2015). Of PCOS symptoms, hirsutism has the most significant impact on the quality of life of Iranian women. PLoS One, 10(4), e0123608. doi: 10.1371/journal.pone.0123608.

Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. (2004). Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome. Fertil Steril, 81, 19–25. doi:

Kaczmarek, C., Haller, D. M., & Yaron, M. (2016). Health-Related Quality of Life in Adolescents and Young Adults with Polycystic Ovary Syndrome: A Systematic Review. J Pediatr Adolesc Gynecol, 29(6), 551–557. doi: 10.1016/j.jpag.2016.05.006.

ZareMobini, F., Kazemi, A., & Farajzadegan, Z. (2018). A comprehensive mental health care program for women with polycystic ovary syndrome: protocol for a mixed methods study. Reprod Health, 15(1), 46. doi: 10.1186/s12978-018-0488-5.

Bazarganipour, F., Ziaei, S., Montazeri, A., Foroozanfard, F., Kazemnejad, A., & Faghihzadeh, S. (2014). Health-related quality of life in patients with polycystic ovary syndrome (PCOS): a model-based study of predictive factors. J Sex Med, 11(4), 1023–1032. doi: 10.1111/jsm.12405.

Panico, A., Messina, G., Lupoli, G. A., Lupoli, R., Cacciapuoti, M., Moscatelli, F., et al. (2017). Quality of life in overweight (obese) and normal-weight women with polycystic ovary syndrome. Patient Prefer Adherence, 11, 423–429. doi: 10.2147/PPA.S119180.

Shishehgar, F., Ramezani Tehrani, F., Mirmiran, P., Hajian, S., & Baghestani, A. R. (2016). Comparison of the Association of Excess Weight on Health Related Quality of Life of Women with Polycystic Ovary Syndrome: An Age- and BMI-Matched Case Control Study. PLoS One, 11(10), e0162911. doi: 10.1371/journal.pone.0162911.

Tziomalos, K., & Dinas, K. (2018). Obesity and Outcome of Assisted Reproduction in Patients With Polycystic Ovary Syndrome. Front Endocrinol (Lausanne), 9, 149. doi: 10.3389/fendo.2018.00149.

Palomba, S., Falbo, A., Daolio, J., Battaglia, F. A., & Sala, G. B. (2018). Pregnancy complications in infertile patients with polycystic ovary syndrome: updated evidences. Minerva Ginecol, doi: 10.23736/S0026-4784.18.04230-2.

Tan, J., Wang, Q. Y., Feng, G. M., Li, X. Y., & Huang, W. (2017). Increased Risk of Psychiatric Disorders in Women with Polycystic Ovary Syndrome in Southwest China. Chin Med J (Engl), 130(3), 262–266. doi: 10.4103/0366-6999.198916.


How to Cite

Pakharenko LV, Vorobii VD, Kurtash NY, Perkhulyn OM. Assessment of quality of life among women with polycystic ovary syndrome of different reproductive age. Zaporozhye medical journal [Internet]. 2019Feb.8 [cited 2024Feb.21];(1). Available from:



Original research