Synthesis of 2-alkylamino-4-methylquinoline-6-r’-phenyl­sulfamides and their antimicrobial activity

Authors

  • T. O. Oleksiyenko
  • I. S. Grytsenko
  • T. P. Osolodchenko

DOI:

https://doi.org/10.14739/2310-1210.2013.2.15611

Keywords:

quinoline, aminoquinoline, sulfamide, synthesis, antimicrobial activity

Abstract

Series of new 2-alkylamino-4-methylquinoline-6-phenylsulfamides was obtained by the reaction of 2-chloro-4-methylquinoline-6-phenylsulfamides with appropriate aliphatic amines in conditions of microwave radiation and their physical and chemical characteristics were studied. The results of microbiological screening revealed that the synthesized compounds showed high activity against Gram-positive microorganisms and C. albicans, but revealed less active effect against gram-negative microorganisms. Some «structure-activity» relationships have been found.

Downloads

How to Cite

1.
Oleksiyenko TO, Grytsenko IS, Osolodchenko TP. Synthesis of 2-alkylamino-4-methylquinoline-6-r’-phenyl­sulfamides and their antimicrobial activity. Zaporozhye Medical Journal [Internet]. 2013Jul.16 [cited 2024Nov.2];15(2). Available from: http://zmj.zsmu.edu.ua/article/view/15611

Issue

No. 2 (2013): Zaporozhye medical journal

Section

Problems of pharmacy

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)