Functional condition of the endothelium in men with primary gout and initial signs of renal dysfunction

Authors

  • I. O. Daniuk Zaporizhzhia State Medical University, Ukraine,
  • S. Ya. Dotsenko Zaporizhzhia State Medical University, Ukraine,
  • D. H. Rekalov Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2019.2.161500

Keywords:

gout, endothelium, chronic renal failure

Abstract

 

Background. Among the causes of mortality in patients with gout, cardiovascular complications and chronic renal failure are prevailed. The searching for the markers of the initial signs of endothelial and renal dysfunction is relevant for the early diagnosis of target organs damage.

Objective. To determine the indicators of endothelial dysfunction in men with primary gout with normal glomerular filtration rate (GFR) and men with stage 1 chronic renal failure (CRF).

Materials and methods. 30 men with primary gout and GFR > 90 ml / min, 30 men with primary gout and GFR = 89–60 ml / min and 30 healthy men were examined. We determined the concentration of endothelin-1 (ET-1), vascular cell adhesion molecule-1 (VCAM-1), total nitric oxide metabolites (NO), serum cystatin C, level of albuminuria and endothelium-dependent vasodilatation (EDVD).

Results. An increase in NO, ET-1, VCAM-1, cystatin C and normal values of EDVD and albuminuria were found in men with primary gout and normal GFR in comparison to the control. In patients with gout and CRF (stage 1), a significant increase in ET-1, VCAM-1, cystatin C, albuminuria and a decrease in NO and EDVD were detected compared to the men with primary gout and GFR >90 ml / min.

Conclusions. Patients with primary gout and normal GFR are characterized by NO hyperproduction providing the vasomotor endothelial function preservation. An increase in the level of cystatin C in these patients compared to the healthy men indicates the beginning of renal filtration function deterioration. Patients with gout and CRF (stage 1) are characterized by significant impairment of vasomotor endothelial function, an increased synthesis of pro-inflammatory markers and a decreased NO production.

 

References

Wang,Yu., & Xiaorong, Bao (2013). Effects of uric acid endothelial dysfunction early chronic kidney disease and its mechanisms. Eur. J. Med. Res., 18(1), 26. doi: 10.1186/2047-783X-18-26

Johnson, R. J., Nakagawa, T., Jalal, D., Sánchez-Lozada, L. G., Kang, D. H., & Ritz, E. (2013). Uric acid and chronic kidney disease: which is chasing which? Nephrol. Dial. Transplant., 28(9), 2221–2228. doi: 10.1093/ndt/gft029

Lottmann, K., Chen, X., & Schаdlich, P. K. (2012). Association between gout and all-cause as well as cardiovascular mortality: a systematic review. Curr. Rheumatol. Rep., 14(2), 195–203. doi: 10.1007/s11926-011-0234-2

Pristrom, A. M., & Benhamed, M. (2012). Oksidativnyj stress i serdechno-sosudistye zabolevaniya. Chast' I [Oxidative stress and cardiovascular diseases. Part I]. Lechebnoe delo: nauchno-prakticheskij terapevticheskij zhurnal, 1(23), 21–28. [in Russian].

Storch, A. S., de Mattos, J. D., Alves, R., dos Santos Galdino, I., & Rocha, H. N. M. (2017). Methods of Endothelial Function Assessment: Description and Applications. International Journal of Cardiovascular Sciences, 30(3), 262–273. http://dx.doi.org/10.5935/2359-4802.20170034

Steyers, C. M., & Miller, F. J. Jr. (2014) Endothelial Dysfunction in Chronic Inflammatory Diseases. Int. J. Mol. Sci., 15(7), 11324–49. doi: 10.3390/ijms150711324

Rajendran, P., Rengarajan, T., Thangavel, J., Nishigaki, Y., Sakthisekaran, D., Sethi, G., & Nishigaki, I. (2013). The Vascular Endothelium and Human Diseases. Int. J.Biol.Sci., 9(10), 1057–69. doi: 10.7150/ijbs.7502

Zhen, H., & Gui, F. (2017). The role of hyperuricemia on vascular endothelium dysfunction. Biomed. Rep.,7(4), 325–330. doi:10.3892/br.2017.966

Romi, M. M., Arfian, N., Tranggono, U., Setyaningsih, W. A. W., & Sari, D. C. R. (2017). Uric Acid Causes Kidney Injury Through inducing fibroblast expansion, Endothelin-1 expression, and inflammation. B.M.C Nephrol., 18(1), 326. doi: 10.1186/s12882-017-0736-x

Stakhova, T. Iu., Shcherbak, A. V., Kozlovskaia, L. V., Taranova, M. V., & Balkarov, I. M. (2014). Clinical value of the determination of markers forendothelial dysfunction (endothelin-1, microalbuminuria) and tubulointerstitialtissuelesion (β2-microglobulin, monocytechemotactic protein-1) in hypertensive patients with uric acid metabolic disorders. TerArkh., 86(6), 45–51.

Roughley, M. J., Belcher, J., Mallen, C. D., & Roddy, E. (2015) Gout Risk Of Chronic Kidney Disease and nephrolithiasis: meta-analysis of observational studies. Arthritis Res Ther, 17, 90. doi: 10.1186/s13075-015-0610-9

Sinyachenko, O. V. (2006). Podagricheskaya nefropatiya [Gouty nephropathy]. Doneck: Yugo-Vostok. [in Russian].

Kushnarenko, N. N. (2012). Serdechno-sosudistye narusheniya u muzhchin s podagroj: klinicheskie osobennosti, mekhanizmy razvitiya, prognozirovanie (Avtoref. dis… dokt. med. nauk) [Clinical and pathogenetic significance of the violation of vascular-platelet hemostasis and microcirculation indices in patients with primary gout Dr. med. sci. diss.]. Chita. [in Russian].

Shangina, A. M. (2012). Kliniko-patogeneticheskoe znachenie narusheniya sosudisto-trombocitarnogo gemostaza i pokazatelej mikrocirkulyacii u bol'nykh pervichnoj podagroj (Avtoref. dis… dokt. med. nauk) [Clinical and pathogenetic significance of the violation of vascular-platelet hemostasis and microcirculation indices in patients with primary gout Dr. med. sci. diss.]. Chita [in Russian].

Shlipak, M. G., Matsushita, K., Arnlov, J., Inker, L. A., Katz, R., Polkinghorne, K. R., et al. (2013). Cystatin C Versus Creatinine In Determining risk based on Kidney function. N.Engl. J.Med., 369(10), 932–43. doi: 10.1056/NEJMoa1214234

Svensson-Färbom, P., Ohlson Andersson, M., Almgren, P., Hedblad, B., Engström, G., Persson, M., et al. (2014). Cystatin C Identifies cardiovascular risk better than Creatinine-based estimates glomerular filtration in middle-aged individual without a history of cardiovascular disease. J.Intern.Med., 275(5), 506–21. doi: 10.1111/joim.12169

Kurapova, M. V. (2015). Kliniko-diagnosticheskoe znachenie e'ndotelial'noj disfunkcii u bol'nykh khronicheskoj bolezn'yu pochek (Dis… dokt. med. nauk). [Clinical and diagnostic value of endothelial dysfunction in patients with chronic kidney disease. Dr. med. sci. diss.]. Samara. [in Russian].

How to Cite

1.
Daniuk IO, Dotsenko SY, Rekalov DH. Functional condition of the endothelium in men with primary gout and initial signs of renal dysfunction. Zaporozhye Medical Journal [Internet]. 2019Apr.2 [cited 2024Nov.13];(2). Available from: http://zmj.zsmu.edu.ua/article/view/161500

Issue

Section

Original research