Comparative study of the effectiveness of antihistamine preparations in the treatment of patients with atopic dermatitis


  • N. Yu. Reznichenko Zaporizhzhia State Medical University, Ukraine,



antihistamines, atopic dermatitis, treatment



The objective of the study – to determine the comparative effectiveness of І-generation antihistamines and active metabolites of II-generation in treatment of patients with atopic dermatitis. Materials and methods. The study included 40 patients with atopic dermatitis. SCORAD scale was used for the assessment of the disease severity and Ukrainian translation of the Dermatology Life Quality Index – for the quality of life assessment. Patients were randomized into two groups that received I generation antihistamines and active metabolites of the II generation. Student's criterion or Wilcoxon criterion was used for statistical analyses. Normality of data distribution was verified using Shapiro–Wilk criterion.Results. A high ΔSCORAD (%) was observed in patients, who used I generation antihistamines. The significantly higher DLQI was in the group which used active metabolites of the II generation. ΔDLQI (%) was significantly lower in patients from the comparison group compared with individuals from the main group. Significant differences in neuroticism and state anxiety were obtained in patients from main and comparative groups with lower values in patients taking I generation antihistamines. In the group of patients before the start of treatment, the state of subdepression was noted, and in those of the main group there were no depressive symptoms at the end of the course of therapy. Conclusions. First-generation antihistamines are more effective in the treatment of atopic dermatitis compared to the active metabolites of second-generation, as evidenced by significant differences in SCORAD, ΔSCORAD (%), the severity of pruritus between groups of patients after completion of treatment. I-generation antihistamines indirectly have a positive effect on the quality of life, anxiety, depression and neuroticism, which explains the need for their priority choice in the treatment of atopic dermatitis.


Kutasevych, Y. F., & Stuliy, O. N. (2014). Terapevticheskaya e'ffectivnost' proizvodnogo khinuklidinov pri allergodermatozakh i nekotorykh drugikh dermatozakh, soprovozhdautschihsya zudom [Medical effectiveness chinuclidine derivative during allergic dermatoses and other allergic dermatoses with itching]. Dermatolohiia ta venerolohiia, 1, 42–51. [in Russian].

Reznichenko, N. Yu. (2013) Zminy metabolizmu u cholovikiv zriloho viku, khvorykh na khronichni alerhichni zakhvoriuvannia shkiry [Changes in metabolism in males of mature age, who suffer from chronic allergic skin diseases]. Visnyk naukovyhk doslidzhen, 3, 16–20. [in Ukrainian].

Reznichenko, N. Yu. (2013) Stan sympato-adrenalovoi ta vahoinsuliarnoi system u cholovikiv zriloho viku, khvorykh na alerhodermatozy [The state of the sympathoadrenal and vagoinsular systems in men of mature age, who suffer fromallergic dermatoses]. Tavricheskij mediko-biologicheskij vestnik, 16(1), 233–236. [in Ukrainian].

Reznichenko, N. Yu. (2013) Znachennia vitaminoprofilaktyky dlia poperedzhennia vynyknennia dermatolohichnoi patolohii ta zberezhennia zdorovia naselennia [The value of vitamin prophylaxis to prevent the emergence of dermatological pathology and to preserve the health of the population]. Zhurnal dermatovenerolohii ta kosmetolohii imeni M. O. Torsuieva, 1–2, 75–80. [in Ukrainian].

Reznichenko, N. Yu. (2017) Chronic allergic skin diseases in men: the influence of age-related dishormonal status. Zaporozhye medical journal, 19(1), 46–49. doi: 10.14739/2310-1210.2017.1.91635

Fujita, H., Nagashima, M., Takeshita, Y., & Aihara, M. (2014) Correlation between nocturnal scratch behavior assessed by actigraphy and subjective/objective parameters in patients with atopic dermatitis. Eur. J. Dermatol., 24(1), 120–122. doi: 10.1684/ejd.2013.2242

Garmhausen, D., Hagemann, T., Bieber, T., Dimitriou, I., Fimmers, R., Diepgen, T., & Novak, N. (2013) Characterization of different courses of atopic dermatitis in adolescent and adult patients. Allergy, 68(4), 498–506. doi: 10.1111/all.12112

Reznichenko, N. Yu. (2013). Alerhichnyi kontaktnyi dermatyt: sychasni uiavlennia pro likuvannia na osnovi ohliadu naukovoi literatury [Allergic contact dermatitis: modern concepts of treatment based on the review of literature]. Current issues in pharmacy and medicine: science and practice, 3(13), 69–72. [in Ukrainian].

Danby, S. G. (2104) A new perspective on histamine in atopic dermatitis. Br. J. Dermatol., 171(4), 688. doi: 10.1111/bjd.13315

Kogan, B. G., & Verba, Ye. A. (2013). Novye evropeyskie podkhody v terapii rezistentnykh form allergodermatozov [New European approaches in treatment of resistant forms of allergic dermatoses]. Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii, 1(48), 137–143. [in Russian].

Carlsten, C., Dimich-Ward, H., Ferguson, A., Watson, W., Rousseau, R., Dybuncio, A., et al. (2013) Atopic dermatitis in a high-risk cohort: natural history, associated allergic outcomes, and risk factors. Ann. Allergy Asthma Immunol, 110(1), 24–28. doi: 10.1016/j.anai.2012.10.005

Tsakok, T., McKeever, T. M., Yeo, L., & Flohr, C. (2013) Does early life exposure to antibiotics increase the risk of eczema? A systematic review. Br. J. Dermatol., 169(5), 983–91. doi: 10.1111/bjd.12476

Bolotnaya, L. A., & Osipenko, T. S. (2014). Korrekciya disbioza u bol'nykh atopicheskim dermatitom [Correction of dysbiosis in patients with atopic dermatitis]. Dermatolohiia ta venerolohiia, 3, 67–68. [in Russian].

Reznichenko, Yu. G., Pantyushenko, L. I., & Reznichenko, N. Yu. (2013). Khronichni alerhichni zakhvoriuvannia shkiry: uiavlennia pro etiopatohenez ta pidkhody do vyboru optymalnoi terapii [Chronic allergic skin diseases: modern approaches to etiopathogenesis and optimal treatment]. Dermatovenerolohiia, kosmetolohiia, seksopatolohiia, 1–4, 247–454. [in Ukrainian].

Kaliuzhna, L. D., Litus, O. I., Oshyvalova, O. O., & Bardova, K. O. (2013). Osoblyvosti klinichnoho perebihu ta udoskonalennia diahnostyky i likuvannia psoriazu [Peculiarities of clinical course and improvement of diagnostics and treatment for psoriasis: methodical recommendations]. Kyiv. [in Ukrainian].


How to Cite

Reznichenko, N. Y. (2019). Comparative study of the effectiveness of antihistamine preparations in the treatment of patients with atopic dermatitis. Zaporozhye Medical Journal, (5).



Original research