The level of serum and vaginal immunoglobulins in experimental vaginitis and its pharmacological correction

Authors

  • O. V. Dolzhykova National University of Pharmacy, Kharkiv, Ukraine,
  • R. F. Yeromenko National University of Pharmacy, Kharkiv, Ukraine,
  • V. V. Kozar National University of Pharmacy, Kharkiv, Ukraine,
  • O. M. Lytvynova National University of Pharmacy, Kharkiv, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2020.2.200585

Keywords:

vaginitis, immunoglobulins A, M, G, secretory Ig A, vaginal washings, suppositories Melanizol and Klimedeks

Abstract

 

The problem of searching effective drugs for the treatment of infectious and inflammatory diseases of the female genital tract, which are accompanied by changes in the immune system, remains relevant.

The purpose of the study to investigate the level of immunoglobulins A, M, G and secretory immunoglobulin A in blood serum and vaginal washings in experimental vaginitis and in conditions of using new vaginal suppositories Melanizol and Klimedeks.

Materials and methods. The study was conducted using non-linear sexually mature female rats weighing 190 ±10 g. Vaginitis was modeled by a single intravaginal application of an irritant, presented by the mixture of terebenthine oil with dimethyl sulfoxide. We studied the effect of the vaginal suppositories Melanizol and Klimedeks and the reference drugs: suppositories Gravagin, vaginal tablets Micogynax and Suppositories with Hippophaes oleum. At the end of the 8-day experimental period, the concentration of immunoglobulins IgA, IgM, IgG and secretory immunoglobulin A (sIgA) in blood serum and vaginal washings were studied.

Results. The absence of significant changes in the concentration of Ig A, M, G in the serum of rats with experimental vaginitis and the tendency to increase in levels of Ig A, M, G in vaginal washings compared with indicators in intact animals. The serum and vaginal sIg A values were 2.5 and 1.4 times decreased in rats with vaginitis, respectively, compared with the intact controls. All studied drugs increased the concentration of the secretory immunoglobulin, and suppositories Klimedeks had a more significant effect.

Conclusions. Experimental vaginitis is characterized by a tendency to an increase in the concentration of Ig A, M, G in the vaginal washings and a significant decrease in the levels of serum and vaginal sIg A. The studied suppositories Melanizole and Klimedeks are as effective as Gravagin, Micogynax and Suppositories with Hippophaes oleum.

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How to Cite

1.
Dolzhykova OV, Yeromenko RF, Kozar VV, Lytvynova OM. The level of serum and vaginal immunoglobulins in experimental vaginitis and its pharmacological correction. Zaporozhye Medical Journal [Internet]. 2020Apr.13 [cited 2024Jul.17];22(2). Available from: http://zmj.zsmu.edu.ua/article/view/200585

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Original research