Clinical and psychopathological features of first-episode bipolar affective disorder

Authors

DOI:

https://doi.org/10.14739/2310-1210.2020.4.208392

Keywords:

bipolar affective disorder, primary episode, clinical and psychopathological phenomenology

Abstract

The article analyzes the clinical and gender features of clinical and psychopathological phenomenology of the first-episode bipolar affective disorder (BAD).

The aim of the work was to study the features of the psychopathological phenomenology of the first-episode of BAD in the context of the clinical variant and taking into account the gender factor.

Materials and methods. In total, 65 men and 88 women with first-episode BAD were clinically examined using the Symptom Check List-90-Revised Psychopathological Symptom Expression Questionnaire.

Results. In the depressed type of the first-episode BAD in men, the levels of depression were significantly higher – 2.80 ± 0.48 points versus 2.61 ± 0.49 points (P = 0.044); interpersonal sensitivity – 1.39 ± 0,31 points versus 1.28 ± 0.28 points (P = 0.037), and in women – insignificantly higher levels of somatization, obsessive compulsive symptoms, anxiety, hostility, phobic anxiety. In patients with a manic episode, the level of somatization, hostility and psychosis was insignificantly higher in men, and obsessive-compulsive symptoms, phobic anxiety – in women. In the mixed episode, men had insignificantly higher indicators of obsessive-compulsive symptoms, interpersonal sensitivity, phobic anxiety, paranoid symptoms, and women - somatization, depression and anxiety.

Significantly stronger association between psychopathological symptoms severity and the clinical variant of BAD was revealed, in particular, significantly higher levels of all psychopathological symptoms severity, with the exception of paranoid, as compared to patients with depressive and manic episodes; comparing patients with depressive and mixed episodes, there were differences in interpersonal sensitivity (P = 0.000), depression (P = 0.000) in men, obsessive-compulsive symptomatology (P = 0.012), interpersonal sensitivity (P = 0.000), depression (P = 0.000) in women, and obsessive-compulsive symptomatic (P = 0.021), interpersonal sensitivity (P = 0.000), depression (P = 0.000) in all patients. The comparison between groups with manic and mixed episodes found differences in somatization (P = 0.002), obsessive compulsive symptoms (P = 0.007), depression (P = 0.001), anxiety (P = 0.001), hostility (P = 0.012) in men (P = 0.004), somatization (P = 0.003), depression (P = 0.004), anxiety (P = 0.004), hostility (P = 0.011), psychosis (P = 0.019) in women, somatization (P = 0.000), obsessive-compulsive symptoms (P = 0.003), interpersonal sensitivity (P = 0.017), depression (P = 0.000), anxiety (P = 0.000), hostility (P = 0.000), psychosis (P = 0.006) in all subjects.

Conclusions. The data obtained suggest a pivotal role of psychopathological symptoms severity in first- episode BAD and its clinical variant while the gender factor plays a secondary one.

References

Rowland, T. A., & Marwaha, S. (2018). Epidemiology and risk factors for bipolar disorder. Therapeutic Advances in Psychopharmacology, 8(9), 251-269. https://doi.org/10.1177/2045125318769235

Patel, R., Shetty, H., Jackson, R., Broadbent, M., Stewart, R., Boydell, J., McGuire, P., & Taylor, M. (2015). Delays before Diagnosis and Initiation of Treatment in Patients Presenting to Mental Health Services with Bipolar Disorder. PLOS ONE, 10(5), Article e0126530. https://doi.org/10.1371/journal.pone.0126530

Hayes, J. F., Miles, J., Walters, K., King, M., & Osborn, D. P. (2015). A systematic review and meta-analysis of premature mortality in bipolar affective disorder. Acta psychiatrica Scandinavica, 131(6), 417-425. https://doi.org/10.1111/acps.12408

Marwaha, S., Durrani, A., & Singh, S. (2013). Employment outcomes in people with bipolar disorder: a systematic review. Acta psychiatrica Scandinavica, 128(3), 179-193. https://doi.org/10.1111/acps.12087

Trisha, C., Golnoush, A., Jan-Marie, K., Torres, I. J., & Yatham, L. N. (2018). Cognitive functioning in first episode bipolar I disorder patients with and without history of psychosis. Journal of affective disorders, 227, 109-116. https://doi.org/10.1016/j.jad.2017.10.003

Kessing, L. V., & Miskowiak, K. (2018). Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype? - A Perspective Paper. Frontiers in psychiatry, 9, Article 490. https://doi.org/10.3389/fpsyt.2018.00490

Maruta, N. A. (2011). Diagnostika bipolyarnogo affektivnogo rasstroistva [Diagnostic of bipolar affective disorder]. NeiroNews, (4), 57-60. https://neuronews.com.ua/ru/issue-article-484/Diagnostika-bipolyarnogo-affektivnogo-rasstroystva#gsc.tab=0 [in Russian].

Baldessarini, R. J., Tondo, L., & Visioli, C. (2014). First-episode types in bipolar disorder: predictive associations with later illness. Acta psychiatrica Scandinavica, 129(5), 383-392. https://doi.org/10.1111/acps.12204

Faedda, G. L., Serra, G., Marangoni, C., Salvatore, P., Sani, G., Vázquez, G. H., Tondo, L., Girardi, P., Baldessarini, R. J., & Koukopoulos, A. (2014). Clinical risk factors for bipolar disorders: a systematic review of prospective studies. Journal of affective disorders, 168, 314-321. https://doi.org/10.1016/j.jad.2014.07.013

Salvatore, P., Baldessarini, R. J., Khalsa, H. M., Vázquez, G., Perez, J., Faedda, G. L., Amore, M., Maggini, C., & Tohen, M. (2014). Antecedents of manic versus other first psychotic episodes in 263 bipolar I disorder patients. Acta psychiatrica Scandinavica, 129(4), 275-285. https://doi.org/10.1111/acps.12170

Gautam, S., Jain, A., Gautam, M., Gautam, A., & Jagawat, T. (2019). Clinical Practice Guidelines for Bipolar Affective Disorder (BPAD) in Children and Adolescents. Indian journal of psychiatry, 61(Suppl. 2), 294-305. https://doi.org/10.4103/psychiatry.IndianJPsychiatry_570_18

Tarabrina, N. V. (2001). Praktikum po psikhologii posttravmaticheskogo stressa [Workshop on the psychology of posttraumatic stress]. Piter. [in Russian].

Kerner, B. (2014). Genetics of bipolar disorder. The application of clinical genetics, 7, 33-42. https://doi.org/10.2147/TACG.S39297

Patel, R. S., Virani, S., Saeed, H., Nimmagadda, S., Talukdar, J., & Youssef, N. A. (2018). Gender Differences and Comorbidities in U.S. Adults with Bipolar Disorder. Brain sciences, 8(9), Article 168. https://doi.org/10.3390/brainsci8090168

Rios, A. C., Noto, M. N., Rizzo, L. B., Mansur, R., Martins, F. E., Jr, Grassi-Oliveira, R., Correll, C. U., & Brietzke, E. (2015). Early stages of bipolar disorder: characterization and strategies for early intervention. Revista brasileira de psiquiatria, 37(4), 343-349. https://doi.org/10.1590/1516-4446-2014-1620

How to Cite

1.
Mysula YI, Venher OP, Sydliaruk NI. Clinical and psychopathological features of first-episode bipolar affective disorder. Zaporozhye Medical Journal [Internet]. 2020Jul.22 [cited 2024Nov.23];22(4). Available from: http://zmj.zsmu.edu.ua/article/view/208392

Issue

Section

Original research