Endotheliumprotectiv and antihypoxic properties of quercetin in elderly patients with metabolic syndrome

Authors

  • O. V. Korkushko SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine
  • I. A. Antoniuk-Shcheglova SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine
  • S. S. Naskalova SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine
  • O. V. Bondarenko SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine
  • O. M. Hryb SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine
  • V. B. Shatylo SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine
  • N. M. Koshel SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine

DOI:

https://doi.org/10.14739/2310-1210.2021.2.228707

Keywords:

metabolic syndrome, elderly age, quercetin, functional state of the endothelium, hypoxia

Abstract

Aim: To investigate the effectiveness of course quercetin in improving functional state of the microvascular endothelium and to determine the possibility of using quercetin to increase body resistance to hypoxia in the elderly.

Materials and methods. The effectiveness of quercetin in improving the functional state of the endothelium and increasing body resistance to hypoxia was studied in 110 elderly patients with metabolic syndrome, who were divided equally into the main and control groups. Patients in the main group received quercetin at a daily dose of 240 mg for 3 months, and patients in the control group received placebo for the same period. Before and after treatment, the microvascular endothelial function was studied by laser Doppler flowmetry using the post-occlusive hyperemia test. Acute hypoxic test was performed under isocapnicnormobaric hypoxia, during which the followings were recorded: blood saturation (SpO2), heart rate and diastolic blood pressure (BP).

Results. In the group of patients receiving quercetin, there was an improvement in blood flow to the skin, as evidenced by a statistically significant increase in the maximum volumetric rate of cutaneous blood flow and the duration of the recovery period of OSHSK to baseline in the post-occlusive hyperaemia.

The course of quercetin also led to a less significant decrease in SpO2 during hypoxic test and to a decrease in the absolute values of systolic and diastolic blood pressure, while reducing an increase of the systolic blood pressure on the 20th min of the hypoxic test.

Conclusions. In elderly patients with metabolic syndrome (within a 3 month course) the use of quercetin has improved the microvascular endothelium functional status and increased the resistance to hypoxia.

Author Biographies

O. V. Korkushko, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

MD, PhD, DSc, Professor, Academician of the NAMS of Ukraine

I. A. Antoniuk-Shcheglova, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

MD, PhD, DSc, Chief Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

S. S. Naskalova, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

MD, PhD, Senior Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

O. V. Bondarenko, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

MD, PhD, Senior Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

O. M. Hryb, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

MD, PhD, Doctor of the Department of Clinical Physiology and Pathology of Internal Organs

V. B. Shatylo, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

MD, PhD, DSc, Professor, Deputy Director of the SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”

N. M. Koshel, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

PhD, Leading Researcher, Laboratory for Mathematical Modeling of Aging Processes

References

Flammer, A. J., Anderson, T., Celermajer, D. S., Creager, M. A., Deanfield, J., Ganz, P., Hamburg, N. M., Lüscher, T. F., Shechter, M., Taddei, S., Vita, J. A., & Lerman, A. (2012). The Assessment of Endothelial Function: From Research Into Clinical Practice. Circulation, 126(6), 753-767. https://doi.org/10.1161/CIRCULATIONAHA.112.093245

Matsuzawa, Y., & Lerman, A. (2014). Endothelial dysfunction and coronary artery disease: assessment, prognosis, and treatment. Coronary Artery Disease, 25(8), 713-724. https://doi.org/10.1097/MCA.0000000000000178

Pi, X., Xie, L., & Patterson, C. (2018). Emerging Roles of Vascular Endothelium in Metabolic Homeostasis. Circulation Research, 123(4), 477-494. https://doi.org/10.1161/CIRCRESAHA.118.313237

Babik, B., Peták, F., Agócs, S., Blaskovics, I., Alács, E., Bodó, K., & Südy, R. (2018). Diabetes mellitus: endotheldiszfunkció és haemostasiselváltozások. Orvosi Hetilap, 159(33), 1335-1345. https://doi.org/10.1556/650.2018.31130

Zharinova, V. Y., Bodretskaya, L., Duzhak, G., Samots, S. I., Shapovalenko, I., & Voinarovskaya, G. (2018). Functional State of Endothelium in Aging. Gerontology & Geriatrics Studies, 2(5), 191-194. https://doi.org/10.31031/GGS.2018.02.000548

Korkushko, O. V., & Ivanov, L. A. (1980). Gipoksiya i starenie [Hypoxia and aging]. Naukova dumka. [in Russian].

Wong, B. W., Marsch, E., Treps, L., Baes, M., & Carmeliet, P. (2017). Endothelial cell metabolism in health and disease: impact of hypoxia. The EMBO Journal, 36(15), 2187-2203. https://doi.org/10.15252/embj.201696150

Mykhailovska, N. S., & Oliinyk, T. V. (2016). Dynamika rivniv imunozapalnykh markeriv na tli terapii kvertsetynom u khvorykh na ishemichnu khvorobu sertsia, asotsiiovanu z hipotyreozom [Dynamics of immunoinflammatory markers level on the background of quercetin therapy in patients with ischemic heart disease associated with hypothyroidism]. ScienceRise, 1(3), 32-36. https://doi.org/10.15587/2313-8416.2016.59038 [in Ukrainian].

Parshykov, O. V., Utko, N. O., & Gorban, E. M. (2019). Vplyv kvertsetynu (Kvertynu) na vidnovlennia NO-zalezhnykh reaktsii sudyn za uchastiu endoteliiu ta peryvaskuliarnoi zhyrovoi tkanyny v shchuriv pislia renthenivskoho oprominennia [Effect of quercetin (Quertin) on NO-dependent reactions of rat blood vessels with participation of endothelium and perivascular adipose tissue after X-ray exposure]. Farmakolohiia ta likarska toksykolohiia, 13(4), 277-285. https://doi.org/10.33250/13.04.277 [in Ukrainian].

Lozano, O., Lázaro-Alfaro, A., Silva-Platas, C., Oropeza-Almazán, Y., Torres-Quintanilla, A., Bernal-Ramírez, J., Alves-Figueiredo, H., & García-Rivas, G. (2019). Nanoencapsulated Quercetin Improves Cardioprotection during Hypoxia-Reoxygenation Injury through Preservation of Mitochondrial Function. Oxidative Medicine and Cellular Longevity, 2019, Article 7683051. https://doi.org/10.1155/2019/7683051

Chiş, I. C., Baltaru, D., Dumitrovici, A., Coseriu, A., Radu, B. C., Moldovan, R., & Mureşan, A. (2018). Protective effects of quercetin from oxidative/nitrosative stress under intermittent hypobaric hypoxia exposure in the rat's heart. Physiology International, 105(3), 233-246. https://doi.org/10.1556/2060.105.2018.3.23

Barnes, B. J., Adrover, J. M., Baxter-Stoltzfus, A., Borczuk, A., Cools-Lartigue, J., Crawford, J. M., Daßler-Plenker, J., Guerci, P., Huynh, C., Knight, J. S., Loda, M., Looney, M. R., McAllister, F., Rayes, R., Renaud, S., Rousseau, S., Salvatore, S., Schwartz, R. E., Spicer, J. D., Yost, C. C., … Egeblad, M. (2020). Targeting potential drivers of COVID-19: Neutrophil extracellular traps. Journal of Experimental Medicine, 217(6), Article e20200652. https://doi.org/10.1084/jem.20200652

Wang, L., Chen, J., Wang, B., Wu, D., Li, H., Lu, H., Wu, H., & Chai, Y. (2014). Protective effect of quercetin on lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammatory cell influx. Experimental Biology and Medicine, 239(12), 1653-1662. https://doi.org/10.1177/1535370214537743

Mahase, E. (2020). Covid-19: what treatments are being investigated? BMJ, 368, Article m1252. https://doi.org/10.1136/bmj.m1252

Gilmore, T. D., & Herscovitch, M. (2006). Inhibitors of NF-κB signaling: 785 and counting. Oncogene, 25(51), 6887-6899. https://doi.org/10.1038/sj.onc.1209982

Weng, Z., Zhang, B., Asadi, S., Sismanopoulos, N., Butcher, A., Fu, X., Katsarou-Katsari, A., Antoniou, C., & Theoharides, T. C. (2012). Quercetin Is More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans. PLOS ONE, 7(3), Article e33805. https://doi.org/10.1371/journal.pone.0033805

Iskender, H., Dokumacioglu, E., Sen, T. M., Ince, I., Kanbay, Y., & Saral, S. (2017). The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model. Biomedicine & Pharmacotherapy, 90, 500-508. https://doi.org/10.1016/j.biopha.2017.03.102

Mitchenko, O. I., Korpachev, V. V., Bahrii, A. E., Zviahina, T. V., Koval, S. M., Kovalova, O. M., Lutai, M. I., Mankovskyi, B. M., Pankiv, V. I., Svishchenko, Ye. P., Sirenko, Yu. M., Sokolova, L. K., & Talaieva, T. V. (2009). Diahnostyka i likuvannia metabolichnoho syndromu, tsukrovoho diabetu, prediabetu i sertsevo-sudynnykh zakhvoriuvan [Diagnosis and treatment of metabolic syndrome, diabetes, prediabetes and cardiovascular disease]. Kyiv. http://strazhesko.org.ua/upload/2014/02/20/metodichka_a5_-n1402-_ua.pdf [in Ukrainian].

Zeka, K., Ruparelia, K., Arroo, R., Budriesi, R., & Micucci, M. (2017). Flavonoids and Their Metabolites: Prevention in Cardiovascular Diseases and Diabetes. Diseases, 5(3), Article 19. https://doi.org/10.3390/diseases5030019

Sánchez, M., Galisteo, M., Vera, R., Villar, I. C., Zarzuelo, A., Tamargo, J., Pérez-Vizcaíno, F., & Duarte, J. (2006). Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. Journal of Hypertension, 24(1), 75-84. https://doi.org/10.1097/01.hjh.0000198029.22472.d9

Patel, R. V., Mistry, B. M., Shinde, S. K., Syed, R., Singh, V., & Shin, H.-S. (2018). Therapeutic potential of quercetin as a cardiovascular agent. European Journal of Medicinal Chemistry, 155, 889-904. https://doi.org/10.1016/j.ejmech.2018.06.053

Varga, Z., Flammer, A. J., Steiger, P., Haberecker, M., Andermatt, R., Zinkernagel, A. S., Mehra, M. R., Schuepbach, R. A., Ruschitzka, F., & Moch, H. (2020). Endothelial cell infection and endotheliitis in COVID-19. The Lancet, 395(10234), 1417-1418. https://doi.org/10.1016/S0140-6736(20)30937-5

Korkushko, O. V., Naskalova, S. S., Antonyuk-Shcheglova, I. A., Duzhak, G. V., Bondarenko, O. V., Grib, O. M., & Shatilo, V. B. (2019). Vplyv kvertsetynu na reolohichni vlastyvosti krovi v patsiientiv pokhyloho viku z metabolichnym syndromom [Quercetine influence on the resological properties of blood for elderly patients with metabolic syndrome]. Ukrainskyi kardiolohichnyi zhurnal, 26(3), 71-77. http://doi.org/10.31928/1608-635X-2019.3.7177 [in Ukrainian].

Korkushko, O. V., Shatilo, V. B., Antoniuk-Shcheglova, I. A., Naskalova, S. S., Bondarenko, O. V., & Grib, O. M. (2020). Vplyv kvertsetynu na pokaznyky vuhlevodnoho ta lipidnoho obminu u liudei pokhyloho viku z metabolichnym syndromom [Effect of quercetin on the indicators of carbohydrate and lipid metabolism in elderly people with metabolic syndrome]. Problemy endokrynnoi patolohii, (1), 36-40. https://doi.org/10.21856/j-PEP.2020.1.05 [in Ukrainian].

Published

2021-04-16

How to Cite

1.
Korkushko OV, Antoniuk-Shcheglova IA, Naskalova SS, Bondarenko OV, Hryb OM, Shatylo VB, Koshel NM. Endotheliumprotectiv and antihypoxic properties of quercetin in elderly patients with metabolic syndrome. Zaporozhye Medical Journal [Internet]. 2021Apr.16 [cited 2024Nov.24];23(2):195-201. Available from: http://zmj.zsmu.edu.ua/article/view/228707

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Section

Original research