Endotheliumprotectiv and antihypoxic properties of quercetin in elderly patients with metabolic syndrome

Authors

  • O. V. Korkushko SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine
  • I. A. Antoniuk-Shcheglova SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine
  • S. S. Naskalova SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine
  • O. V. Bondarenko SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine
  • O. M. Hryb SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine
  • V. B. Shatylo SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine
  • N. M. Koshel SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine

DOI:

https://doi.org/10.14739/2310-1210.2021.2.228707

Keywords:

metabolic syndrome, elderly age, quercetin, functional state of the endothelium, hypoxia

Abstract

Aim: To investigate the effectiveness of course quercetin in improving functional state of the microvascular endothelium and to determine the possibility of using quercetin to increase body resistance to hypoxia in the elderly.

Materials and methods. The effectiveness of quercetin in improving the functional state of the endothelium and increasing body resistance to hypoxia was studied in 110 elderly patients with metabolic syndrome, who were divided equally into the main and control groups. Patients in the main group received quercetin at a daily dose of 240 mg for 3 months, and patients in the control group received placebo for the same period. Before and after treatment, the microvascular endothelial function was studied by laser Doppler flowmetry using the post-occlusive hyperemia test. Acute hypoxic test was performed under isocapnicnormobaric hypoxia, during which the followings were recorded: blood saturation (SpO2), heart rate and diastolic blood pressure (BP).

Results. In the group of patients receiving quercetin, there was an improvement in blood flow to the skin, as evidenced by a statistically significant increase in the maximum volumetric rate of cutaneous blood flow and the duration of the recovery period of OSHSK to baseline in the post-occlusive hyperaemia.

The course of quercetin also led to a less significant decrease in SpO2 during hypoxic test and to a decrease in the absolute values of systolic and diastolic blood pressure, while reducing an increase of the systolic blood pressure on the 20th min of the hypoxic test.

Conclusions. In elderly patients with metabolic syndrome (within a 3 month course) the use of quercetin has improved the microvascular endothelium functional status and increased the resistance to hypoxia.

Author Biographies

O. V. Korkushko, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

MD, PhD, DSc, Professor, Academician of the NAMS of Ukraine

I. A. Antoniuk-Shcheglova, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

MD, PhD, DSc, Chief Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

S. S. Naskalova, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

MD, PhD, Senior Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

O. V. Bondarenko, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

MD, PhD, Senior Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

O. M. Hryb, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

MD, PhD, Doctor of the Department of Clinical Physiology and Pathology of Internal Organs

V. B. Shatylo, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

MD, PhD, DSc, Professor, Deputy Director of the SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”

N. M. Koshel, SI “D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv

PhD, Leading Researcher, Laboratory for Mathematical Modeling of Aging Processes

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Published

2021-04-16

How to Cite

1.
Korkushko OV, Antoniuk-Shcheglova IA, Naskalova SS, Bondarenko OV, Hryb OM, Shatylo VB, Koshel NM. Endotheliumprotectiv and antihypoxic properties of quercetin in elderly patients with metabolic syndrome. Zaporozhye Medical Journal [Internet]. 2021Apr.16 [cited 2024Jun.18];23(2):195-201. Available from: http://zmj.zsmu.edu.ua/article/view/228707

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Section

Original research