New approaches to reduce ulcerogenity of nonsteroidal anti-inflammatory drugs: achievements, unsolved issues and ways to optimize

Authors

  • F. V. Hladkykh
  • N. H. Stepaniuk

DOI:

https://doi.org/10.14739/2310-1210.2014.2.25437

Keywords:

NSAID-induced gastropathy, Ibuprofen, Vinboron, Quercetin

Abstract

Analysis of the domestic and foreign literature sources devoted to the study of pathogenetic mechanisms of gastropathy caused by non-steroidal anti-inflammatory drugs was done. Current approaches of prevention and treatment of NSAID-induced gastropathy were lined. The appropriateness of drugs with polytropic pharmacological properties (Quercetin, Vinboron and Tiotriazolin) to eliminate the side effects of NSAIDs, including ultserogenesis was discusses.

References

Alekseenko S. A., & Tymoshyn, S. S., & Bolonyaeva, N. A. (2004). Sovremennye vozmozhnosty y perspektyvy profylaktyky NPVP-hastropatyy [Modern possibilities and prospects for prevention of NSAID–gastropathy]. Klynycheskye perspektyvy hastroenterolohyy, hepatolohyy, 2, 32-34 [in Russian].

Akhmedov, V. A. (2007). Hastropatyya, obuslovlennaya nesteroydnymy protyvovospalytel'nymy preparatamy: ot ponymanyya mekhanyzmov razvytyya k razrabotke startehyy lechenyya y profylaktyky [Hastropathy due to nonsteroidal anti-inflammatory drugs: from understanding the mechanisms of development to the development of treatment and prevention startegii]. Terapevtycheskyy arkhyv, 79/2, 81-85 [in Russian].

Bukhtiarova, T. A., & Omel'yanenko, Z. P., & Yadlovs'kyy, O. Ye. (2007) Shlyakhy korektsiyi pobichnoyi diyi nesteroyidnykh protyzapal'nykh zasobiv [By correcting side-effects of NSAIDs]. Farmatsevtychnyy zhurnal, 1, 38-44 [in Ukrainian].

Vakhrushev, Ya. M., & Zahrebyna, E. A. (2012). Enteropatyya, yndutsyrovannaya nesteroydnymy protyvovospalytel'nymy preparatamy (patohenez, dyahnostyka, lechenye) [Induced by nonsteroidal anti-inflammatory drugs ( pathogenesis, diagnosis, treatment)]. Terapevtycheskyy arkhyv, 84/5, 74-79 [in Russian].

Voloshyn N. A., & Vyzyr, V. A., & Voloshyna, Y. N. (2008). Tyotryazolyn, tyotsetam, tyodaron v praktyke vracha [Thiotriazolin, tiocetam, tiodaron in the practice]. Zaporozh'e: ZSMU [in Russian].

Happe. N.A. (2013). Effektyvnost' y bezopasnost' ybuprofena pry lykhoradke u detey [The efficacy and safety of ibuprofen for fever in children]. Ukrayins'kyy medychnyy chasopys, 3, 115-117[in Russian].

Hlazova, A. V., & Poteshkyna, N. H. (2012). Hastroprotektsyya u patsyentov, poluchayushchykh nesteroydnye protyvovospalytel'nye preparaty y antytrombotycheskuyu terapyyu [Gastroprotektsiya in patients receiving non-steroidal anti-inflammatory drugs and antithrombotic therapy]. Rossyyskyy medytsynskyy zhurnal, 1, 46-50 [in Russian].

Ivanova, N. I., & Stepanyuk, H. I. (2000), Eksperymental'ne doslidzhennya spazmolitychnykh vlastyvostey vinboronu [Experimental study of antispasmodic properties of vinboron]. Fenikaberan (vinboron) i benzofurakayin: novi pidkhody do farmakoterapiyi zapal'nykh ta ishemichnykh protsesiv: Nauk.-prakt. konf. Vinnytsya: Tezys, 33-34 [in Ukrainian].

Karateev, A. E., & Nasonova, V.A. (2008). Razvytye y retsydyvyrovanye yazv zheludka y dvenadtsatyperstnoy kyshky u bol'nykh, prynymayushchykh nesteroydnye protyvovospalytel'nye preparaty: vlyyanye standartnykh faktorov ryska [Development and recurrence of gastric and duodenal ulcers in patients taking non-steroidal anti-inflammatory drugs : the effect of the standard risk factors]. Terapevtycheskyy arkhyv, 80/5, 62-66 [in Russian].

Karateev, A. E. (2013). Chto luchshe dlya profylaktyky NPVP-hastropatyy: koksyby yly kombynatsyya «tradytsyonnykh» NPVP y hastroprotektora? [What is better for the prevention of NSAID- gastropathy : coxibs or a combination of "traditional" NSAIDs and gastroprotectives]. RMZh Hastroeterolohyya, 13, 5-12[in Russian].

Katerenchuk, I. P. (2010). Pobichni efekty nesteroyidnykh protyzapal'nykh zasobiv ta yikh optymal'nyy vybir u praktytsi simeynoho likarya [Side effects of NSAIDs and their optimal choice in the practice of the family doctor]. Simeyna medytsyna, 1, 19-28 [in Ukrainian].

Kashuba, O. (2005). Otsinka pobichnoyi diyi okremykh nesteroyidnykh protyzapal'nykh zasobiv [Assessment of side effects of some NSAIDs]. Liky ukrayiny., 12, 101-105 [in Ukrainian].

Kutsenko, T. O. (2007). Eksperymental'ne obgruntuvannya vyboru korektoriv hastrotoksychnoyi diyi NPZZ [Experimental study selection correction hastrotoksychnoyi action of NSAIDs]. Liky 5/6, 75-79 [in Ukrainian].

Lapyna, T. L. (2009). Lechenye y profylaktyka hastropatyy, yndutsyrovannykh nesteroydnymy protyvovospalytel'nymy sredstvamy, v praktyke terapevta [Treatment and prevention of gastropathy induced by non-steroidal anti-inflammatory drugs, in practice, the therapist]. Rossyyskyy zhurnal hastroenterolohyy, hepatolohyy, koloproktolohyy, XIX/ 4, 13-18 [in Russian].

Maev, Y. V., & V'yuchnova, E. S., & Staseva, Y. V. (2004). Sravnytel'naya otsenka razlychnykh skhem terapyy hastropatyy, vyzvannykh nesteroydnymy protyvovospalytel'nymy preparatamy. [Comparative evaluation of different regimens of gastropathy caused by non-steroidal anti-inflammatory drugs]. Terapevtycheskyy arkhyv, 76/2, 27-30 [in Russian].

Mazur, & Y. A. Voloshyn, N. A., & Chekman, Y.S. (2005). Tyotryazolyn: farmakolohycheskye aspekty y klynycheskoe prymenenye [Thiotriazolin: pharmacological aspects and clinical application: monograph]. Zaporozh'e, 146 p.

Morozova, T. E., & Andrushyshyna, T. B., & Antypova, E. K. (2013). Ybuprofen: bezopasnost' y эffektyvnost' prymenenyya v shyrokoy klynycheskoy praktyke (obzor) [Ibuprofen: safety and efficacy in clinical practice (review)]. Terapevtycheskyy arkhyv. 85/3, 118-124 [in Russian].

Morokht, M. A., & Danova I. V., & Myslyvets, S. O. (2009) Farmakodynamika kvertsetynu ta yoho likars'kykh form [Pharmacodynamics of quercetin and its dosage forms]. Farmakolohiya ta likars'ka toksykolohiya, 6(13), 3-7 [in Ukrainian].

Orekhova, O. (2011) Kvertsetyn v famakoterapyy hastropatyy, svyazannykh s pryёmom NPVS [Quercetin in famakoterapii gastropathy associated with NSAID]. Provyzor, 19, 31-32 [in Russian].

Podpletnyaya, & E. A. Mamchur, V. Y. (2005) Mekhanyzmyy hastroduodenotoksychnosty nesteroydnykh protyvovospalytel'nykh sredstv [Mechanisms gastroduodenotoksichnosti NSAIDs]. Zhurnal Akademiyi medychnykh nauk Ukrayiny, 11/1, 47-62 [in Russian].

Savchenkova, L.V., & Fylatov, D.A., & Belousov, Y.P. (2008). Klynyecheskaya farmakolohyya tyotryazolyna [Klinical pharmacology Thiotriazoline]. Ukrayins'kyy medychnyy al'manakh, 11/3, 212-217 [in Russian].

Svintsyts'kyy, A. S., & Katerenchuk, & I. P., Yarmola, T. I. (2010). NPZZ-hastropatiyi: mynule, suchasne i s'ohodennya [NSAID gastropathy: Past, Present and Present]. Suchasni medychni tekhnolohiyi, 2, 95-100 [in Ukrainian].

Sposib otrymannya 2-fenil-3-karboksy-5-hidroksybenzofuranu [Method for 2-phenyl-3-carboxy-5-hidroksybenzofuranu]. Bezpal'ko, L. V., & Shalamay, A. S., & Frosynyuk, M. S., & Stepanyuk, H. I., & Stolyarchuk, O. O. Patent Ukrayiny na vynakhid 25260A MKV S 08 F 112/12. 30.10.1998r [in Ukrainian].

Stepanyuk, H. I., & Pentyuk, O.O., & Piskun, R.P. Vinboron – likars'kyy zasib z politropnymy farmakolohichnymy vlastyvostyamy [Vinboron – a drug with pharmacological properties polytropic: monohrafy]. Vinnytsya, Ukraine [in Ukrainian].

Tkach, S. M., Syzenko, A. K. (2012) Effektyvnost' ynhybytorov protonnoy pompy v profylaktyke y lechenyy NPVP-hastropatyy s pozytsyy dokazatel'noy medytsyny [Effectiveness of proton pump inhibitors in the prevention and treatment of NSAID gastropathy positions with evidence-based medicine]. Ukrayins'kyy terapevtychnyy zhurnal, 1, 93-102 [in Russian].

Ushkalova E. (2005). Effektyvnost' y bezopasnost lekarstvennykh form Ybuprofena dlya mestnoho prymenenyya [Efficacy and safety of ibuprofen dosage forms for topical use]. Vrach, 12, 63-66 [in Russian].

Tsymmerman, Ya. S., & Tsymmerman, Y. Ya. (2008). Hastroduodenal'nye эrozyvno-yazvennye povrezhdenyya, yndutsyrovannye pryemom nesteroydnykh protyvovospalytel'nykh preparatov [Gastroduodenal erosive and ulcerative lesions induced by nonsteroidal anti-inflammatory drugs]. Klynycheskaya medytsyna: Nauchno-praktycheskyy zhurnal, 2, 8-14 [in Russian].

Chornoivan N. H. (2009). Vplyv vinboronu na hastrotoksychnist' dyklofenaku v eksperymenti [Effect vinboronu on hastrotoksychnist diclofenac experiment]. Farmakolohiya ta likars'ka toksykolohiya, 8, 39-4. [in Ukrainian].

Chornoivan, N. H., & Bukhtiarova, T.A., & Shalamay A.S. (2011). Vplyv korvitynu na shlunkovyy krovotik ta utylizatsiyu kysnyu shlunkom [Effect on gastric blood flow Corvitin and oxygen utilization stomach]. Farmakolohiya ta likars'ka toksykolohiya, 3, 64-66 [in Ukrainian].

Yaremenko, O. V. (2013). Hastroyntestynal'naya y kardyovaskulyarnaya bezopasnost' nesteroydnykh protyvovospalytel'nykh preparatov: sovremenno sostoyanye voprosa [Gastrointestinal and Cardiovascular safety of non-steroidal anti-inflammatory drugs: the present state of]. Therapia, 3, 63-68 [in Russian].

How to Cite

1.
Hladkykh FV, Stepaniuk NH. New approaches to reduce ulcerogenity of nonsteroidal anti-inflammatory drugs: achievements, unsolved issues and ways to optimize. Zaporozhye Medical Journal [Internet]. 2014Jun.19 [cited 2024Nov.2];16(2). Available from: http://zmj.zsmu.edu.ua/article/view/25437