Change of the components of nonspecific protection of respiratory system in diabetes mellitus

Authors

  • O. A. Pivovarova Lugansk State Medical University,

DOI:

https://doi.org/10.14739/2310-1210.2014.3.25708

Keywords:

Diabetes Mellitus, Respiratory System, Innate Immunity

Abstract

Aim. System of nonspecific respiratory protection factors in diabetes is currently insufficiently studied.

Methods and results. 63 diabetic patients and 46 healthy individuals passed diagnostic bronchoscopy. Histological examination of the respiratory system in experimental diabetes mellitus have been done in 47 rats and 43 intact animals (male) line Wistar.

Conclusion. Mechanisms of nonspecific protection of the respiratory system in insulin deficiency, neutrophil activity and inhibition of the functional activity of epithelial cells and alveolar macrophages were established.

References

Wang, G., Jiang, X., & Bai, C. (2010). Analysis of Pulmonary Function in 298 Patients With Diabetes Mellitus. Chest, 138(4 Meeting Abstracts), 565A–565A. doi:10.1378/chest.10174.

Metso, T., Venge, P., Haahtela, T., Peterson, C. G. B., & Sevéus, L. (2002) Cell specifi c markers for eosinophils and neutrophils in sputum and bronchoalveolarlavage fluid of patients with respiratory conditions and healthy subjects. Thorax, 5(57), 449–451. doi:10.1136/thorax.57.5.449.

Berger, K. I., Reibman, J., Oppenheimer, B. W., Vlahos, I., Harrison, D., Goldring, R. M. (2013) Lessons from the world trade center disaster: airway disease presenting as restrictive dysfunction. Chest, 1(144), 249–257.

Zinovev, S. V. (2010) Rukovodstvo po morfologii kletok bronkhoalveolyarnogo lavazha [Guide to cell morphology bronchoalveolar lavage]. Blagoveshhensk: AGMA. [in Russian].

Cazzola, M., MacNee, W., Martinez, F. J., Rabe, K. F., Franciosi, L. G., Barnes, P. J., et al. (2008) COPD: Outcomes for COPD Pharmacological Trials: From Lung Function to Biomarkers. European respiratory journal, 2(31), 416–469. doi: 10.1183/09031936.00099306.

Armin, E. (2009) Rukovodstvo po bronkhoskopii [Introduction to Bronchoscopy]. New York: Cambridge University Press.

Holdberg, E. D., Baluda, V. P., & Barkagan, Z. S. (1980) Laboratornye metody issledovaniya sistemy gemostaza [Laboratory methods of the hemostatic system]. Tomsk: Nayka. [in Russian].

(1995) Morfologicheskie i citologicheskie issledovaniya v diagnostike bronkholegochnoj patologii [Morphological and cytological studies in the diagnosis of bronchopulmonary diseases]. Moscow: Meditsina. [in Russian].

Merkulov, G. А. (1969) Kurs patogistologicheskoj tekhnik [The course of pathohistological techniques]. Moscow: Meditsina. [in Russian].

Rebrova, O. Yu.(2006) Statisticheskij analiz medicinskich dannykh [Statistical analysis of medical data]. Moskow: MediaSfera. [in Russian].

How to Cite

1.
Pivovarova OA. Change of the components of nonspecific protection of respiratory system in diabetes mellitus. Zaporozhye Medical Journal [Internet]. 2014Jul.4 [cited 2024Nov.24];16(3). Available from: http://zmj.zsmu.edu.ua/article/view/25708

Issue

Section

Original research