Vascular calcification and plasma levels of osteopontin in patients with chronic kidney disease who are treated by program hemodyalisis
DOI:
https://doi.org/10.14739/2310-1210.2014.3.25986Keywords:
Сhronic Renal Insufficiency, Renal Dialysis, Vascular Calcification, OsteopontinAbstract
Aim. To examine vascular calcification and plasma levels of osteopontin in patients with chronic kidney disease who are treated by program hemodyalisis
Methods and results. 53 patients were treated by renal hemodialysis. In this population the prevalence of abdominal aortic calcification was established using X-ray radiography. In 20 of them multislice computer tomography was conducted. There was a positive correlation between vascular calcification and phosphate levels, phosphate - calcium product. Plasma level of osteopontin in hemodialysis patients was significantly higher than in patients with predialysis stages of chronic kidney disease.
Conclusion. Positive correlation between plasma levels of citokine and abdominal aortic calcification may indicate that osteopontin is a marker of vascular calcification in patients, who are treated by program hemodialysis.
References
Barreto, D. V., Lenglet, A., Liabeuf, S., Kretschmer, A., Barreto, F. C., & Nollet, A. (2011) Prognostic implication of plasma osteopontin levels in patients with chronic kidney disease. Nephron Clin Pract, 117(4), 363–372. doi: 10.1159/000321520.
Choi, S. T., Kim, J. H., Kang, E., Lee, S., Park, M., Park, Y., et al. (2008). Osteopontin might be involved in bone remodelling rather than in inflammation in ankylosing spondylitis. Rheumatology, 47(12), 1775–1779. doi: 10.1093/rheumatology/ken385.
Covic, A., Kanbay, M., Voroneanu, L., Turgut, F., Serban, D.N., Serban, I. L., & Goldsmith, D. J. (2010) Vascular calcification in chronic kidney disease. Clin Sci (Lond), 119, 111–121. doi: 10.1042/CS20090631.
Coen, G., Gallucci, M. T., Balducci, A., Pierantozzi, A., Mantella, D., Manni, M., et al. (2007). Are PTH serum levels predictive of coronary calcifications in haemodialysis patients?. Nephrology Dialysis Transplantation, 22(11), 3262–3267. doi: 10.1093/ndt/gtm370.
Glynn, L. G., Glynn, D. R., Newell, J., Hinde, J., Buckley, B., & Murphy, A. W. (2007) Cronic kidney disease and mortality and morbidity among patients with established cardiovascular diseasе: a West of Ireland communiti-based cohort study. Nephrol. Dial. Transplant, 22(9), 2586–2594.
Grau, J. B., Acker, M. A., Bavaria, J. E., Field, B. C., Branchetti, E., Seefried, W. F., et al. (2012). Analysis of Osteopontin Levels for the Identification of Asymptomatic Patients With Calcific Aortic Valve Disease. The Annals of Thoracic Surgery, 93(1), 79–86.
Sainger, R., Grau, J. B., Poggio, P., Branchetti, E., Bavaria, J. E., Gorman, J. H., et al. (2012). Dephosphorylation of circulating human osteopontin correlates with severe valvular calcification in patients with calcific aortic valve disease. Biomarkers, 17(2), 111–118. doi: 10.3109/1354750X.2011.642407.
Fatherazi, S., Matsa-Dunn, D., Foster, B. L., Rutherford, R. B., Somerman, M. J., & Presland, R. B. (2009). Phosphate Regulates Osteopontin Gene Transcription. Journal of Dental Research, 88(1), 39–44. doi: 10.1177/0022034508328072.
Fujisawa, R., & Tamura, M. (2012) Acidic bone matrix proteins and their roles in calcification. Front Biosci., 1(17), 1891–1903.
Kalpakian, M. A., & Mehrotra, R. (2007). Vascular Calcification and Disordered Mineral Metabolism in Dialysis Patients. Seminars in Dialysis, 20(2), 139–143. doi:10.1111/j.1525-139X.2007.00261.x.
Karakan, S., Sezer, S., Acar, F., & Haberal, M. (2011). Circulating Levels of Osteopontin Are Related With Calcification Parameters in Patients With Renal Transplantations. Transplantation Proceedings, 43(2), 562–564. doi: 10.1016/j.transproceed.2011.01.026
(2009) KDIGO. Clinical Practice Guideline for the Diagnosis, Evaluation, Prevention, and Treatment of CKD-MBD. Kidney Int., 76(113), 1–130.
Noordzij, M., Krediet, R. T., Engelsman, L. F., Cranenburg, E. M., Korevaar, J. C., Schurgers, L. J., et al. (2011). Progression of aortic calcification is associated with disorders of mineral metabolism and mortality in chronic dialysis patients. Nephrology Dialysis Transplantation, 26(5), 1662–1669. doi: 10.1093/ndt/gfq582.
Lorenzen, J., Krämer, R., Kliem, V., Bode-Boeger, S. M., Veldink, H., Haller, H., et al. (2010). Circulating levels of osteopontin are closely related to glomerular filtration rate and cardiovascular risk markers in patients with chronic kidney disease. European Journal of Clinical Investigation, 40(4), 294–300. doi: 10.1111/j.1365-2362.2010.02271.x.
Uaesoontrachoon, K., Yoo, H., Tudor, E. M., Pike, R. N., Mackie, E. J., & Pagel, C. N. (2008). Osteopontin and skeletal muscle myoblasts: Association with muscle regeneration and regulation of myoblast function in vitro. The International Journal of Biochemistry & Cell Biology, 40(10), 2303–2314. doi: 10.1016/j.biocel.2008.03.020.
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