Pharmacogenic and neurologic components of residual condition in schizophrenia
DOI:
https://doi.org/10.14739/2310-1210.2022.6.259924Keywords:
residual schizophrenia, neuroleptic, comorbidity, organic pathology, positive and negative symptoms, correlation analysisAbstract
Aim. To systematize neuroleptic-induced and neurologic components of residual condition in schizophrenia.
Materials and methods. 100 patients of Communal Non-Profit Enterprise “Regional Clinical Institution for the Provision of Psychiatric Care” of Zaporizhzhia Regional Council with diagnosis of recurrent schizophrenia (ICD-10: F20.5) were examined.
Results. The study has found correlations between pharmacotherapy and cerebrovascular pathology with positive and negative symptoms of residual schizophrenia. Noticeable positive correlations were established between specific antipsychotic prescriptions and positive negative schizophrenia symptoms, while only minor correlations with negative symptoms were found.
Analysis of cerebrovascular pathology with positive and negative symptoms showed that most noticeable positive correlations were anterior area stroke with hallucinations.
Overall dominance of negative correlations over positive ones showed possible trend of “forced normalization” caused by cerebrovascular pathology of schizophrenia manifestations in recurrent condition, which was, however, also minor.
Conclusions. The study has found correlations between pharmacotherapy and cerebrovascular pathology with positive and negative symptoms of residual schizophrenia. The concept of “antipsychotic course experience” was introduced.
References
Andreasen, N. C., Flaum, M., & Arndt, S. (1992). The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Archives of general psychiatry, 49(8), 615-623. https://doi.org/10.1001/archpsyc.1992.01820080023004
Arango, C., Kirkpatrick, B., & Buchanan, R. W. (2000). Neurological signs and the heterogeneity of schizophrenia. The American journal of psychiatry, 157(4), 560-565. https://doi.org/10.1176/appi.ajp.157.4.560
Brown, K. W., & White, T. (1991). The association among negative symptoms, movement disorders, and frontal lobe psychological deficits in schizophrenic patients. Biological psychiatry, 30(12), 1182-1190. https://doi.org/10.1016/0006-3223(91)90154-e
Chugunov, V. V., Safonov, D. N., & Gorodokin, A. D. (2013). Kliniko-statisticheskii i istoriograficheskii analiz predstavlenii ob epidemiologii rasstroistv katatonicheskogo spektra [Clinical and statistical historiographical analysis of epidemiology of catatonic spectum disorders]. Tavricheskii zhurnal psikhiatrii, 17(1), 69-76. [in Russian].
Galderisi, S., & Maj, M. (2009). Deficit schizophrenia: an overview of clinical, biological and treatment aspects. European psychiatry : the journal of the Association of European Psychiatrists, 24(8), 493-500. https://doi.org/10.1016/j.eurpsy.2009.03.001
Gupta, S., Andreasen, N. C., Arndt, S., Flaum, M., Schultz, S. K., Hubbard, W. C., & Smith, M. (1995). Neurological soft signs in neuroleptic-naive and neuroleptic-treated schizophrenic patients and in normal comparison subjects. The American journal of psychiatry, 152(2), 191-196. https://doi.org/10.1176/ajp.152.2.191
Khomitskyi, M. Ye. (2018). Psykhopatolohichni proiavy endohennykh psykhoziv u stanach remisii / intermisii yak predyspozytsiinyi factor personolohichnykh transformatsii (komparanyvnyi analiz) [Psychopathological manifestations of endogenous psychoses in remission / intermission state as a predisposal factor to personological transformations (comparative analysis)]. Zaporozhye medical journal, 20(5), 696-700. [in Ukrainian].
Peralta, V., de Jalón, E. G., Campos, M. S., Basterra, V., Sanchez-Torres, A., & Cuesta, M. J. (2011). Risk factors, pre-morbid functioning and episode correlates of neurological soft signs in drug-naive patients with schizophrenia-spectrum disorders. Psychological medicine, 41(6), 1279-1289. https://doi.org/10.1017/S0033291710001856
Safonov, D. N. (2020). Retrospective analysis of antipsychotic prescription models in correlation with symptoms of residual schizophrenia. Part 1. Journal of Education, Health and Sport, 10(8), 534-541. https://doi.org/10.12775/JEHS.2020.10.08.065
Safonov, D. N. (2020) Symptom correlations of organic brain impairment and psychopathology in patients with residual schizophrenia. Journal of Education, Health and Sport, 10(4), 289-296. https://doi.org/10.12775/JEHS.2020.10.04.032
Schooler, N. R. (1994). Deficit symptoms in schizophrenia: negative symptoms versus neuroleptic-induced deficits. Acta psychiatrica Scandinavica. Supplementum, 380, 21-26. https://doi.org/10.1111/j.1600-0447.1994.tb05827.x
Whitty, P. F., Owoeye, O., & Waddington, J. L. (2009). Neurological signs and involuntary movements in schizophrenia: intrinsic to and informative on systems pathobiology. Schizophrenia bulletin, 35(2), 415-424. https://doi.org/10.1093/schbul/sbn126
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
