Difficulties in diagnosing antibiotic-associated diarrhea using a clinical case example

Authors

DOI:

https://doi.org/10.14739/2310-1210.2023.5.283350

Keywords:

diarrhea, pseudomembranous colitis, diagnosis, treatment

Abstract

Aim. To identify challenges in the diagnosis and treatment of a patient with intestinal damage due to long-term use of antibiotics.

Material and methods. The case of antibiotic-associated diarrhea in a 65-year-old patient is described and analyzed.

Results. The patient with a combined pathology of the gastrointestinal tract and cancer of the sigmoid colon developed a complication after a splenectomy – antibiotic-associated diarrhea. The clinical picture of diarrhea was complicated by the development of pseudomembranous colitis, which was masked by a leukemoid reaction and a septic process. The patient with the relapsing disease course developed multiple organ failure that resulted in a lethal outcome.

Conclusions. Diarrhea associated with Clostridia difficile caused the development of pseudomembranous colitis. At the same time, the clinical picture of the disease had a mask of a leukemoid reaction and a septic process.

Author Biographies

V. I. Kryvenko, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Therapy and Cardiology, Educational and Scientific Institute of Postgraduate Education

I. S. Kachan, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

MD, PhD, Associate Professor of the Department of Therapy and Cardiology, Educational and Scientific Institute of Postgraduate Education

O. P. Fedorova, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

MD, PhD, Associate Professor of the Department of Therapy and Cardiology, Educational and Scientific Institute of Postgraduate Education

A. V. Kechejieva, SI “Territorial Medical Association of the Ministry of Internal Affairs of Ukraine in the Zaporizhzhia region”

MD, physician-therapist 

S. P. Pachomova, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

MD, PhD, Associate Professor of the Department of Therapy and Cardiology, Educational and Scientific Institute of Postgraduate Education

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Published

2023-09-28

How to Cite

1.
Kryvenko VI, Kachan IS, Fedorova OP, Kechejieva AV, Pachomova SP. Difficulties in diagnosing antibiotic-associated diarrhea using a clinical case example. Zaporozhye Medical Journal [Internet]. 2023Sep.28 [cited 2024Nov.18];25(5):472-6. Available from: http://zmj.zsmu.edu.ua/article/view/283350