Monocyte chemoattractant protein-1 and matrix metalloproteinase-9 in patients with type 2 cardiorenal syndrome with chronic heart failure and diabetes type 2 depending on the rate of glomerular filtration
DOI:
https://doi.org/10.14739/2310-1210.2014.5.28757Keywords:
Chronic Heart Failure, Diabetes Mellitus, Cardiorenal Syndrome, Matrix Metalloproteinase-9, Chemokine CCL2Abstract
Aim. The purpose of this study was to analyze changes in MCP-1 as a marker of fibrosis and MMP-9 as an indicator of fibrolysis in patients with CRS and with a background of CHF and type 2 diabetes, depending on the level of glomerular filtration rate.
Methods and results. 80 patients with CHF FC II-III with coronary heart disease (CHD) and who were treated in the cardiology department of the Kharkiv City Clinical Hospital № 27 were examined (mean age 65,13±8,66 years). The first group included 46 patients with CHF diagnosed with type 2 diabetes, the second - 34 CHF patients without diabetes. The study excluded patients with acute coronary syndrome and acute myocardial infarction. MCP-1 was determined by ELISA using a reagent kit «HUMAN MCP-1» (eBiocience,Austria). MMP-9 was determined by ELISA using a reagent kit «HUMAN MMP-9» (eBiocience,Austria).
Conclusion. Progression in patients with type 2 CRS on a background of heart failure and type 2 diabetes associated with a proportional increase fibrosis marker MCP-1, indicating its involvement in tubulointerstitial renal disease. High levels of MMP-9 in patients with type 2 CRS on a background of heart failure and type 2 diabetes in the presence of GFR> 60 mL/min were detected. Reduced GFR <60 mL/min. was not accompanied by a further increase in the activity of an antifibrotic factor. MCP-1 hyperactivity resulted in a cascade of reactions of the progression of interstitial sclerosis.
References
Hatamizadeh, P., Fonarow, G. C., Budoff, M. J., Darabian, S., Kovesdy, C. P., & Kalantar-Zadeh, K. (2012) Cardiorenal syndrome: pathophysiology and potential targets for clinical management. Nat Rev Nephrol. doi: 10.1038/nrneph.2012.279.
McMurray, J., Adamopoulos, S., Anker, S. D., Auricchio, A., Bohm, M., Dickstein, K., et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012. The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. European Journal of Heart Failure, 14, 803–869. doi: 10.1093/eurjhf/hfs105.
Kurumova, K. О. (2010) Faktory fibroza, e`ndotelial'noj disfunkcii i gemostaza u bol'nykh saharnym diabetom i khronicheskoj bolezn'yu pochek [Factors fibrosis, endothelial dysfunction and hemostasis in patients with diabetes and chronic kidney disease]. FGU Mezhdunarodnyj e`ndokrinologicheskij zhurnal, 8, 32. [in Ukrainian].
Van der Meer, P., van Veldhuisen, D. J. (2009) Renal dysfunction in chronic heart failure. Heart, 95, 1808–1812. doi: 10.1136/hrt.2008.151258.
Lytvynova, L. A., & Tonkovyd, A. B. (2008) Suchasnyi stan poshyrenosti tsukrovoho diabetu sered naselennia krain Yevropeiskoho rehionu VOOZ [The current state of the prevalence of diabetes among the population of the European Region of WHO]. Skhisnoievropeiskyi zhurnal hromadskoho zdorovia, 3(3), 92–96. [in Ukrainian].
Wettinger, S. B., Doggen, C. J., & Spek, C. A. (2005) High throughput mRNA profiling highlights associations between myocardial infarction and aberrant expression of inflammatory molecules in blood cells. Blood, 105(5), 2000–2006.
Graham, U. M., Magee, G. M., & Hunter, S. J. (2010) Diabetic nephropathy and chronic kidney disease at a busy diabetes clinic: A study of Outpatient Care and suggestions for improved care pathways at a subspecialty specialist diabetic renal clinic Ulster Med Journal., 79(2), 57–61.
Bradley, A. B., Steven, R. C., et al. (2013) Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome. The New England Journal of Medicine, 2293–2304.
Ibragimova, O. Ju., Hafizov, N. H., & Morugova, T. V. (2007) E'ndotelial'naya disfunkciya u bol'nykh sakharnym diabetom 2 tipa i ishemicheskoj bolezn'yu serdca [Endothelial dysfunction in patients with type 2 diabetes and coronary heart disease] Sibirskij medicinskij zhurnal, 72(5), 40–44. [in Russian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)