Comparative evaluation of anticoagulation therapy effect on coagulation and aggregation hemostasis of patients with Q-wave myocardial infarction after thrombolysis
DOI:
https://doi.org/10.14739/2310-1210.2014.5.28769Keywords:
myocardial infarction, protein C, von Willebrand factor, adhesion moleculesAbstract
Aim. In order to study the effect of anticoagulant therapy on the state of coagulation and aggregation hemostasis, intracardiac hemodynamics, incidence of post-infarction aneurysm and thrombus formation in the left ventricular cavity in patients with Q-myocardial infarction after thrombolysis, 98 people were examined.
Methods and results. All participants underwent echocardiography, the study of coagulation and aggregation hemostasis, defined levels of protein C, von Willebrand factor and adhesion molecules sVCAM-1.
Conclusion. Under the influence of the treatment it was revealed reduction in procoagulant activity of blood serum and activation of fibrinolytic processes, reduced activity of autoimmune reactions and improvement in endothelial function, improved left ventricular systolic function and diastolic dysfunction transformation from impaired relaxation into pseudonormal type.
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