Comparative evaluation of anticoagulation therapy effect on coagulation and aggregation hemostasis of patients with Q-wave myocardial infarction after thrombolysis

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DOI:

https://doi.org/10.14739/2310-1210.2014.5.28769

Keywords:

myocardial infarction, protein C, von Willebrand factor, adhesion molecules

Abstract

Aim. In order to study the effect of anticoagulant therapy on the state of coagulation and aggregation hemostasis, intracardiac hemodynamics, incidence of post-infarction aneurysm and thrombus formation in the left ventricular cavity in patients with Q-myocardial infarction after thrombolysis, 98 people were examined.

Methods and results. All participants underwent echocardiography, the study of coagulation and aggregation hemostasis, defined levels of protein C, von Willebrand factor and adhesion molecules sVCAM-1.

Conclusion. Under the influence of the treatment it was revealed reduction in procoagulant activity of blood serum and activation of fibrinolytic processes, reduced activity of autoimmune reactions and improvement in endothelial function, improved left ventricular systolic function and diastolic dysfunction transformation from impaired relaxation into pseudonormal type.

References

Dzyak, G. V., Koval, E. A., Ivanov, A. P., Shevcova, A. I. (2007) Tip degradacii fibronektina kak novyj dopolnitel'nyj faktor riska tromboticheskikh i gemorragicheskikh oslozhnenij ostrogo infarkta miokarda s zubcom Q [Type of fibronectin degradation as new additional risk factor of thrombotic and hemorrhagic complications of acute Q-wave myocardial infarction]. Sertse i sudyny, 1(17), 13–18. [in Ukrainain].

Kovalenko, V. M., & Kornackii, V. M. (Eds) (2013) Rehionalni medyko-sotsialni problemy khvorob systemy krovoobihu. Dynamika ta analiz. [Regional medical and social problems of cardiovascular system diseases. Dynamics and analysis]. Kyiv. [in Ukrainain].

(2013) ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction 2013. A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, 127, e362-e425.

Halvorsen, S., & Huber, K. (2011) The role of fibrinolysis in the era of primary percutaneous coronary intervention. Thromb. Haemost., 105, 390–395.

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How to Cite

1.
Syvolap VD, Kyselov SM. Comparative evaluation of anticoagulation therapy effect on coagulation and aggregation hemostasis of patients with Q-wave myocardial infarction after thrombolysis. Zaporozhye Medical Journal [Internet]. 2014Oct.20 [cited 2024Nov.13];16(5). Available from: http://zmj.zsmu.edu.ua/article/view/28769

Issue

No. 5 (2014): Zaporozhye medical journal

Section

Original research

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