Nootropic effects of bis(citrato)germanates (stannates) with different metals (Mg, Co) in their structure
DOI:
https://doi.org/10.14739/2310-1210.2014.5.28787Keywords:
Metals, Active Escape, Conditioned-reflectory Activity, Memory, Learning, Nootropic AgentsAbstract
Aim. Nootropic effects of bis(citrato)germanates (stannates) with different metals (Mg, Co) have been investigated in this article. With this aim the peculiarities of conditioned reflex formation as well as short- and long-term memory manifestations under the influence of the investigated coordinative compounds have been studied for 256 rats with the help of pathophysiological and pharmacological methods.
Methods and results. It has been shown that stannates influence on the development of active avoidance conditioned reflex as well as on the manifestations of mnestic functions. It has been found that germacit and gercocit induce positive nootropic effects that occur in case of low dose drugs administration and are characterized by relief of conditioned reflex formation and by short- and long-term memory improvement at the same time.
Conclusion. Stanmacit and stancocit also have nootropic effects that dependent on dose and are characterized by nootropic effect during administration in low doses and by amnestic effect at doses starting from 1/40 LD50. This indicates that stannates show nootropic activity.
References
Varbanets, O. I. (2012) Doslidzhennya vzayemodii novoho ksylaratnoho kompleksu hermaniiu (IV) z ionamy kaliiu ta protysudomnykh preparativ v umovax modeli 6-Gts- vyklykanykh sudom u myshei [The influence of new xylarate germanium (IV) complex interaction with potassium and anticonvulsive drugs in conditions of 6-Hz- induced seizures in mice]. Klinichna ta eksperymentalna patolohiia, 9(3), (Part 1), 19–23. [in Ukrainian].
Seifullina, I. I., Nemiatykh, O. D., Lukianchuk, V. D., & Tkachenko, Ye. V. (2003) Farmakolohichni efekty hermaniieorhanichnykh spoluk [Pharmacological effects of germanium-containing compounds]. Odeskyi medychnyi zhurnal, (6), 110–114. [in Ukrainian].
Marcinko, E. E., Minacheva, L. H., Pesaroglo, A. G., Sejfullina, I. I., Churakov, A. V., & Sergienko, V. S. (2011). Bis(citrato)germanaty dvukhvalentnykh 3d-metallov (Fe, Co, Ni, Cu, Zn). Kristallicheskaya i molekulyarnaya struktura [Fe(H2O)6][Ge(НCit)2]4H2O [Bis (citrate) 3d-germanates divalent metals (Fe, Co, Ni, Cu, Zn). The crystal and molecular structure of [Fe (H2O)6] [Ge (NCit)2] 4H2O.]. Zhurnal neorganicheskoj khimii, 56(8), 1247–1253. [in Russian].
Marcinko, E. E., Minacheva, L. H., Chebanenko, E. A., Sejfullina, I. I., Churakov, A. V., & Sergienko, V. S. (2013). Usloviya obrazovaniya geterometallicheskikh kompleksov v sistemakh GeCl4 (SnCl4) – limonnaya kislota – M(CH3COO)2 – H2O. Kristallicheskaya i molekulyarnaya struktura [M(H2O)6][Ge(НCit)2]4H2O (M = Mg, Mn, Co, Cu, Zn) и [M(H2O)6][Sn(НCit)2]4H2O (M= Mg, Co, Ni) [Conditions for the formation of heterometallic complexes in systems GeCl4 (SnCl4) - citric acid - M (CH3COO) 2 - H2O. Crystal and molecular structure of [M(H2O)6][Ge(НCit)2]4H2O (M = Mg, Mn, Co, Cu, Zn) and [M(H2O)6][Sn(НCit)2]4H2O (M= Mg, Co, Ni)]. Zhurnal neorganicheskoj khimii, 58(5), 588–595. [in Russian].
Shandra, A. A., Voloshenkov, D. B., & Hodovan, V. V. (2005) Vplyv novoi spoluky hermaniiu z nykotynamidom na rizni formy sudomnoho syndromu [The inluence of new germanium with nicotinamide compounds on different forms of convulsive syndrome]. Odeskyi medychnyi zhurnal, (2), 22–25. [in Ukrainian].
Buresh, J., Bureshova, O., & Houston D. (1991) Metodiki i ocnovnye e`kcperimenty po izycheniyu mozga i povedeniya [Methods and Basic Experiments in Brain and Behavioral studies]. Moscow: Vysshaya shkola. [in Russian].
Raevskij, K. S., & Georgiev, V. P. (1986) Mediatornye aminokisloty [Mediator aminoacids]. Moscow: Medicina. [in Russian].
Chuklin, R. Ye., Sampieva, K. T., Ivashev, M. N., Oganova, G. M., & Guseynov, A. K. (2008) Narusheniya mozgovogo krovoobrascheniya i ego korrekciya [Cerebral blood supply deteriorations and its correction]. E`kologiya i zdorov'e, 12, 119–140. [in Russian].
Gerasimov, A. N. (2007). Medicinskaya statistika [Medical statistic]. Moscow: MIA. [in Russian].
Matiushkina, M. V. (2014) Vplyv novykh koordynatsiinykh spoluk hermaniiu, olova ta magniiu z lymonnoiu kyslotoiu na hostru heneralizovanu sudomnu aktyvnist [The influence of new coordinative compounds with germanium, stanum and magnium and citric acid on acute generalized convulsive activity]. Abstracts of Papers of the 6th International Congress, (pp. 90–91). Kyiv. [in Ukrainian].
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