Relationship between central hemodynamic parameters and body composition and the functional state of neuro-autonomic regulation in young men

Authors

DOI:

https://doi.org/10.14739/2310-1210.2024.4.302749

Keywords:

heart rate variability, index of regulation system activity, autonomic nervous system, hemodynamics, obesity, body composition

Abstract

The aim of the study is to examine the relationship between central hemodynamic parameters and body composition by considering baseline functional state of neuro-autonomic regulation according to the index of regulatory system activity (IRSA) in young men.

Material and methods. A total of 44 male participants were divided into three groups based on the IRSA level. The first group included 26 men with an optimal IRSA level. The second and third groups, each of 9 men, with moderate and high IRSA levels, respectively. The functional state of cardiovascular system was assessed using a device “REOKOM” (Kharkiv). The measurement of body composition was performed by weight-scale “TANITA BC-601” (Japan). The functional state of autonomic nervous system was assessed using a device “CARDIOLAB” (Kharkiv).

Results. Our results have demonstrated higher hemodynamic parameters in men with moderate and high level of IRSA. Men with elevated level of sympathetic activity had the highest indices of the pumping function of the heart, and those with the balance between parasympathetic and sympathetic branches had the lowest indices of the pumping heart function. As for the indicators of total peripheral resistance and specific peripheral resistance, another trend was seen, namely, individuals with a balanced state of autonomic nervous regulation had the highest parameters, and those with a predominance of sympathetic tone had the lowest ones. Close correlations have been found between increased levels of regulatory mechanism tension and cardiohemodynamic parameters.

An indicator analysis of the body component composition has revealed a significant increase in body mass index, total and visceral fat content in the examined groups with moderate and severe regulatory system tension. In addition, correlations have been found between IRSA and constituting components of body composition.

Conclusions. The group assignment of the examined individuals according to IRSA has shown that a high tension of the regulatory mechanisms increased the load on the cardiovascular system, as indicated by higher indicators of central hemodynamics. In individuals with an optimal level of regulatory system functioning, the cardiovascular system activity is optimal and less energy consuming.

Author Biographies

O. P. Krichfalushii, State University “Uzhhorod National University”, Ukraine

MD, PhD, Associate Professor of the Department of Physiology and Pathophysiology, Medical Faculty No. 2

M. I. Nemesh, State University “Uzhhorod National University”, Ukraine

MD, PhD, Associate Professor of the Department of Physiology and Pathophysiology, Medical Faculty No. 2

Ya. I. Slyvka, State University “Uzhhorod National University”, Ukraine

MD, PhD, Associate Professor of the Department of Physiology and Pathophysiology, Medical Faculty No. 2

Yu. M. Savka, State University “Uzhhorod National University”, Ukraine

MD, PhD, Associate Professor of the Department of Physiology and Pathophysiology, Medical Faculty No. 2

O. S. Palamarchuk, State University “Uzhhorod National University”, Ukraine

MD, PhD, Associate Professor of the Department of Physiology and Pathophysiology, Medical Faculty No. 2

V. P. Feketa, State University “Uzhhorod National University”, Ukraine

PhD, DSc, Professor, Head of the Department of Physiology and Pathophysiology, Medical Faculty No. 2

References

Russo B, Menduni M, Borboni P, Picconi F, Frontoni S. Autonomic Nervous System in Obesity and Insulin-Resistance-The Complex Interplay between Leptin and Central Nervous System. Int J Mol Sci. 2021;22(10):5187. doi: https://doi.org/10.3390/ijms22105187

Valensi P. Autonomic nervous system activity changes in patients with hypertension and overweight: role and therapeutic implications. Cardiovasc Diabetol. 2021;20(1):170. doi: https://doi.org/10.1186/s12933-021-01356-w

Messina G, Valenzano A, Moscatelli F, Salerno M, Lonigro A, Esposito T, et al. Role of Autonomic Nervous System and Orexinergic System on Adipose Tissue. Front Physiol. 2017;8:137. doi: https://doi.org/10.3389/fphys.2017.00137

Pandit R, Beerens S, Adan RA. Role of leptin in energy expenditure: the hypothalamic perspective. Am J Physiol Regul Integr Comp Physiol. 2017;312(6):R938-R947. doi: https://doi.org/10.1152/ajpregu.00045.2016

Hall ME, Cohen JB, Ard JD, Egan BM, Hall JE, Lavie CJ, et al. Weight-Loss Strategies for Prevention and Treatment of Hypertension: A Scientific Statement From the American Heart Association. Hypertension. 2021;78(5):e38-e50. doi: https://doi.org/10.1161/HYP.0000000000000202

Hall ME, Hall JE. Pathogenesis of hypertension. In: Hypertension: A Companion to Braunwald’s Heart Disease. Elsevier; 2018. p. 33-51. doi: https://doi.org/10.1016/B978-0-323-42973-3.00005-6

Hall JE, Granger JP, do Carmo JM, da Silva AA, Dubinion J, George E, et al. Hypertension: physiology and pathophysiology. Compr Physiol. 2012;2(4):2393-442. doi: https://doi.org/10.1002/cphy.c110058

Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME. Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms. Circ Res. 2015;116(6):991-1006. doi: https://doi.org/10.1161/CIRCRESAHA.116.305697

Fidan-Yaylali G, Yaylali YT, Erdogan Ç, Can B, Senol H, Gedik-Topçu B, et al. The Association between Central Adiposity and Autonomic Dysfunction in Obesity. Med Princ Pract. 2016;25(5):442-8. doi: https://doi.org/10.1159/000446915

Smoljo T, Stanić I, Sila S, Kovačić U, Crnošija L, Junaković A, et al. The Relationship between Autonomic Regulation of Cardiovascular Function and Body Composition. J Obes Metab Syndr. 2020;29(3):188-97. doi: https://doi.org/10.7570/jomes20041

Hillebrand S, de Mutsert R, Christen T, Maan AC, Jukema JW, Lamb HJ, et al. Body fat, especially visceral fat, is associated with electrocardiographic measures of sympathetic activation. Obesity (Silver Spring). 2014;22(6):1553-9. doi: https://doi.org/10.1002/oby.20709

Shauri A, Varghese J, Zainab U, Dawoud O, Bagchi S, Diab F. The association between obesity and the functions of the autonomic nervous system in young adults. International Journal of Health Sciences. 2022;6(S4):11353-76. doi: https://doi.org/10.53730/ijhs.v6nS4.11048

Lambert EA, Straznicky NE, Dixon JB, Lambert GW. Should the sympathetic nervous system be a target to improve cardiometabolic risk in obesity? Am J Physiol Heart Circ Physiol. 2015;309(2):H244-58. doi: https://doi.org/10.1152/ajpheart.00096.2015

Cvijetic S, Macan J, Boschiero D, Ilich JZ. Body fat and muscle in relation to heart rate variability in young-to-middle age men: a cross sectional study. Ann Hum Biol. 2023;50(1):108-16. doi: https://doi.org/10.1080/03014460.2023.2180089

Kim HG, Cheon EJ, Bai DS, Lee YH, Koo BH. Stress and Heart Rate Variability: A Meta-Analysis and Review of the Literature. Psychiatry Investig. 2018;15(3):235-45. doi: https://doi.org/10.30773/pi.2017.08.17

Slyvka YI, Feketa VP, Virah MV, Nemesh MI, Kentesh OP. Comprehensive assessment of autonomic dysfunction in patients with asthma using the regulatory systems activity index. Wiad Lek. 2017;70(6 pt 1):1061-6.

Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996;93(5):1043-65.

Leont’eva Z. [The calculation of adaptation potential, the evaluation of adaptation abilities of the body and the health level of students of Lviv National Medical University by Danylo Halytsky]. Proc Shevchenko Sci Soc. Medical sciences. 2017;47:64-70. Ukrainian. Available from: http://nbuv.gov.ua/UJRN/pntsh_lik_2016_47_10

Marushko YV, Hyshchak TV. Pokaznyky variabelnosti sertsevoho rytmu v otsiniuvanni adaptatsiinykh protsesiv [Indicators of heart rate variability in assessment of adaptation processes]. Health of Ukraine. 2015;0(2):45-6. Ukrainian. Available from: https://health-ua.com/article/6818-pokazniki-varabelnost-sertcevogo-ritmu-v-otcnyuvann-adaptatcjnih-protcesv

Ivanchykova SM. [Bioimpedance analysis component of body composition of university students in the process of fitness]. Naukowyi Chasopys Dragomanov Ukrainian State University. 2016;0(1):13-6. Ukrainian. Available from: http://enpuir.npu.edu.ua/handle/123456789/13981

Tkachyshyna NY. [Analysis of variability data of heart rhythm in the workers of locomotive brigads depending on the experience of the work]. Actual problems of transport medicine. 2017;0(3):83-91. Ukrainian. Available from: http://dspace.nbuv.gov.ua/bitstream/handle/123456789/140171/11Tkachishina.pdf?sequence=1

Hryniv OI. [Ways to improve the results of treatment of arterial hypertension stage I-II: substantiation of the possibilities of using magnesium drugs and psychoemotional correction] [dissertation on the Internet]. Ivano-Frankivsk: Ivano-Frankivsk National Medical University; 2020 [cited 2024 Jun 11]. Ukrainian. Available from: https://nrat.ukrintei.ua/en/searchdoc/0420U101870/

Vadzyuk SN, Huk VO, Tabas PS. [Functional capabilities of the cardiovascular system and stress resistance of individuals with different heat sensitivity]. Fiziol Zh. 2023;69(3):25-30. Ukrainian. doi: https://doi.org/10.15407/fz69.03.024

Khyts AR. ISH 2020: onovleni klinichni rekomendatsii, nova klasyfikatsiia arterialnoi hipertenzii ta sproshchena klasyfikatsiia kardiovaskuliarnoho ryzyku [Updated clinical recommendations, new classification of arterial hypertension and simplified classification of cardiovascular risk]. Ukrainian medical journal [Internet]. 2020 Jun 16:1-3. Ukrainian. Available from: www.umj.com.ua/uk/publikatsia-180785-ish-2020-onovleni-klinichni-rekomendatsiyi-nova-klasifikatsiya-arterialnoyi-gipertenziyi-ta-sproshhena-klasifikatsiya-kardiovaskulyarnogo-riziku

Gorbachova VV, Plegutsa OI. [Obesity and cardio-vascular disorders: review]. Family medicine. 2020;0(3):47-51. Ukrainian. Available from: https://family-medicine.com.ua/2412-8708/article/download/211860/211947/477356

Mishchenko LA. Arterialna hipertenziia: komorbidnist i suputni zakhvoriuvannia [Arterial hypertension: comorbidity and associated diseases]. Health of Ukraine. 2021;0(3):43. Ukrainian. Available from: https://health-ua.com/article/66572-arteralna-gpertenzya-komorbdnst-suputnzahvoryuvannya

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Published

2024-07-17

How to Cite

1.
Krichfalushii OP, Nemesh MI, Slyvka YI, Savka YM, Palamarchuk OS, Feketa VP. Relationship between central hemodynamic parameters and body composition and the functional state of neuro-autonomic regulation in young men. Zaporozhye Medical Journal [Internet]. 2024Jul.17 [cited 2024Jul.18];26(4):275-81. Available from: http://zmj.zsmu.edu.ua/article/view/302749

Issue

Vol. 26 No. 4 (2024): Zaporozhye medical journal

Section

Original research

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