INFLUENCE OF OXYETHYLIZED NONYLPHENOLS AND THEIR DERIVATIVES ON CONTENT OF THYROTROPIN, THYROXIN AND MELATONIN IN THE SERUM OF RATS BLOOD

Authors

  • D. I. Marakushin

DOI:

https://doi.org/10.14739/2310-1210.2014.6.35868

Keywords:

Thyrotropin, Thyroxin, Melatonin, Xenobiotics

Abstract

Aim. Research of pathophysiological mechanisms of xenobiotics action is one of priority tasks of modern medicine. With the purpose of determination of the neuroendocrine processes state, content of hormones of the hypophysis, thyroid gland, epiphysis was studied.

Methods and results. It is established, that on 45 day of the influence of compounds in dose 1/10 DL50 causes the decrease of thyroxin and melatonin content on a background the increase of thyrotropin level. That testifies formation of the tense adaptive state with the initial signs of exhaustion of protectively-compensatory mechanisms.

Conclusion. The long-term influence of compounds in dose 1/10 DL50 causes the increase of thyroxin on a background the decrease of thyrotropin and melatonin, that testifies about formation of the organism state, directed on the maintenance of homeostasis parameters. The disturbance of hormonal profile is one of the pathogenetic link of oxyethylized nonylphenols  mechanisms of action, that is very important.

References

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How to Cite

1.
Marakushin DI. INFLUENCE OF OXYETHYLIZED NONYLPHENOLS AND THEIR DERIVATIVES ON CONTENT OF THYROTROPIN, THYROXIN AND MELATONIN IN THE SERUM OF RATS BLOOD. Zaporozhye medical journal [Internet]. 2014Dec.8 [cited 2024Apr.23];16(6). Available from: http://zmj.zsmu.edu.ua/article/view/35868

Issue

No. 6 (2014): Zaporozhye medical journal

Section

Original research

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