SYNTHESIS AND DIURETIC ACTIVITY OF 2-(5-(PHENOXYMETHYL)-4-R1-1,2,4-TRIAZOLE-3-YLTHIO)ACETIC ACIDS AND THEIR SALTS
DOI:
https://doi.org/10.14739/2310-1210.2014.6.35871Keywords:
1, 2, 4-triazole, diuretic, organic synthesisAbstract
It is known that drugs based on the 1,2,4-triazole have a wide spectrum of biological activities. They are effective cardioprotectors, hepatoprotectors, anti-oxidants, which are widely used in cardiology practice. So this class of heterocyclic compounds has all the attributes of relevance.
We have synthesized new 2-(5-(phenoxymethyl)-4-R1-1,2,4-triazol-3-ylthio) acetate acid and its salts. We have used complex physical and chemical methods of analysis to establish the structure of the synthesized compounds. The chemical properties and diuretic activity of synthesized compounds have been studied. The relation between the structure of obtained salts and their biological effect has been set. Compounds with strong diuretic activity have been found among the newly synthesized compounds. This fact testifies to further study and introduction into medical practice as the original drugs.
References
Berkhin Ye. B. Metody izucheniya deystviya novykh khimicheskikh soyedineniy na funktsiyu pochek / Ye. B. Berkhin // Khim.-farmats. zhurn. – 1977. – T. 11, № 5. – S. 3–11.
Denisenko P.P. Problema farmakologicheskoy zashchity organizma pri deystvii ekstremalnykh faktorov// Fiziologiya ekstremalnykh sostoyaniy i individualnaya zashchita cheloveka. M., 1986. - S. 330.
Doklіnіchnі doslіdzhennya lіkarskikh zasobіv: Metodichnі rekomendatsії / Za red. chlen-kor. AMN Ukraїni O.V. Stefanova. – K.: Avіtsena, 2001. – 528 s.
Kazitsyna L.A., Kupletskaya N.B. Primeneniye UF-, IK-, i YaMR-spektroskopii v organicheskoykhimii. - M.: Vyssh. shk., 1971. - 264 s.
Kucheryaviy Yu. M. Kaplaushenko A. G. Sintez, fіziko-khіmіchnі vlastivostі 5-R-4-R1-1H-1,2,4-trіazol-3-tіonіv // Farmakom. – Kharkіv, - 2014. – Vip. I. – S. 82 – 86.
Sintez ta bіologіchna aktivnіst soley ta yesterіv 2-(5-R-4-(2-metoksifenіl)-1,2,4-trіazol-3-іltіo)atsetatnikh kislot / Gotsulya A. S., Knish Є. G., Shevchenko І. M. [ta іn.] // Lekarstva – cheloveku. Sovremennyye problemy sozdaniya, issledovaniya i aprobatsii lekarstvennykh sredstv : materialy nauch.-prakt. konf., 22 ber. 2007 r. – X., 2007. – S. 25–26.
Sintez і gostra toksichnіst soley 2-(5-R-4-R1-1,2,4-trіazol-3-tіo)-2-(karboksimetiltіo)-karbonotіoіl)gіdrazinoatsetatnikh kislot / A. G. Kaplaushenko, V. V. Parchenko, O. І. Panasenko [ta іn.] // Aktualnі pitannya farmats. ta med. nauki ta praktiki : zb. nauk. st. – Zaporіzhzhya, 2008. – Vip. XXІ, t. 2 (klіnіchna meditsina) : materіali Vseukr. nauk.-prakt. konf. z mіzhnar. uchastyu «Suchasnі aspekti meditsini і farmatsії - 2008». – S. 87–92.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
