SYNTHESIS AND DIURETIC ACTIVITY OF 2-(5-(PHENOXYMETHYL)-4-R1-1,2,4-TRIAZOLE-3-YLTHIO)ACETIC ACIDS AND THEIR SALTS

Authors

DOI:

https://doi.org/10.14739/2310-1210.2014.6.35871

Keywords:

1, 2, 4-triazole, diuretic, organic synthesis

Abstract

It is known that drugs based on the 1,2,4-triazole have a wide spectrum of biological activities. They are effective cardioprotectors, hepatoprotectors, anti-oxidants, which are widely used in cardiology practice. So this class of heterocyclic compounds has all the attributes of relevance.

We have synthesized new 2-(5-(phenoxymethyl)-4-R1-1,2,4-triazol-3-ylthio) acetate acid and its salts. We have used complex physical and chemical methods of analysis to establish the structure of the synthesized compounds. The chemical properties and diuretic activity of synthesized compounds have been studied. The relation between the structure of obtained salts and their biological effect has been set. Compounds with strong diuretic activity have been found among the newly synthesized compounds. This fact testifies to further study and introduction into medical practice as the original drugs.

References

Berkhin Ye. B. Metody izucheniya deystviya novykh khimicheskikh soyedineniy na funktsiyu pochek / Ye. B. Berkhin // Khim.-farmats. zhurn. – 1977. – T. 11, № 5. – S. 3–11.

Denisenko P.P. Problema farmakologicheskoy zashchity organizma pri deystvii ekstremalnykh faktorov// Fiziologiya ekstremalnykh sostoyaniy i individualnaya zashchita cheloveka. M., 1986. - S. 330.

Doklіnіchnі doslіdzhennya lіkarskikh zasobіv: Metodichnі rekomendatsії / Za red. chlen-kor. AMN Ukraїni O.V. Stefanova. – K.: Avіtsena, 2001. – 528 s.

Kazitsyna L.A., Kupletskaya N.B. Primeneniye UF-, IK-, i YaMR-spektroskopii v organicheskoykhimii. - M.: Vyssh. shk., 1971. - 264 s.

Kucheryaviy Yu. M. Kaplaushenko A. G. Sintez, fіziko-khіmіchnі vlastivostі 5-R-4-R1-1H-1,2,4-trіazol-3-tіonіv // Farmakom. – Kharkіv, - 2014. – Vip. I. – S. 82 – 86.

Sintez ta bіologіchna aktivnіst soley ta yesterіv 2-(5-R-4-(2-metoksifenіl)-1,2,4-trіazol-3-іltіo)atsetatnikh kislot / Gotsulya A. S., Knish Є. G., Shevchenko І. M. [ta іn.] // Lekarstva – cheloveku. Sovremennyye problemy sozdaniya, issledovaniya i aprobatsii lekarstvennykh sredstv : materialy nauch.-prakt. konf., 22 ber. 2007 r. – X., 2007. – S. 25–26.

Sintez і gostra toksichnіst soley 2-(5-R-4-R1-1,2,4-trіazol-3-tіo)-2-(karboksimetiltіo)-karbonotіoіl)gіdrazinoatsetatnikh kislot / A. G. Kaplaushenko, V. V. Parchenko, O. І. Panasenko [ta іn.] // Aktualnі pitannya farmats. ta med. nauki ta praktiki : zb. nauk. st. – Zaporіzhzhya, 2008. – Vip. XXІ, t. 2 (klіnіchna meditsina) : materіali Vseukr. nauk.-prakt. konf. z mіzhnar. uchastyu «Suchasnі aspekti meditsini і farmatsії - 2008». – S. 87–92.

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How to Cite

1.
Kucheryavyi YN, Kaplaushenko AG, Pruhlo ES. SYNTHESIS AND DIURETIC ACTIVITY OF 2-(5-(PHENOXYMETHYL)-4-R1-1,2,4-TRIAZOLE-3-YLTHIO)ACETIC ACIDS AND THEIR SALTS. Zaporozhye medical journal [Internet]. 2014Dec.8 [cited 2024Mar.29];(6). Available from: http://zmj.zsmu.edu.ua/article/view/35871

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Section

Problems of pharmacy