Monocytes/macrophages karyologic indices in patients with chronic heart failure

Authors

  • S. V. Fedorov
  • L. Ye. Kovalchuk

DOI:

https://doi.org/10.14739/2310-1210.2015.1.38735

Keywords:

Heart Failure, Cytogenetic Analysis, Monocytes, Macrophages

Abstract

Genetic factors impact in chronic heart failure (HF) development is discussed during last decades.

The aim was to evaluate cytogenetic status of patients with ischemic HF with karyologic analyzes of monocytes/macrophages.

Methods and results. 24 patients and 12 practically healthy persons (control group) were included into the study. Internuclear bridges, perinulcear vacuolization, vacuolization and nuclear chromatin condensation were detected more frequent in patients with HF than in control.

Conclusion. This indicates proliferation activation and is initial signs of apoptosis/necrosis in observed cells.

References

Kalyuzhin, V. V., Teplyakov, A. T., Vecherskij, Yu. Yu. (2007). Patogenez khronicheskoj serdechnoj nedostatochnosti: izmenenie dejstvuyuschej paradigmy. [The pathogenesis of chronic heart failure: the change of current paradigm. Bulleten` sibirskoj mediciny, 4, 71–80. [in Russian].

McMurrey, J., Adamopoulus, S., Anker, S., et al. (2012). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012. European Heart Journal, 33, 1787–1847. doi:10.1093/eurheartj/ehs104.

Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., et al. (2013). Heart diseases and stroke statistics – 2013 update: a report from the American Heart Association. Circulation, 127, e6-e245. doi: 10.1161/CIR.0b013e31828124ad.

Ambrosy, A. P., Fonarov, G. C., Butler, J., Chioncel, O., Greene, S. J., Vaduganathan, M., et al. (2014). The global health and economic burden of hospitalizations for heart failure: lessons learned from HHF registries. Am. Coll. Cardiol., 63, 1123-1133. doi: 10.1016/j.jacc.2013.11.053.

Blair, J. E., Huffman, M., Shah, S. J. (2013). Heart failure in North America. Curr. Cardiol. Rev., 9, 128–146. doi: 10.2174/1573403X11309020006.

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., et al. (2007). Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure. Hypertension, 49, 322–327.

Fatkin, D., Seidman, C., & Seidman, J. (2014). Genetics and disease of ventricular muscle. Cold Spring Harb. Perspect. Med., 4, 23–32. doi: 10.1101/cshperspect.a021063.

Sycheva, L. P. (2007). Biologicheskoe znachenie, kriterii opredeleniya i predely var`irovaniya polnogo spektra kariologicheskikh pokazatelej pri ocenke citologicheskogo statusa cheloveka [Biological significance, criteria for determining and limits of variation of the full range of caryological indicators at evaluating of human cytological status. Medicinskaya genetika, 11, 3–11. [in Russian].

Yurchenko, V. V. (2005). Citogeneticheskie narusheniya v epitelii scheki cheloveka pri ekspozicii genotoksikantami [Cytogenetic abnormalities in the epithelium of the human cheek upon exposure genotoxicants]. Toksikologicheskij vestnik, 6, 14–21. [in Russian].

(2002). European Medicines Agency (2002). ICH Harmonised Tripartite Guideline E6: Note for Guidance on Good Clinical Practice (PMP/ICH/135/95). London: European Medicines Agency.

Recalde, H. R. (1984). A simple method of obtaining monocytes in suspension. J. Immunol. Meth., 69, 71–77. doi: 10.1016/0022-1759(84)90278-3.

(1974) Lechenie raka molochnoh zhelezi s uchetom pokazatelya «polovoj khromatin» [The treatment of breast cancer with indicator «sex chromatin». Кyiv [in Ukrainian].

Pan, Z., Yan, C., Peng, R., Zhao, Y., He, Y., & Ding, J. (2012). Control of cell nucleus shapes via micropillar patterns. Biomaterials, 33, 1730–1735. doi: 10.1016/j.biomaterials.2011.11.023.

Kitaeva, L. V. (2010). Citogeneticheskie narusheniya v slizistoj obolochke fundal`nogo otdela zheludka u pacientov s khronicheskim gastritom [Cytogenetic abnormalities in fundic mucosa of the stomach in patients with chronic gastritis] E`kologicheskaya genetika, 1, 36–41. [in Russian].

How to Cite

1.
Fedorov SV, Kovalchuk LY. Monocytes/macrophages karyologic indices in patients with chronic heart failure. Zaporozhye medical journal [Internet]. 2015Feb.9 [cited 2024Mar.29];17(1). Available from: http://zmj.zsmu.edu.ua/article/view/38735

Issue

Section

Original research