Study of the use possibility of the chemical-biological adduct of the 1,1-bis-[5-bromopyrimidine-2’,4’-diono-1’-il]-2-bromo-2’-chloroethylene and bacterial lectin for the treatment of the Pliss’ lymphosarcoma

Authors

  • O. V. Welchinska

DOI:

https://doi.org/10.14739/2310-1210.2015.2.42048

Keywords:

5-Fluorouracil, Antineoplastic Antimetabolites, Lectins, Lymphatic Sarcoma

Abstract

Aim. Study of the pyrimidine metabolism antimetabolites that can be preformed compounds in the link of biosynthetic processes and can brake tumour’s growth is a more successful, perspective finding direction of new antitumor medications. New original chemical-biological adduct was studied as potential antitumor agent.

Methods and results. It was obtained on the base of 1,1-bis-[5-bromopyrimidine-2’,4’-diono-1’-il]-2-bromo-2’-chloroethylene and antitumour bacterial lectin from Bacillus polymyxa. It was found that new chemical-biological adduct of bis-derivative of pyrimidine and bacterial lectin has little toxic preparation (LD50=635 mg/kg) and demonstrates considerable antitumour effect upon to 65.5% on Pliss Limphosarcoma tumour.

Conclusion. It confirms that new chemical-biological adduct is perspective for the future investigation as substance with a little toxicity and high antitumour activity on the Pliss Limphosarcoma.

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How to Cite

1.
Welchinska OV. Study of the use possibility of the chemical-biological adduct of the 1,1-bis-[5-bromopyrimidine-2’,4’-diono-1’-il]-2-bromo-2’-chloroethylene and bacterial lectin for the treatment of the Pliss’ lymphosarcoma. Zaporozhye Medical Journal [Internet]. 2015Apr.27 [cited 2024Oct.16];17(2). Available from: http://zmj.zsmu.edu.ua/article/view/42048

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Section

Original research