Synthesis, physical-chemical properties and the study of anti-hypoxemic activity of 5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-thion alkylderivatives
DOI:
https://doi.org/10.14739/2310-1210.2015.2.42123Keywords:
derivatives, 1, 2, 4-triazole, physical-chemical properties, anti-hypoxemic activityAbstract
Heterocyclic systems, in particular, 1,2,4-triazole derivatives cause great interest in the development of new medicinal substances for the production of highly effective and safe antihypoxants. This fact has created favorable basis for the synthesis of new alkylderivatives 5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-thion, where R is methyl, phenyl.
Aim. In order to identify the most promising active compounds the pharmacological screening of anti-hypoxemic activity of synthesized compounds has been carried out.
Results. Due to the results of the study a number of compounds with anti-hypoxemic activity have been revealed. Some regularities between structure and pharmacological effect have been established.
Conclusion. This demonstrates the prospects of further studies of the obtained compounds.
References
Simakоv, А. А. (2001). Sovremennaya farmakoterapiya ostrogo infarkta miokarda [Modern pharmacotherapy of acute myocardial infarction]. Samarskij medicinskij zhurnal, 4, 58–59. [in Russian].
Zаrubinа, I. V. & Shаbаnоv, P. D. (2004). Molekulyarnaya farmakologiya antigipoksantov [Molecular pharmacology of antihypoxants]. Saint Petersdburg [in Russian].
Sejfulla, R. D. (2001). Sportivnaya farmakologiya: spravochnik [Sports pharmacology: a Handbook]. Мockov: Moskovskaia pravda. [in Russian].
Stratienko, E. N. (1998). Farmakologicheskaya korrekciya fizicheskoj rabotosposobnosti v usloviyakh gipobaricheskoj gipoksii [Pharmacological correction of physical health capacity of hypobaric hypoxia]. Voenno-medicinskij zhurnal, 2, 31–32. [in Russian].
Оkovytyj, S. V., & Smirnov, А. V. (2001). Antigipoksanty [Antihypoxants]. E'kspertnaya i klinicheskaya farmakologiya, 64(3), 76–80. [in Russian].
Bielenichev, І. F., Kovalenko, S. І., & Dunaiev, V. V. (2002). Antyoksydanty: suchasni uiavlennia, perspektuvu stvorennia [Antioxidants: current knowledge and prospects]. Liky, 1–2, 43–47. [in Ukrainian].
Bobyriev, V. N., Pochernyaeva, V. F., & Starodubcev, S. G. (2005). Specifichnost' sistem antioksidantnoj zaschity organov i tkanej osnova differencirovannoj farmakoterapii antioksidantami [The specificity of the antioxidant defense systems of organs and tissues is the basis of differentiated pharmacotherapy of antioxidants]. E'kspertnaya i klinicheskaya farmakologiya, 57(1), 78–86. [in Russian].
Stefanov, А. V. (Ed). (2001) Мetodychni vkazivky po doklinichnomu vyvchenniu likarskykh zasobiv [Methodical instructions in preclinical studying of drugs]. Кyiv. [in Ukrainian].
Voronina, T. А. (2001). Antioksidant mieksidol. Osnovnye nejropsikhotropnye e'ffekty i mekhanizm dejstviya [Antioxidant Mexidol. Basic neuropsychotropic effects and mechanism of action]. Psihofarmakologiya i biologicheskaya narkologiya, 1, 2–12. [in Russian].
Lapach, S. N., Chubenko, А. V., & Babich, P. N. (2001) Statisticheskie metody v mediko-biologicheskikh issledovaniyakh s ispol'zovaniem Excel [Statistical methods in medic-biological researches, using Excel]. Кyiv: Моrion. [in Ukrainian].
Rebrova, О. Yu. (2002) Statisticheskij аnaliz medicinskikh dannykh. Primenenie paketa prikladnykh program STATISTICA [Statistical analysis of medical information. Using packet of the applied programs]. Мoskva: Меdia-sfera. [in Russian].
Ebtehal, S. Al A. (2007). Synthesis and biological testing of new 1-adamantyl derivatives: submitted in Partial Fulfillmentof the Requirements for the Ph. D. Degree in Pharmaceutical Science «Pharmaceutical Chemistry». Er-Riyad.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
