Synthesis, physical-chemical properties and the study of anti-hypoxemic activity of 5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-thion alkylderivatives
DOI:
https://doi.org/10.14739/2310-1210.2015.2.42123Keywords:
derivatives, 1, 2, 4-triazole, physical-chemical properties, anti-hypoxemic activityAbstract
Heterocyclic systems, in particular, 1,2,4-triazole derivatives cause great interest in the development of new medicinal substances for the production of highly effective and safe antihypoxants. This fact has created favorable basis for the synthesis of new alkylderivatives 5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-thion, where R is methyl, phenyl.
Aim. In order to identify the most promising active compounds the pharmacological screening of anti-hypoxemic activity of synthesized compounds has been carried out.
Results. Due to the results of the study a number of compounds with anti-hypoxemic activity have been revealed. Some regularities between structure and pharmacological effect have been established.
Conclusion. This demonstrates the prospects of further studies of the obtained compounds.
References
Simakоv, А. А. (2001). Sovremennaya farmakoterapiya ostrogo infarkta miokarda [Modern pharmacotherapy of acute myocardial infarction]. Samarskij medicinskij zhurnal, 4, 58–59. [in Russian].
Zаrubinа, I. V. & Shаbаnоv, P. D. (2004). Molekulyarnaya farmakologiya antigipoksantov [Molecular pharmacology of antihypoxants]. Saint Petersdburg [in Russian].
Sejfulla, R. D. (2001). Sportivnaya farmakologiya: spravochnik [Sports pharmacology: a Handbook]. Мockov: Moskovskaia pravda. [in Russian].
Stratienko, E. N. (1998). Farmakologicheskaya korrekciya fizicheskoj rabotosposobnosti v usloviyakh gipobaricheskoj gipoksii [Pharmacological correction of physical health capacity of hypobaric hypoxia]. Voenno-medicinskij zhurnal, 2, 31–32. [in Russian].
Оkovytyj, S. V., & Smirnov, А. V. (2001). Antigipoksanty [Antihypoxants]. E'kspertnaya i klinicheskaya farmakologiya, 64(3), 76–80. [in Russian].
Bielenichev, І. F., Kovalenko, S. І., & Dunaiev, V. V. (2002). Antyoksydanty: suchasni uiavlennia, perspektuvu stvorennia [Antioxidants: current knowledge and prospects]. Liky, 1–2, 43–47. [in Ukrainian].
Bobyriev, V. N., Pochernyaeva, V. F., & Starodubcev, S. G. (2005). Specifichnost' sistem antioksidantnoj zaschity organov i tkanej osnova differencirovannoj farmakoterapii antioksidantami [The specificity of the antioxidant defense systems of organs and tissues is the basis of differentiated pharmacotherapy of antioxidants]. E'kspertnaya i klinicheskaya farmakologiya, 57(1), 78–86. [in Russian].
Stefanov, А. V. (Ed). (2001) Мetodychni vkazivky po doklinichnomu vyvchenniu likarskykh zasobiv [Methodical instructions in preclinical studying of drugs]. Кyiv. [in Ukrainian].
Voronina, T. А. (2001). Antioksidant mieksidol. Osnovnye nejropsikhotropnye e'ffekty i mekhanizm dejstviya [Antioxidant Mexidol. Basic neuropsychotropic effects and mechanism of action]. Psihofarmakologiya i biologicheskaya narkologiya, 1, 2–12. [in Russian].
Lapach, S. N., Chubenko, А. V., & Babich, P. N. (2001) Statisticheskie metody v mediko-biologicheskikh issledovaniyakh s ispol'zovaniem Excel [Statistical methods in medic-biological researches, using Excel]. Кyiv: Моrion. [in Ukrainian].
Rebrova, О. Yu. (2002) Statisticheskij аnaliz medicinskikh dannykh. Primenenie paketa prikladnykh program STATISTICA [Statistical analysis of medical information. Using packet of the applied programs]. Мoskva: Меdia-sfera. [in Russian].
Ebtehal, S. Al A. (2007). Synthesis and biological testing of new 1-adamantyl derivatives: submitted in Partial Fulfillmentof the Requirements for the Ph. D. Degree in Pharmaceutical Science «Pharmaceutical Chemistry». Er-Riyad.
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