Synthesis and antimicrobial activity of 3,5-R-4-(3-(5-nitrofuran-2-yl)-allylidenamino)-1-R1-4H-1,2,4-triazole halides derivatives

Authors

DOI:

https://doi.org/10.14739/2310-1210.2015.2.42124

Keywords:

triazoles, anti-infective agents, analysis

Abstract

Aim. A number of new 3,5-R-4-(3-(5-nitrofuran-2-yl)allylidenami-no)-1-R1-4H-1,2,4-triazole halides have been synthesized, the structure of synthesized compounds has been proved by modern physical-chemical methods.

Methods and results. Experimental substantiation of the antimicrobial activity of newly synthesized derivatives of 3,5-R-4-(3-(5-nitrofuran-2-yl)allylidenamino)-1-R1-4H-1,2,4-triazole halides using disco-diffusion method on Mueller Hinton medium has been performed.

Conclusion. Analysis of the results of microbiological research allowed to determine the substituent’s influence on the antimicrobial activity of 3,5-R-4-(3-(5-nitrofurans-2-yl)allylidenamino)-1-R1-4H-1,2,4-triazolo halides derivatives. The results indicate the prospects for further study.

References

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How to Cite

1.
Brytanova TS, Gotsulya AS, Panasenko OI, Knysh YG, Fedyunina NS. Synthesis and antimicrobial activity of 3,5-R-4-(3-(5-nitrofuran-2-yl)-allylidenamino)-1-R1-4H-1,2,4-triazole halides derivatives. Zaporozhye Medical Journal [Internet]. 2015Apr.27 [cited 2024Nov.22];17(2). Available from: http://zmj.zsmu.edu.ua/article/view/42124

Issue

No. 2 (2015): Zaporozhye medical journal

Section

Problems of pharmacy

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