Influence of renin-angiotensin-aldosterone system block on the systemic inflammation activity and left ventricle remodeling in patients with Q-myocardial infarction after thrombolysis
DOI:
https://doi.org/10.14739/2310-1210.2015.3.44420Keywords:
Myocardial Infarction, Interleukin-6, Interleukin-1-betaAbstract
Aim. Inflammatory cytokines play a role in adaptive postinfarction remodeling of the heart. In order to study the influence of treatment on the condition of systemic inflammatory markers, the incidence of post-infarction aneurysm and thrombus formation in the left ventricle of patients with Q-wave myocardial infarction after thrombolytic therapy serum levels of interleukin-6, interleukin-1-beta, von-Willebrand factor, fibrinogen were studied in 92 patients with immunoassay analysis.
Results and discussion. Remodeling, systolic and diastolic function of the heart were evaluated with echocardiography. Under the influence of the treatment reduction of systemic inflammatory markers activity was showed, which accompanied by improvement of left ventricular systolic function and low frequency of left ventricle aneurysm and thrombus formation.
References
Amosova, E. N., Zaporozhec, O. B., Kazakov, V. E., et al. (1999) Vliyanie ingibitora angiotenzinprevrashchayushchego fermenta e`nalaprila i blokatora receptorov angiotenzina lasartana na rannee remodelirovanie levogo zheludochka u bolnykh s ostrym infarktom miokarda i ego klinicheskoe techenie [Influence of angiotensin-converting enzyme inhibitor enalapril and angiotensin receptor blocker losartan on the early remodelling of the left ventricle in patients with myocardial infarction and its clinical course]. Ukrainskyi medychnyi chasopys, 4(12), 91–96. [in Ukrainian].
Eremina, Yu. N., Leonova, M. V., & Halitskii, A. A. (2014) Antagonisty receptorov k angiotenzinu II: obzor e`ffektivnosti i bezopasnosti [Angiotensin II receptors antagonists: overview of efficiency and safety]. Consilium Medicum Ukraina, 2, 6–11. [in Russian].
(2011). Informatsiinyi biuleten VOOZ [Information bulletin of IHO], 317. [in Ukrainian].
Syvolap, V. D., & Baranov, K. A. (2011) Dinamika aktivnosti markerov nekroza miokarda i citokinov u bol`nykh ostrym koronarnym sindromom s podyomom segmenta ST na el`ektrokardiogramme posle tromboliticheskoj terapii [Dynamics of activity of myocardial necrosis markers and cytokines in patients with acute coronary syndrome with ST segment elevation after thrombolytic therapy]. Zaporozhskij medicinskij zhurnal, 6, 58–60. [in Ukrainian].
Kovalenko, V. M. & Kornatskyi V.M. (Eds.) (2014) Khvoroby systemy krovoobihu yak medyko-sotsialna i suspilno-politychna problema. Analityko-statystychnyi posibnyk [Cardiovascular system diseases as medicine-social and socio-political problem. Analytic-statistical textbook]. Kyiv [in Ukrainian].
Deten, A., Volz, H. C., Briest, W., Zimmer, H. G. (2002) Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rets. Cardiovasc Res., 55, 329–340.
Gullestad, L., Aukrust, P., Ueland, T., Espevik, T., Yee, G., Vagelos, R., et al. (1999) Effect of high-versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure. J. Amer. Coll. Cardiology, 34, 2061–2067. doi:10.1016/S0735-1097(99)00495-7.
Kanda, T., & Takahashi, T. (2004) Interleukin 6 and cardiovascular diseases. Jpn Heart J., 45, 183–193.
Verma, S., Fedac, P. V., Weisel, R. D., Butany, J., Rao, V., Maitland, A, et al. (2002) Fundamentals of reperfusion injury for the clinical cardiologist. Circulation, 105, 2332–2336. doi: 10.1161/01.CIR.0000016602.96363.36.
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