Serum cystatin C as a marker of glomerular kidney damage in patients with chronic glomerulonephritis with saved renal function

Authors

  • O. V. Kraydashenko
  • M. A. Dolinna

DOI:

https://doi.org/10.14739/2310-1210.2015.3.44455

Keywords:

Glomerulonephritis, Glomerular, Cystatin C

Abstract

Improving of glomerular damage diagnostics in chronic glomerulonephritis (CGN) is an actual theme.

Aim. To analyze indicators of glomerular kidney damage in CGN patients.

Methods and results. We examined 81 patients with CGN and saved renal function to analyze indicators of glomerular kidney damage according to vivo morphological kidney study in CGN patients with and without arterial hypertension (AH) and relationship between serum cystatin C (CysC) and histological parameters.

Conclusion. Patients with hypertension had more expressed indicators of glomerular damage than patients without hypertension. We demonstrated that serum cysC is a marker of glomerular kidney damage in patients with CGN. 

References

Kolesnyk, M. O., Saidakova, N. O., Kozliuk, N. I., Vladziievska, H. S., & Kulyzkii, M. V. (2011). Medyko-profilaktychna dopomoha khvorym nefrolohichnoho profiliu v Ukraini [Medical and preventive care to patients of renal profile in Ukraine]. Ukrainskii zhurnal nefrolohii і dializu, 4 (32), 3–11. [in Ukrainian].

Fasset, R. G., Venuthurupalli, К. S., Glenda, C. G., Coombes, J. S., Cooper, M. A., & Hoy, W. E. (2011). Biomarkers in chronic kidney disease: a review. Kidney Int., 80, 806–821. doi: 10.1038/ki.2011.198.

Proletov, Ya. Yu., Saganova, E. S., Galkina, O. V., Zubina, I. M., Bogdanova, E. O., Sipovskii, V. G., & Smirnov, A. V. (2013). Rol' nekotoryh biomarkerov v ocenke kharaktera khronicheskogo povrezhdenija pochek u pacientov s pervichnymi glomerulopatiyami [The role of several biomarkers in estimation of kidney injury in patients with primary glomerulopathies]. Nefrologiya, 17(1), 60–69. [in Russian].

Hojs, R., Bevc, S., Ekart, R., Gorenjak, M., & Puklavec, L. (2008). Serum cystatin C-based equation compared to serum creatinine-based equations for estimation of glomerular filtration rate in patients with chronic kidney disease. Clin. Nephrol., 70(1), 7–10.

Coppo, R., & Cattran, D. (2010). The new oxford clinic-pathological classification of IgA nephropathy. Sec. Biol. Med. Sci., XXXI (1), 241–248.

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How to Cite

1.
Kraydashenko OV, Dolinna MA. Serum cystatin C as a marker of glomerular kidney damage in patients with chronic glomerulonephritis with saved renal function. Zaporozhye Medical Journal [Internet]. 2015Jun.15 [cited 2024Nov.22];17(3). Available from: http://zmj.zsmu.edu.ua/article/view/44455

Issue

No. 3 (2015): Zaporozhye medical journal

Section

Original research

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