Glomerular Function in Term Neonates
DOI:
https://doi.org/10.14739/2310-1210.2015.3.44457Keywords:
Glomerular Filtration, Barrier, Cystatin C, Creatinine, Newborn Infant, PathologyAbstract
Aim. With the aim to detect the condition of glomerular function in term neonates 53 newborns (infants) with clinical signs of pathological course of early neonatal period of severe and moderate degree, and 34 conditionally healthy babies were examined.
Methods and results. The results of the studies were indicative of the fact that in case of combined somatic and neurologic pathology term neonates develop clinical-paraclinical signs of renal dysfunction including disorders of glomerular filtration. Conclusion. Reliable changes of serum creatinine and cystatine C levels as well as glomerular filtration rate calculated by the given markers are evidence of it. At the same time, certain literary data give evidence of higher information value of cystatine C as a marker of glomerular filtration in newborns as compared to the «gold» standard.
References
Boer, D. P., de Rijke, Y. B., Hop, W. C., Cransberg, K., & Dorresteijn, E. M. (2010) Reference values for serum creatinine in children younger than 1 year of age. Pediatr Nephrol, 25, 2107–13. doi: 10.1007/s00467-010-1533-y.
Novo A.C., Sadeck Ldos, S., Okay, T. S., & Leone, C. R. (2011) Longitudinal study of Cystatin C in healthy term newborns. Clinics, 66, 217–20. doi: 10.1590/S1807-59322011000200006.
Mortazavi, F., Hosseinpour Sakha, S., & Nejati, N. (2009) Acute Kidney Failure in Neonatal Period. Iranian Journal of Kidney Diseases, l.3(3), 136–140.
Manal Abd El-Salam, Manal Mohamed Zaher, Ragaa Abd El-Salam Mohamed, Layla Yossef Al Shall, Rayyh A. M. Saleh, & Amal A. Hegazy (2014) Comparison of Some Urinary Biomarkers of Acute Kidney Injury in Term New Born with and without Asphyxia. Clinical Medicine and Diagnostics, 4(2), 23–28. doi:10.5923/j.cmd.20140402.02.
Richardson, D. K., Gray, J. E., McCormick, M. C., Workman, K., & Goldmann, D. A. (1993) Score for Neonatal Acute Physiology: a physiologic severity index for neonatal intensive care. Pediatrics, 91(3), 617–623.
Schwartz, G. J., & Furth, S. L. (2007) Glomerular filtration rate measurement and estimation in chronic kidney disease. Pediatr. Nephrol., 22, 1839–1848.
Grubb, А., Nyman, U., Björk, J, Lindström, V., Rippe, B., Sterner, G., & Christensson, A. (2005) Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children. Clin. Chem., 51(8), 1420–1431.
Girish, Gopal (2014) Acute Kidney Injury (AKI) in perinatal asphyxia. Indian J. Pharm. Biol. Res., 2(2), 60–65.
Sweetman, D. U., & Molloy, E. J. (2013) Biomarkers of acute kidney injury in neonatal encephalopathy. Eur. J. Pediatr., 172, 305–16. doi: 10.1007/s00431-012-1890-6.
Hoseini, R., Otukesh, H., Rahimzadeh, N., & Hoseini, S. (2012) Glomerular Function in Neonates. Iranian Journal of Kidney Diseases, 6(3), 166–172.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
