Synthesis and physical-chemical research of 7-((3-thio-4-r-4h-1,2,4-triazole-5-yl)methyl)theophylline carbonyl derivatives

Authors

  • A. S. Gotsulia
  • P. S. Knyazevich
  • O. I. Panasenko
  • Ye. G. Knysh

DOI:

https://doi.org/10.14739/2310-1210.2015.3.44510

Keywords:

1, 2, 4-triazoles, Theophylline, Synthesis, IR Spectrometry, 1H NMR Spectrometry

Abstract

Aim. To analyze the carbonyl derivatives of 7-((3-thio-4-R-4H-1,2,4-triazole-5-yl)methyl)theophylline their mother substance was synthesized and its interaction with α-haloketones series was carried out.

Methods and results. The physical-chemical properties of the obtained compounds have been studied and their structures have been confirmed by elemental analysis, infrared spectrometry, 1H NMR spectrometry, UV spectrophotometry and gas chromatography mass spectrometry. Preliminary computer study of acute toxicity and biological activity has been also carried out. It has been determined that the obtained compounds may exhibit diuretic and analeptic activity and 1,2,4-triazole fragment can theoretically increase it.

Conclusion. Preliminary prediction of acute toxicity has showed that the compounds are low-toxic. 

 

References

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How to Cite

1.
Gotsulia AS, Knyazevich PS, Panasenko OI, Knysh YG. Synthesis and physical-chemical research of 7-((3-thio-4-r-4h-1,2,4-triazole-5-yl)methyl)theophylline carbonyl derivatives. Zaporozhye Medical Journal [Internet]. 2015Jun.15 [cited 2024Jul.20];17(3). Available from: http://zmj.zsmu.edu.ua/article/view/44510

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Section

Problems of pharmacy