Influence of diuretics with antialdosterone effect on the condition of extracellular matrix and early postinfarction remodeling of the left ventricle in patients with Q-wave myocardial infarction

Authors

  • S. M. Kyselov

DOI:

https://doi.org/10.14739/2310-1210.2015.4.50259

Keywords:

Collagen, Matrix Metalloproteinase-9, Tissue Inhibitor Of Metalloproteinase-1

Abstract

Objective. Aldosterone receptor blockade regulate activity of matrix metalloproteinase system, increase survival in postinfarction period.

Methods and results. In order to study the influence of aldosterone receptor blockade on the serum level of collagen of I and III types, condition of MMP/TIMP system, early postinfarction remodeling of the left ventricle after Q-wave myocardial infarction was studied in 89 patients. The next methods were used: immunoassay analysis of the serum levels of matrix metalloproteinase and its inhibitor, echocardiography. Also systolic and diastolic heart functions were assessed.

Conclusion. Under the influence of the treatment it was showed that the intensity of the degradation of connective tissue matrix of the myocardium reduced, and was accompanied by improvement of the left ventricular systolic and diastolic function.

References

Bagrij, A. E′., Lukashenko, L. V., & Yakovenko, V. G. (2007) Selektivnyj antakhonist al′dosterona Inspra (Eplerenon) v lechenii bolnykh, perenesshikh infarkt miokarda [Selective aldosterone antagonist Inspra (E′plerenone) in treatment of patients after myocardial infarction]. Medicina neotlozhnykh sostoyanij, 1(8), 63–68. [in Ukrainian].

Hryn, V. K. Bassov, O. I. Vatutin, M. T., & Vorobiov, A. S. (2012) Rol systemy matryksnykh metaloproteinaz ta yikh tkanynnykh inhibitoriv u formuvanni postinfarktnoho remodeliuvannia sertsia (analitychnyi ohliad literatury) [The role of matrix metalloprotinase system and their tissue inhibitors in formation of cardiac postinfarction remodelling (analytic literature rewiev)]. Bukovynskyi medychnyi visnyk, 16, 2(62), 152–156. [in Ukrainian].

Rogova, L. N., Shesternina, N. V., Zamechnik, T. V., & Fastova, I. A. (2011) Matriksnye metalloproteinazy, ikh rol' v fiziologicheskikh i patologicheskikh processakh [Matrix metalloproteinases, their role in physiological and pathological processes (review)]. Vestnik novykh medicinskikh tekhnologij, 18(2), 86–89. [in Russian].

Ushakov, A. V., & Gagarina, A. V. (2013) Regulyaciya izmenenij nesokratitel′nykh e′lementov serdechnoj myshcy pri razvitii infarkta miokarda [Regulation of changes of noncontractile elements of heart muscle in development of myocardial infarction]. Serce i sudyny, 3, 118–124. [inUkrainian].

Kovalenko, V. M. & Kornatskyi, V. M. (Eds) (2014) Khvoroby systemy krovoobihu yak medyko-sotsialna i suspilno-politychna problema: Analityko-statystychnyi posibnyk [Cardiovascular system diseases as medicine-social and socio-political problem. Analytic-statistical textbook]. Kyiv [In Ukrainian].

Hsu, C. P., Huang, C. Y., Wang, J. S., Sun, P. C., & Shih, C. C. (2008) Extracellular matrix remodeling attenuated after experimental postinfarct left ventricular aneurysm repair. Ann. Thorac. Surg., 86(4), 1243–1249. doi: 10.1016/j.athoracsur.2008.06.043.

Jugdutt, B. (2003) Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough? Circulation, 108(11), 1395–1403. doi: 10.1161/01.CIR.0000085658.98621.49.

Landmesser, U., Wollert, K., & Drexler, H. (2009) Potential novel pharmacological therapies for myocardial remodeling. Cardiovasc. Res., 81(3), 519–527. doi: 10.1093/cvr/cvn317. Epub 2008 Nov 19.

Matsumura, S., Iwanaga, S., Mochizuki, S., Okamoto, H., Ogawa, S., & Okada, Y. (2005) Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice. Clin. Invest., 115(3), 599–609. doi: 10.1172/JCI200522304.

Patten, R. (2007) Cellular, molecular and structural changes during cardiac remodeling. Hosenpud, J., Greenberg, B. Congestive heart failure. (pp.128–146). Philadelphia, Lippincott: Williams & Wilkins.

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How to Cite

1.
Kyselov SM. Influence of diuretics with antialdosterone effect on the condition of extracellular matrix and early postinfarction remodeling of the left ventricle in patients with Q-wave myocardial infarction. Zaporozhye Medical Journal [Internet]. 2015Sep.16 [cited 2024Nov.5];17(4). Available from: http://zmj.zsmu.edu.ua/article/view/50259

Issue

No. 4 (2015): Zaporozhye medical journal

Section

Original research

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