Influence of the copper nanoparticle-ceftriaxone conjugate on hemodynamic indices in rabbits in an acute experiment
DOI:
https://doi.org/10.14739/2310-1210.2015.4.50300Keywords:
Metal Nanoparticles, Copper, Ceftriaxone, Hemodynamics, SafetyAbstract
An implementation of series of preclinical studies of the copper nanoparticle-ceftriaxone conjugate as a new medication with a broad spectrum of antimicrobial action for treatment of infections, particularly caused by resistant strains, is of great importance nowadays.
The aim of current research was to determinate effect of studied substance on cardiovascular function in animals when administered intravenously in an acute experiment.
Methods and results. The study was carried out on 8 Chinchilla rabbits with monitoring of systemic and cardiac hemodynamic indices with ‘Hewlett Packard’ Hp Viridia Component Monitoring System. It was shown that the copper nanoparticle-ceftriaxone conjugate at doses of 10–200 mg/kg did not have a negative impact on the heart rate, maximum left ventricular pressure, systolic, diastolic blood pressure, the pulse pressure, and the mean arterial pressure.
Conclusion. These findings attest to the fact that the copper nanoparticle-ceftriaxone conjugate may be considered a biosafe substance in the terms of an influence on systemic and cardiac hemodynamic indices when administered intravenously to rabbits in an acute experiment.
References
Llor, C., & Bjerrum, L. (2014). Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Therapeutic Advances in Drug Safety, 5(6), 229–241. doi: 10.1177/2042098614554919.
Chekman, І. S., Ulberg, Z. R., Malanchuk, V. O., Gorchakova, N. O., Zupanets, І. A., Shatorna, V. F., et al. (2012). Nanonauka, nanobіologіia, nanofarmatsіia [Nanoscience, nanobiology, nanopharmacy]. Kyiv: Polіgraf Plyus. [inUkrainian].
Ingle, A. P., Duran, N., & Rai, M. (2014). Bioactivity, mechanism of action, and cytotoxicity of copper-based nanoparticles: A review. Applied Microbiology and Biotechnology, 98(3), 1001–1009. doi: 10.1007/s00253-013-5422-8.
Mehta, K. C., Dargad, R. R., Borade, D. M., & Swami, O. C. (2014). Burden of antibiotic resistance in common infectious diseases: Role of antibiotic combination therapy. Journal of Clinical and Diagnostic Research, 8(6), ME05–ME08. doi: 10.7860/JCDR/2014/8778.4489.
Ali, A. E. (2011). Synthesis, spectral, thermal and antimicrobial studies of some new tri metallic biologically active ceftriaxone complexes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 78(1), 224–230. doi: 10.1016/j.saa.2010.09.025.
Allahverdiyev, A. M., Kon, K. V., Abamor, E. S., Bagirova, M., & Rafailovich, M. (2011). Coping with antibiotic resistance: combining nanoparticles with antibiotics and other antimicrobial agents. Expert Review of Anti-infective Therapy, 9(11), 1035–1052. doi: 10.1586/eri.11.121.
Privalova, L. I., Katsnelson, B. A., Loginova, N. V., Gurvich, V. B., Shur, V. Y., Valamina, I. E., et al. (2014). Subchronic toxicity of copper oxide nanoparticles and its attenuation with the help of a combination of bioprotectors. International Journal of Molecular Sciences, 15(7), 12379–12406. doi: 10.3390/ijms150712379.
Wang, Y. C., Hu, C. W., Liu, M. Y., Jiang, H. C., Huo, R., & Dong, D. L. (2013). Copper induces vasorelaxation and antagonizes noradrenaline-induced vasoconstriction in rat mesenteric artery. Cellular Physiology and Biochemistry, 32(5), 1247–1254. doi: 10.1159/000354523.
Lamb, H. M., Ormrod, D., Scott, L. J., & Figgitt, D. P. (2002). Ceftriaxone: An update of its use in the management of community-acquired and nosocomial infections. Drugs, 62(7), 1041–1089.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
