Endothelial dysfunction of vessels at ANCA-associated systemic vasculitis

Authors

  • L. V. Sedaia
  • O. V. Syniachenko
  • M. V. Iermolaieva
  • T. B. Bevzenko

DOI:

https://doi.org/10.14739/2310-1210.2015.4.50305

Keywords:

Vasculitis, Vascular Endothelium, Antibodies

Abstract

Aim. To evaluate clinical-pathogenetic relationship between systemic vasculitis associated with anti-neutrophil cytoplasmic antibodies and vascular endothelial dysfunction. Materials and methods. In order to clarify relationships between clinical course of systemic vasculitis with the state of the endothelial vascular function the indicators of endothelial function of vessels in blood (the levels of endothelin-1, thromboxane A2, homocysteine, prostacyclins, nitrites, cyclic guanosine monophosphate) were studied with biochemical and immunoenzyme methods in 129 patients (76 - with microscopic polyangiitis, 26 – with Wegener's granulomatous polyangiitis and 27 - with eosinophilic polyangiitis Churg-Strauss). Results. The imbalance of levels of vasoconstrictors and vasodilators was determined. It was manifested by increased concentrations of endothelin-1 and nitrites in the background of the the amount of prostacyclin and homocysteine reduce.

Conclusions. The abnormality of endothelial dysfunction of vessels in systemic vasculitis were involved in the vasculitis pathogenesis.

 

References

Basu, N., McClean, A., Harper, L., Amft, E. N., Dhaun, N., Luqmani, R. A. et al. (2014). Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis. Rheumatology, 53(5), 953–956. doi: 10.1093/rheumatology/ket483.

Tsuchiya, N. (2013). Genetics of ANCA-associated vasculitis in Japan: a role for HLA-DRB1*09:01 haplotype. Clin Exp Nephrol, 17(5), 628–630. doi: 10.1007/s10157-012-0691-6.

Watts, R. A., Mooney, J., Skinner, J., Scott D. G., & Macgregor, A. J. (2012). The contrasting epidemiology of granulomatosis with polyangiitis (Wegener's) and microscopic polyangiitis. Rheumatology, 51(5), 926–931. doi: 10.1093/rheumatology/ker454.

Santana, A. N., Woronik, V., Halpern, A. S., & Barbas C. S. (2011). Treatment of antineutrophil cytoplasmic antibody-associated vasculitis: update. J Bras Pneumol, 37(6), 809–816. http://dx.doi.org/10.1590/S1806-37132011000600016

Mouthon, L., Dunogue, B., & Guillevin L. (2014). Diagnosis and classification of eosinophilic granulomatosis with polyangiitis (formerly named Churg-Strauss syndrome). J Autoimmun, 48–49, 99–103. doi: 10.1016/j.jaut.2014.01.018.

Aydin, Z., Gursu, M., Karadag, S., Uzun, S., Tatli, E., Sumnu A., et al. (2011) Role of plasmapheresis performed in hemodialysis units for the treatment of anti-neutrophilic cytoplasmic antibody-associated systemic vasculitides. Ther Apher Dial, 15(5), 493–498. doi: 10.1111/j.1744-9987.2011.00960.x.

Wilson, A. S., Bacon, P. A., & Young, S. P., & Carruthers, D. M. (2010). Vasculitis integrated clinical assessment database: a data management system to support studies into systemic vasculitis. J Clin Rheumatol, 16(1), 10–14. doi: 10.1097/RHU.0b013e3181c6813f.

Gibelin, A., Maldini, C., & Mahr A. (2011). Epidemiology and etiology of wegener granulomatosis, microscopic polyangiitis, churg-strauss syndrome and goodpasture syndrome: vasculitides with frequent lung involvement. Semin Respir Crit Care Med, 32(3), 264–273. doi: 10.1055/s-0031-1279824.

Khalidi, N. A. (2011). ANCA-associated vasculitides and classification: a conundrum solved? J Rheumatol, 38(6), 971–972. doi: 10.3899/jrheum.110146.

Nachman, P. H., & Henderson, A. G. (2011). Pathogenesis of lung vasculitis. Semin Respir Crit Care Med, 32(3), 245–253. doi: 10.1055/s-0031-1279822.

Nijenhuis, H. L., de Leeuw, K., Smit, A. J., et al. (2011). Enhanced endothelium-dependent microvascular responses in patients with Wegener's granulomatosis. J Rheumatol, 34(9), 1875–1881.

Raza, K., Carruthers, D. M., & Stevens, R. (2012). Infliximab leads to a rapid but transient improvement in endothelial function in patients with primary systemic vasculitis. Ann Rheum Dis, 65(7), 946–948.

De Leeuw, K., Bijzet, J., van der Graaf, A. M., Stegeman, C. A., Smit, A. J., Kallenberg, C. G., & Bijl, M. (2010). Patients with Wegener's granulomatosis: a long-term follow-up study. Clin Exp Rheumatol, 28(1), 18–20.

Downloads

How to Cite

1.
Sedaia LV, Syniachenko OV, Iermolaieva MV, Bevzenko TB. Endothelial dysfunction of vessels at ANCA-associated systemic vasculitis. Zaporozhye medical journal [Internet]. 2015Sep.16 [cited 2024Apr.20];17(4). Available from: http://zmj.zsmu.edu.ua/article/view/50305

Issue

No. 4 (2015): Zaporozhye medical journal

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)